ArticleNature chemistry2015
A cascade reaction network mimicking the basic functional steps of adaptive immune response.
Article in Nature chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Nucleic acid aptamers: new methods for selection, target validation, molecular diagnostics and therapeutics.Signal transduction and targeted therapy · 2026Review
- Engineering Artificial Mitochondria with Self-Amplifying Proton Generation for Autonomous Energy Supply and Metabolic Coupling in Artificial Cells.Angewandte Chemie (International ed. in English) · 2025Article
- Cell-Membrane-Anchored Synthetic Dynamic DNA Circuits for Signaling Transient Cell Migration.Journal of the American Chemical Society · 2025Article
- AI driven network pharmacology: Multi-scale mechanisms of traditional Chinese medicine from molecular to patient analysis.Computational and structural biotechnology journal · 2025Review
- Genetically programmed synthetic cells for thermo-responsive protein synthesis and cargo release.Nature chemical biology · 2024Article
- Collective Molecular Machines: Multidimensionality and Reconfigurability.Nano-micro letters · 2024Review
- Controllable mitochondrial aggregation and fusion by a programmable DNA binder.Chemical science · 2023Article
- Cascade nanozymatic network mimicking cells with selective and linear perception of HChemical science · 2023Article
- Cascaded, Feedback-Driven, and Spatially Localized Emergence of Constitutional Dynamic Networks Driven by Enzyme-Free Catalytic DNA Circuits.Journal of the American Chemical Society · 2023Article
- DNA-Based Molecular Machines.JACS Au · 2022Review
- An automated DNA computing platform for rapid etiological diagnostics.Science advances · 2022Article
- Identifying and Differentiating Topological G-Quadruplex Structures with DNA-Encoded Plasmonic Gold Nanoparticles.Angewandte Chemie (International ed. in English) · 2022Article
- Network topology-directed design of molecular CPU for cell-like dynamic information processing.Science advances · 2022Article
- Cancer diagnosis with DNA molecular computation.Nature nanotechnology · 2020Article
- DNA-based artificial molecular signaling system that mimics basic elements of reception and response.Nature communications · 2020Article
- Protocells programmed through artificial reaction networks.Chemical science · 2019Review
- Artificial Signal Feedback Network Mimicking Cellular Adaptivity.Journal of the American Chemical Society · 2019Article
- Solving mazes with single-molecule DNA navigators.Nature materials · 2019Article
- Engineering a 3D DNA-Logic Gate Nanomachine for Bispecific Recognition and Computing on Target Cell Surfaces.Journal of the American Chemical Society · 2018Article
- DNA-Based Dynamic Reaction Networks.Trends in biochemical sciences · 2018Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Biological systems use complex 'information-processing cores' composed of molecular networks to coordinate their external environment and internal states. An example of this is the acquired, or adaptive, immune system (AIS), which is composed of both humoral and cell-mediated components. Here we report the step-by-step construction of a prototype mimic of the AIS that we call an adaptive immune response simulator (AIRS). DNA and enzymes are used as simple artificial analogues of the components of the AIS to create a system that responds to specific molecular stimuli in vitro. We show that this network of reactions can function in a manner that is superficially similar to the most basic responses of the vertebrate AIS, including reaction sequences that mimic both humoral and cellular responses. As such, AIRS provides guidelines for the design and engineering of artificial reaction networks and molecular devices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.