Evidence map›Paper›PMID 26391404›Full record

ArticleNature communications2015

Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer.

Kate Lawrenson, Qiyuan Li, Siddhartha Kar, Ji-Heui Seo, Jonathan Tyrer, Tassja J Spindler, Janet Lee, Yibu Chen, Alison Karst, Ronny Drapkin and 154 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.

  1. Pooled it
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  12. Molecular Management of High-Grade Serous Ovarian Carcinoma.International journal of molecular sciences · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

164 authors at 20 institutions in 16 countries.

Kate LawrensonDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
Qiyuan LiMedical College, Xiamen University, Xiamen 361102, China.
Siddhartha KarDepartment of Oncology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK.
Ji-Heui SeoDepartment of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
Jonathan TyrerDepartment of Oncology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK.
Tassja J SpindlerDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
Janet LeeDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
Yibu ChenBioinformatics Service, Norris Medical Library, University of Southern California, Los Angeles, California 90033, USA.
Alison KarstDepartments of Pathology and Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA.
Ronny DrapkinDepartments of Pathology and Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA.
Katja K H AbenDepartment for Health Evidence, Radboud University Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
Hoda Anton-CulverDepartment of Epidemiology, Director of Genetic Epidemiology Research Institute, School of Medicine, University of California Irvine, Irvine, California 92697, USA.
Natalia AntonenkovaByelorussian Institute for Oncology and Medical Radiology Aleksandrov N.N., 223040 Minsk, Belarus.
Australian Ovarian Cancer Study Group
Helen BakerDepartment of Oncology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK.
Elisa V BanderaCancer Prevention and Control, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA.
Yukie BeanDepartment of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon 97239, USA.
Matthias W BeckmannDepartment of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany.
Andrew BerchuckDepartment of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Maria BisognaGynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Line BjorgeDepartment of Gynecology and Obstetrics, Haukeland University Hospital, N-5058 Bergen, Norway.
Natalia BogdanovaGynaecology Research Unit, Hannover Medical School, 30625 Hannover, Germany.
Louise A BrintonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda Maryland, 20892, USA.
Angela Brooks-WilsonCanada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z 1L3.
Fiona BruinsmaCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia.
Ralf ButzowDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, 00100 Helsinki, Finland.
Ian G CampbellCancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria 3002, Australia.
Karen CartyCancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow G12 0YN, UK.
Jenny Chang-ClaudeGerman Cancer Research Center (DKFZ), Division of Cancer Epidemiology, 69120 Heidelberg, Germany.
Georgia Chenevix-TrenchCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
Anne ChenDepartment of Biostatistics, Moffitt Cancer Center, Tampa, Florida 33612, USA.
Zhihua ChenDepartment of Biostatistics, Moffitt Cancer Center, Tampa, Florida 33612, USA.
Linda S CookDivision of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico 87131, USA.
Daniel W CramerHarvard School of Public Health, Boston, Massachusetts 02215, USA.
Julie M CunninghamDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Cezary CybulskiDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Agnieszka Dansonka-MieszkowskaDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Joe DennisCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Ed DicksDepartment of Oncology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK.
Jennifer A DohertyDepartment of Epidemiology, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire 03756, USA.
Thilo DörkGynaecology Research Unit, Hannover Medical School, 30625 Hannover, Germany.
Andreas du BoisDepartment of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, 45136 Essen, Germany.
Matthias DürstDepartment of Gynecology, Jena University Hospital-Friedrich Schiller University, 07737 Jena, Germany.
Diana EcclesFaculty of Medicine, University of Southampton, Southampton SO16 5YA, UK.
Douglas T EastonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Robert P EdwardsDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.
Ursula EilberGerman Cancer Research Center (DKFZ), Division of Cancer Epidemiology, 69120 Heidelberg, Germany.
Arif B EkiciUniversity Hospital Erlangen, Institute of Human Genetics, Friedrich-Alexander-University Erlangen-Nuremberg, 91054 Erlangen, Germany.
Peter A FaschingDepartment of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany.
Brooke L FridleyBiostatistics and Informatics Shared Resource, University of Kansas Medical Center, Kansas City, Kansas, 66160, USA.
Yu-Tang GaoShanghai Cancer Institute, Shanghai 200030, China.
Aleksandra Gentry-MaharajDepartment of Women's Cancer, Institute for Women's Health, University College London, London W1T 7DN, UK.
Graham G GilesCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia.
Rosalind GlasspoolCancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow G12 0YN, UK.
Ellen L GoodeDepartment of Health Science Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Marc T GoodmanCancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
Jacek GrownwaldDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Patricia HarringtonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Philipp HarterDepartment of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, 45136 Essen, Germany.
Hanis Nazihah HasmadCancer Research Initiatives Foundation, Sime Darby Medical Centre, 47500 Subang Jaya, Malaysia.
Alexander HeinDepartment of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany.
Florian HeitzDepartment of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, 45136 Essen, Germany.
Michelle A T HildebrandtDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Peter HillemannsDepartments of Obstetrics and Gynaecology, Hannover Medical School, 30625 Hannover, Germany.
Estrid HogdallInstitute of Cancer Epidemiology, Danish Cancer Society, DK-2100 Copenhagen, Denmark.
Claus HogdallGyn Clinic, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.
Satoyo HosonoDivision of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-0021, Japan.
Edwin S IversenDepartment of Statistical Science, Duke University, Durham, North Carolina 27708, USA.
Anna JakubowskaDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Paul JamesCancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow G12 0YN, UK.
Allan JensenDepartment of Gynecology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.
Bu-Tian JiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda Maryland, 20892, USA.
Beth Y KarlanWomen's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
Susanne Kruger KjaerDepartment of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark.
Linda E KelemenDepartment of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston, South Carolina 29435, USA.
Melissa KellarDepartment of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon 97239, USA.
Joseph L KelleyDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.
Lambertus A KiemeneyRadboud University Medical Mentre, Radboud Institute for Health Sciences, 6500 HB Nijmegen, The Netherlands.
Camilla KrakstadDepartment of Gynecology and Obstetrics, Haukeland University Hospital, N-5058 Bergen, Norway.
Jolanta KupryjanczykDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Diether LambrechtsVesalius Research Center, VIB, 3000 Leuven, Belgium.
Sandrina LambrechtsDivision of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, B-3000 Leuven, Belgium.
Nhu D LeCancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z 1L3.
