ArticleScientific reports2015
Dual E627K and D701N mutations in the PB2 protein of A(H7N9) influenza virus increased its virulence in mammalian models.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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54 citing papers in PubMed, 75 citations in OpenAlex.
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- Genomic analysis of high pathogenicity avian influenza viruses from Antarctica reveals multiple introductions from South America.Nature communications · 2026Article
- Dispersal, adaptation and persistence of H5N1 in the sub-Antarctic and Antarctica.bioRxiv : the preprint server for biology · 2026Article
- Baloxavir outperforms oseltamivir, favipiravir, and amantadine in treating lethal influenza A(H5N1) HA clade 2.3.4.4b infection in mice.Nature communications · 2026Article
- Enhanced genome replication activity of pandemic H1N1 influenza A virus through PA mutations.Journal of virology · 2026Article
- Genetic Characterization and Pathogenicity of a Triple-Reassortant H1N1 Swine Influenza Virus Isolated in Guangdong.Transboundary and emerging diseases · 2026Article
- Early detection and genetic characterization of clade 2.3.4.4b H5N1 and H5N9 highly pathogenic avian influenza viruses at the onset of fall migration in wild birds during october 2025 in South Korea.Frontiers in cellular and infection microbiology · 2026Article
- Rapid surge of reassortant A(H1N1) influenza viruses in Danish swine and their zoonotic potential.Emerging microbes & infections · 2025Article
- Amino acid substitutions associated with adaptation of novel H10N3 and H10N5 avian influenza viruses to mice.Archives of virology · 2025Article
- Converging Transmission Routes of the Highly Pathogenic Avian Influenza H5N1 Clade 2.3.4.4b Virus in Uruguay: Phylogeographic Insights into Its Spread Across South America.Pathogens (Basel, Switzerland) · 2025Article
- Article
- Genetic diversity of H9N2 avian influenza viruses in poultry across China and implications for zoonotic transmission.Nature microbiology · 2025Article
- Synergistic effects of PA (S184N) and PB2 (E627K) mutations on the increased pathogenicity of H3N2 canine influenza virus infections in mice and dogs.Journal of virology · 2025Article
- Are we cultivating the perfect storm for a human avian influenza pandemic?Biological research · 2024Review
- Epidemiological data of an influenza A/H5N1 outbreak in elephant seals in Argentina indicates mammal-to-mammal transmission.Nature communications · 2024Article
- Characterization and Pathogenicity of Novel Reassortment H6N6 Avian Influenza Viruses in Southern China.Transboundary and emerging diseases · 2024Article
- Emergence of HPAI H5N6 Clade 2.3.4.4b in Wild Birds: A Case Study From South Korea, 2023.Transboundary and emerging diseases · 2024Article
- Evolutionary characterization of the establishment of H6 influenza viruses in domestic geese in China: implications for the position of the host in the ecosystem.Virus evolution · 2024Article
- Epidemiology, evolution, and biological characteristics of H6 avian influenza viruses in China.Emerging microbes & infections · 2023Article
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14 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The ongoing avian H7N9 influenza outbreaks in China have caused significant human fatal cases and the virus is becoming established in poultry. Mutations with potential to increase mammalian adaptation have occurred in the polymerase basic protein 2 (PB2) and other viral genes. Here we found that dual 627K and 701N mutations could readily occur during transmission of the virus among ferrets via direct physical contact, and these mutations conferred higher polymerase activity and improved viral replication in mammalian cells, and enhanced virulence in mice. Special attention needs to be paid to patients with such mutations, as these may serve as an indicator of higher virus replication and increased pathogenicity.
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