ArticleNeuroImage2016
Differential motor and prefrontal cerebello-cortical network development: Evidence from multimodal neuroimaging.
Article in NeuroImage, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review of Cognition in Chiari I Malformation.Neuropsychology review · 2018Pooled it
- Enhancing Balance Control in Aging Through Cerebellar Theta-Burst Stimulation.Cerebellum (London, England) · 2025Trial
- Protracted prediction: Neurodevelopment of reward processing in the adolescent cerebellum.bioRxiv : the preprint server for biology · 2026Article
- Compensatory and Dynamic Cerebellar Responses to Striatal Lesions in Experimental Parkinsonism.Cerebellum (London, England) · 2026Article
- Protocol for the "motor-brain development" trial: effects of motor-focused exercise training on brain function and gross motor skills in preschool children.Frontiers in pediatrics · 2026Article
- Review
- The Influence of Sex and Sex-Steroid Hormones on Cerebellar Structure and Functional Connectivity Across Adulthood.Human brain mapping · 2025Article
- Evaluating Primitive Reflexes in Early Childhood as a Potential Biomarker for Developmental Disabilities.Journal of paediatrics and child health · 2025Review
- Relationships of functional connectivity of motor cortex, primary somatosensory cortex, and cerebellum to balance performance in middle-aged and older adults.Neurobiology of aging · 2025Article
- Functional cerebello-cortico-limbic connectivity in aggression: A resting-state 7T fMRI study in healthy volunteers.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Cerebello-Hippocampal Interactions in the Human Brain: A New Pathway for Insights Into Aging.Cerebellum (London, England) · 2024Review
- Functional connectivity of the sensorimotor cerebellum in autism: associations with sensory over-responsivity.Frontiers in psychiatry · 2024Article
- Increased Cerebello-Prefrontal Connectivity Predicts Poor Executive Function in Congenital Heart Disease.Journal of clinical medicine · 2023Article
- Thalamo-cortical and cerebello-cortical functional connectivity in development.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Age-related differences in resting-state functional connectivity from childhood to adolescence.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Anodal cerebellar stimulation increases cortical activation: Evidence for cerebellar scaffolding of cortical processing.Human brain mapping · 2023Article
- Longitudinal maturation of resting state networks: Relevance to sustained attention and attention deficit/hyperactivity disorder.Cognitive, affective & behavioral neuroscience · 2022Article
- The association of reproductive stage with lobular cerebellar network connectivity across female adulthood.Neurobiology of aging · 2022Article
- Play Smart, Be Smart? Effect of Cognitively Engaging Physical Activity Interventions on Executive Function among Children 4~12 Years Old: A Systematic Review and Meta-Analysis.Brain sciences · 2022Review
- Don't forget the little brain: A framework for incorporating the cerebellum into the understanding of cognitive aging.Neuroscience and biobehavioral reviews · 2022Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
While our understanding of cerebellar structural development through adolescence and young adulthood has expanded, we still lack knowledge of the developmental patterns of cerebellar networks during this critical portion of the lifespan. Volume in lateral posterior cerebellar regions associated with cognition and the prefrontal cortex develops more slowly, reaching their peak volume in adulthood, particularly as compared to motor Lobule V. We predicted that resting state functional connectivity of the lateral posterior regions would show a similar pattern of development during adolescence and young adulthood. That is, we expected to see changes over time in Crus I and Crus II connectivity with the cortex, but no changes in Lobule V connectivity. Additionally, we were interested in how structural connectivity changes in cerebello-thalamo-cortical white matter are related to changes in functional connectivity. A sample of 23 individuals between 12 and 21years old underwent neuroimaging scans at baseline and 12months later. Functional networks of Crus I and Crus II showed significant connectivity decreases over 12months, though there were no differences in Lobule V. Furthermore, these functional connectivity changes were correlated with increases in white matter structural integrity in the corresponding cerebello-thalamo-cortical white matter tract. We suggest that these functional network changes are due to both later pruning in the prefrontal cortex as well as further development of the white matter tracts linking these brain regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.