Alice W LeeDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
Shashi LeleDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
Arto LeminenDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, 00100 Helsinki, Finland.
Jenny LesterWomen's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
Douglas A LevineGynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Dong LiangCollege of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas 77004, USA.
Jolanta LissowskaDepartment of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Karen LuDepartment of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Jan LubinskiDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Lene LundvallMolecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, 1165 Copenhagen, Denmark.
Leon F A G MassugerDepartment of Gynaecology, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands.
Keitaro MatsuoDepartment of Preventive Medicine, Kyushu University Faculty of Medical Sciences, 819-0395 Fukuoka, Japan.
Valerie McGuireDepartment of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford California 94305, USA.
John R McLaughlinProsserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5.
Heli NevanlinnaDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, 00100 Helsinki, Finland.
Ian McNeishInstitute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research, University of Glasgow, Glasgow G61 1QH, UK.
Usha MenonDepartment of Women's Cancer, Institute for Women's Health, University College London, London W1T 7DN, UK.
Francesmary ModugnoDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.
Kirsten B MoysichDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
Steven A NarodDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10017, USA.
Lotte NedergaardDepartment of Pathology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.
Roberta B NessThe University of Texas School of Public Health, Houston, Texas 77030, USA.
Mat Adenan Noor AzmiDepartment of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, 50603 Kuala Lumpur, Malaysia.
Kunle OdunsiDepartment of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
Sara H OlsonDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10017, USA.
Irene OrlowDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10017, USA.
Sandra OrsulicWomen's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
Rachel Palmieri WeberDepartment of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.
Celeste L PearceDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
Tanja PejovicDepartment of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon 97239, USA.
Liisa M PelttariDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, 00100 Helsinki, Finland.
Jennifer Permuth-WeyDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida 33612, USA.
Catherine M PhelanDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida 33612, USA.
Malcolm C PikeDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
Elizabeth M PooleChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA.
Susan J RamusDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
Harvey A RischDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut 06510, USA.
Barry RosenDepartment of Gynecologic-Oncology, Princess Margaret Hospital, and Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 2J7.
Mary Anne RossingProgram in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Joseph H RothsteinDepartment of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford California 94305, USA.
Anja RudolphGerman Cancer Research Center (DKFZ), Division of Cancer Epidemiology, 69120 Heidelberg, Germany.
Ingo B RunnebaumDepartment of Gynecology, Jena University Hospital-Friedrich Schiller University, 07737 Jena, Germany.
Iwona K RzepeckaDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Helga B SalvesenDepartment of Gynecology and Obstetrics, Haukeland University Hospital, N-5058 Bergen, Norway.
Joellen M SchildkrautCancer Control and Population Sciences, Duke Cancer Institute, Durham, North Carolina 27710, USA.
Ira SchwaabInstitut für Humangenetik Wiesbaden, 65187 Wiesbaden, Germany.
Thomas A SellersDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida 33612, USA.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.
Yurii B ShvetsovCancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, 96813, USA.
Nadeem SiddiquiDepartment of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow G4 0SF, UK.
Weiva SiehDepartment of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford California 94305, USA.
Honglin SongDepartment of Oncology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK.
Melissa C SoutheyDepartment of Pathology, University of Melbourne, Parkville, Victoria 3010, Australia.
Lara SuchestonDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
Ingvild L TangenDepartment of Gynecology and Obstetrics, Haukeland University Hospital, N-5058 Bergen, Norway.
Soo-Hwang TeoCancer Research Initiatives Foundation, Sime Darby Medical Centre, 47500 Subang Jaya, Malaysia.
Kathryn L TerryHarvard School of Public Health, Boston, Massachusetts 02215, USA.
Pamela J ThompsonCancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
Agnieszka TimorekDepartment of Obstetrics, Gynecology and Oncology, IInd Faculty of Medicine, Warsaw Medical University and Brodnowski Hospital, Warsaw, Poland.
Ya-Yu TsaiDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida 33612, USA.
Shelley S TworogerChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA.
Anne M van AltenaDepartment of Gynaecology, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands.
Els Van NieuwenhuysenDivision of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, B-3000 Leuven, Belgium.
Ignace VergoteDivision of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, B-3000 Leuven, Belgium.
Robert A VierkantDepartment of Health Science Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Shan Wang-GohrkeDepartment of Obstetrics and Gynecology, University of Ulm, 89075 Ulm, Germany.
Christine WalshWomen's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
Nicolas WentzensenDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda Maryland, 20892, USA.
Alice S WhittemoreDepartment of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford California 94305, USA.
Kristine G WicklundProgram in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Lynne R WilkensCancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, 96813, USA.
Yin-Ling WooDepartment of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, 50603 Kuala Lumpur, Malaysia.
Xifeng WuDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Anna H WuDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
Hannah YangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda Maryland, 20892, USA.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.
Argyrios ZiogasDepartment of Epidemiology, Director of Genetic Epidemiology Research Institute, School of Medicine, University of California Irvine, Irvine, California 92697, USA.
Alvaro MonteiroCancer Epidemiology Program, Division of Population Sciences, H. Lee Moffitt Cancer Center &Research Institute, Tampa, Florida 33612, USA.
Paul D PharoahDepartment of Oncology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK.
Simon A GaytherDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
Matthew L FreedmanDepartment of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
University of Southern California · USCedars-Sinai Medical Center · USUniversity of Cambridge · GBMoffitt Cancer Center · USRoswell Park Comprehensive Cancer Center · USBrigham and Women's Hospital · USUniversity of Copenhagen · DKFriedrich-Alexander-Universität Erlangen-Nürnberg · DEGerman Cancer Research Center · DEMayo Clinic · USRadboud University Nijmegen · NLThe University of Texas MD Anderson Cancer Center · USUniversity of Pittsburgh · USDana-Farber Cancer Institute · USMemorial Sloan Kettering Cancer Center · USOregon Health & Science University · USUniversity Malaya Medical Centre · MYUniversity of Hawaiʻi at Mānoa · USBC Cancer Agency · CABeatson West of Scotland Cancer Centre · GB

