ArticleNature chemistry2015
Iterative exponential growth of stereo- and sequence-controlled polymers.
Article in Nature chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
70 citing papers in PubMed, 341 citations in OpenAlex.
- Degradable Alternating Copolymers With Strained Cyclobutane Backbones via Photocontrolled RAFT Polymerization.Angewandte Chemie (International ed. in English) · 2026Article
- The Impact of Copolymer Molecular Sequence on Electronic Transport.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Sequence-defined polymers for predictable gene delivery.Nature reviews. Chemistry · 2026Review
- Lipid nanoparticle formulations including stereochemically defined glycomacromolecules for delivery of saRNA.Chemical science · 2026Article
- Hierarchical Chiral Self-Assembly of Nanocylinders Composed of Sequence-Defined Mesogenic Dimers.Journal of the American Chemical Society · 2026Article
- Stereocontrol as a tool for shaping abiotic, sequence-defined oligourethanes.Polymer chemistry · 2026Article
- Characterization of Sequence Distributions in Random and Semi-Random Copolymers.Macromolecules · 2026Article
- Synergizing Chemical and AI Communities for Advancing Laboratories of the Future.ACS central science · 2026Review
- One-pot synthesis of sequence-controlled macromonomersChemical science · 2025Article
- Supramolecular bending and twisting in the hierarchical self-assembly of monodisperse mesogenic oligomers.Science advances · 2025Article
- Sequence-defined peptoidsChemical science · 2025Article
- Expeditious chemical synthesis of xylomannans disproves the proposed antifreeze activities.National science review · 2024Article
- Stabilizing hexagonally close-packed phase in single-component block copolymers through rational symmetry breaking.Nature communications · 2024Article
- Chromatographic Separation: A Versatile Strategy to Prepare Discrete and Well-Defined Polymer Libraries.Accounts of chemical research · 2024Article
- High-Throughput Synthesis, Purification, and Application of Alkyne-Functionalized Discrete Oligomers.Journal of the American Chemical Society · 2024Article
- Click processes orthogonal to CuAAC and SuFEx forge selectively modifiable fluorescent linkers.Nature chemistry · 2024Article
- Surface-confined alternating copolymerization with molecular precision by stoichiometric control.Nature communications · 2024Article
- Synthetically encoded complementary oligomers.Nature reviews. Chemistry · 2023Review
- Dynamic self-assembly of supramolecular catalysts from precision macromolecules.Chemical science · 2023Article
- Backbone Engineering of Monodisperse Conjugated Polymers via Integrated Iterative Binomial Synthesis.Journal of the American Chemical Society · 2023Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Chemists have long sought sequence-controlled synthetic polymers that mimic nature's biopolymers, but a practical synthetic route that enables absolute control over polymer sequence and structure remains a key challenge. Here, we report an iterative exponential growth plus side-chain functionalization (IEG+) strategy that begins with enantiopure epoxides and facilitates the efficient synthesis of a family of uniform >3 kDa macromolecules of varying sequence and stereoconfiguration that are coupled to produce unimolecular polymers (>6 kDa) with sequences and structures that cannot be obtained using traditional polymerization techniques. Selective side-chain deprotection of three hexadecamers is also demonstrated, which imbues each compound with the ability to dissolve in water. We anticipate that these new macromolecules and the general IEG+ strategy will find broad application as a versatile platform for the scalable synthesis of sequence-controlled polymers.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.