ReviewThe Journal of physiology2016
Ageing, metabolism and cardiovascular disease.
Review in The Journal of physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03793127 (BAT as a Therapeutic for the Metabolic and Cardiac Dysfunction With Senescence Pilot), which is not on this map. Cited by 265 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
BAT as a Therapeutic for the Metabolic and Cardiac Dysfunction With Senescence Pilot
Who cites it
265 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Arterial stiffness adaptations to chronic resistance and aerobic exercise: a systematic review of exercise modalities.Frontiers in public health · 2025Pooled it
- Pooled it
- The Importance of Activating Factors in Physical Activity Interventions for Older Adults Using Information and Communication Technologies: Systematic Review.JMIR mHealth and uHealth · 2023Pooled it
- Advance care planning for frail elderly: are we missing a golden opportunity? A mixed-method systematic review and meta-analysis.BMJ open · 2023Pooled it
- Effects of Cardiovascular Disease Risk Factors, Musculoskeletal Health, and Physical Fitness on Occupational Performance in Firefighters-A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Pooled it
- Characteristics of Physical Exercise Programs for Older Adults in Latin America: A Systematic Review of Randomized Controlled Trials.International journal of environmental research and public health · 2021Pooled it
- Taurine, Sirtuin-1 and TNF- α levels in different aged adults with periodontitis: a pilot study.BMC oral health · 2025Trial
- The Effect of a Citrus and Pomegranate Complex on Physical Fitness and Mental Well-Being in Healthy Elderly: A Randomized Placebo-Controlled Trial.The journal of nutrition, health & aging · 2022Trial
- Association between the triglyceride-glucose-body mass index and the risk of early vascular aging in young and middle-aged Chinese adults: a cross-sectional study.BMC cardiovascular disorders · 2026Observational
- Intracranial aneurysms as a manifestation of premature vascular aging: Cellular senescence, inflammaging, and wall degeneration.Ageing research reviews · 2026Review
- Age, rather than hypertension duration, drives coronary endothelial degradation: an in situ post-mortem analysis.BMC cardiovascular disorders · 2026Observational
- Modified Sleep Apnea Severity Index and Cardiovascular Risk in CPAP-Intolerant OSA Patients.The Laryngoscope · 2026Article
- Contribution of Sport Type to the Association Between Handgrip Strength and Morbidity/Mortality: Future Follow-up Study and Possible Mechanisms.Sports medicine - open · 2026Review
- Unlocking the aging brain: mTORC1 as a convergent integrator for neurodegeneration and therapeutic intervention.Biogerontology · 2026Review
- Unfavorable cardiovascular risk profile without increased event prevalence in late-onset Pompe disease: an individually matched cohort study.Orphanet journal of rare diseases · 2026Article
- Increased transvascular retention of atherogenic lipoproteins in type 2 diabetes relates to their enhanced proteoglycan binding.JCI insight · 2026Article
- Multitissue, multi-time point transcriptomic atlas of aging in mice and rats.Science advances · 2026Article
- Association Between Parameters of Penile Doppler Ultrasound and Cardiovascular Risk in Patients with Erectile Dysfunction: A Single-Center Retrospective Study.Journal of clinical medicine · 2026Article
- A functionally integrated cross-tissue alternative splicing program during short-term calorie restriction.Life metabolism · 2026Article
205 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Age is one of the major risk factors associated with cardiovascular disease (CVD). About one-fifth of the world population will be aged 65 or older by 2030, with an exponential increase in CVD prevalence. It is well established that environmental factors (overnutrition, smoking, pollution, sedentary lifestyles) may lead to premature defects in mitochondrial functionality, insulin signalling, endothelial homeostasis and redox balance, fostering early senescent features. Over the last few years, molecular investigations have unveiled common signalling networks which may link the ageing process with deterioration of cardiovascular homeostasis and metabolic disturbances, namely insulin resistance. These different processes seem to be highly interconnected and their interplay may favour adverse vascular and cardiac phenotypes responsible for myocardial infarction, stroke and heart failure. In the present review, we carefully describe novel molecular cues underpinning ageing, metabolism and CVD. In particular, we describe a dynamic interplay between emerging pathways such as FOXOs, AMPK, SIRT1, p66(Shc) , JunD and NF-kB. This overview will provide the background for attractive molecular targets to prevent age-driven pathology in the vasculature and the heart.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.