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
Hormone-Related CancersZIACP010126 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI GIERACH, GRETCHEN · 2009 to 2025
$103.5M
TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KENNETH Lynn WRIGHT · 1998 to 2026
$93.5M
University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Xin Chen · 1996 to 2026
$56.2M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
Ovarian cancer GWAS discovery, expansion and replication (N2 - Project #1)U19CA148112 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI SELLERS, THOMAS A · 2010 to 2014
$10.2M
Shanghai Womens Health StudyUM1CA182910 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHENG, WEI · 2014 to 2018
$5.9M
Utilizing genetic and functional strategies to identify causal genes and allelesR01GM107427 · NIGMS · DANA-FARBER CANCER INST · PI FREEDMAN, MATTHEW L, JOUNG, J. KEITH · 2014 to 2017
$2.0M
Identifying Ovarian Cancer Susceptibility Alleles using Genome-Wide Scan DataR01CA141154 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GAYTHER, SIMON ANDREW, PEARCE, CELESTE LEIGH · 2010 to 2012
$2.0M
Functional Analysis of LncRNAs in Epithelial Ovarian CancerK99CA184415 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LAWRENSON, KATE · 2014 to 2014
$97k
Cancer Research UK 10124Cancer Research UK 16561CIHR MSH-87734NCATS NIH HHS UL1 TR000005NCI NIH HHS 1K99CA184415-01NCI NIH HHS K99 CA184415NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA014089NCI NIH HHS P30CA014089NCI NIH HHS P30 CA071789NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA141154NCI NIH HHS U19 CA148112NCI NIH HHS U19-CA148112NCI NIH HHS UM1 CA182910NIGMS NIH HHS R01 GM107427Wellcome TrustWellcome Trust 076113
6 · The paper itself

