ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2016
High Serum SHBG Predicts Incident Vertebral Fractures in Elderly Men.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Sex hormone-binding globulin and risk of fracture in older adults: systematic review and meta-analysis of observational studies.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Pooled it
- Identification of Hip BMD Loss and Fracture Risk Markers Through Population-Based Serum Proteomics.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Trial
- Comprehensive insights into bone health, hormonal patterns, and fracture risks among men with drug resistant epilepsy: a crucial evaluation.Archives of endocrinology and metabolism · 2026Article
- Insights into osteoporosis triggered by common antiepileptic drugs via network toxicology, molecular docking and molecular dynamics simulations.Frontiers in pharmacology · 2026Article
- Associations of Serum Testosterone and SHBG With Incident Fractures in Middle-aged to Older Men.The Journal of clinical endocrinology and metabolism · 2025Article
- Age-dependent effect of vitamin D supplementation on musculoskeletal health in chronic spinal cord injury patients: A pilot study.The journal of spinal cord medicine · 2025Article
- Bone turnover markers and muscle decay indicator in patients with proximal femur fracture - a case-control study.Reumatologia · 2024Article
- Differences in the global exposure, mortality and disability of low bone mineral density between men and women: the underestimated burden in men.BMC public health · 2023Article
- SHBG, Bone Mineral Density, and Physical Function Among Injection Drug Users With and Without HIV and HCV.The Journal of clinical endocrinology and metabolism · 2022Article
- Impact of hypogonadism on bone mineral density and vertebral fractures in HIV-infected men.Journal of endocrinological investigation · 2022Article
- Sex-specific differences in bone mineral density loss after sleeve gastrectomy.Frontiers in medicine · 2022Article
- The Role of Sex Hormones on Bone Mineral Density, Marrow Adiposity, and Muscle Adiposity in Middle-Aged and Older Men.Frontiers in endocrinology · 2022Article
- Bone turnover markers as determinants of bone density and fracture in men with distal forearm fractures: the pathogenesis examined in the Mr F study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Article
- Management of osteoporosis in older men.Aging clinical and experimental research · 2021Review
- The risk factors of vertebral refracture after kyphoplasty in patients with osteoporotic vertebral compression fractures: a study protocol for a prospective cohort study.BMC musculoskeletal disorders · 2018Article
- The association of testosterone, sex hormone-binding globulin, and insulin-like growth factor-1 with bone parameters in Korean men aged 50 years or older.Journal of bone and mineral metabolism · 2017Article
- The Limited Clinical Utility of Testosterone, Estradiol, and Sex Hormone Binding Globulin Measurements in the Prediction of Fracture Risk and Bone Loss in Older Men.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- Estrogens and Androgens in Skeletal Physiology and Pathophysiology.Physiological reviews · 2017Review
- SHBG, Sex Steroids, and Kyphosis in Older Men: The MrOS Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016Article
- Sex hormone-binding globulin regulation of androgen bioactivity in vivo: validation of the free hormone hypothesis.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 3 countries.
Funding
Abstract
Previous prospective cohort studies have shown that serum levels of sex steroids and sex hormone-binding globulin (SHBG) associate with nonvertebral fracture risk in men. The predictive value of sex hormones and SHBG for vertebral fracture risk specifically is, however, less studied. Elderly men (aged ≥ 65 years) from Sweden and Hong Kong participating in the Osteoporotic Fractures in Men (MrOS) study had baseline estradiol and testosterone analyzed by gas chromatography-mass spectrometry (GC-MS) and SHBG by immunoradiometric assay (IRMA). Incident clinical vertebral fractures (n = 242 cases) were evaluated in 4324 men during an average follow-up of 9.1 years. In a subsample of these men (n = 2256), spine X-rays were obtained at baseline and after an average follow-up of 4.3 years to identify incident radiographic vertebral fractures (n = 157 cases). The likelihood of incident clinical and radiographic vertebral fractures was estimated by Cox proportional hazards models and logistic regression models, respectively. Neither serum estradiol (hazard ratio [HR] per SD increase = 0.93, 95% confidence interval [CI] 0.80-1.08) nor testosterone (1.05, 0.91-1.21) predicted incident clinical vertebral fractures in age-adjusted models in the combined data set. High serum SHBG, however, associated with increased clinical vertebral fracture risk (1.24, 1.12-1.37). This association remained significant after further adjustment for FRAX with or without bone mineral density (BMD). SHBG also associated with increased incident radiographic vertebral fracture risk (combined data set; odds ratio [OR] per SD increase = 1.23, 95% CI 1.05-1.44). This association remained significant after adjustment for FRAX with or without BMD. In conclusion, high SHBG predicts incident clinical and radiographic vertebral fractures in elderly men and adds moderate information beyond FRAX with BMD for vertebral fracture risk prediction.
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Registered trials
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