Abstract

Genome-wide association studies have reported 11 regions conferring risk of high-grade serous epithelial ovarian cancer (HGSOC). Expression quantitative trait locus (eQTL) analyses can identify candidate susceptibility genes at risk loci. Here we evaluate cis-eQTL associations at 47 regions associated with HGSOC risk (P≤10(-5)). For three cis-eQTL associations (P<1.4 × 10(-3), FDR<0.05) at 1p36 (CDC42), 1p34 (CDCA8) and 2q31 (HOXD9), we evaluate the functional role of each candidate by perturbing expression of each gene in HGSOC precursor cells. Overexpression of HOXD9 increases anchorage-independent growth, shortens population-doubling time and reduces contact inhibition. Chromosome conformation capture identifies an interaction between rs2857532 and the HOXD9 promoter, suggesting this SNP is a leading causal variant. Transcriptomic profiling after HOXD9 overexpression reveals enrichment of HGSOC risk variants within HOXD9 target genes (P=6 × 10(-10) for risk variants (P<10(-4)) within 10 kb of a HOXD9 target gene in ovarian cells), suggesting a broader role for this network in genetic susceptibility to HGSOC.

Indexed as

Genetic Association StudiesQuantitative Trait LociCarcinoma, Ovarian EpithelialCell Line, TumorFemaleGene Expression Regulation, NeoplasticGenetic Predisposition to DiseaseHomeodomain ProteinsHumansNeoplasm ProteinsNeoplasms, Glandular and EpithelialNuchal CordOvarian NeoplasmsProtein BindingHomeodomain ProteinsHOXD9 protein, humanNeoplasm Proteins

Identifiers

PMID26391404
PMCPMC4580986
OpenAlexW2196905301

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