ArticleIEEE transactions on biomedical circuits and systems2016
Neurochemostat: A Neural Interface SoC With Integrated Chemometrics for Closed-Loop Regulation of Brain Dopamine.
Article in IEEE transactions on biomedical circuits and systems, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Machine Learning for Neurotransmitter Monitoring by Fast Voltammetry: Current and Future Prospects.ACS chemical neuroscience · 2026Review
- Development of a Smart Wireless Multisensor Platform for an Optogenetic Brain Implant.Sensors (Basel, Switzerland) · 2024Article
- SmartFSCV: An Artificial Intelligence Enabled Miniaturised FSCV Device Targeting Serotonin.IEEE open journal of engineering in medicine and biology · 2024Article
- Hybrid Neural Autoencoders for Stimulus Encoding in Visual and Other Sensory Neuroprostheses.Advances in neural information processing systems · 2022Article
- Evaluation of electrochemical methods for tonic dopamine detectionTrends in analytical chemistry : TRAC · 2020Article
- Advances in neurochemical measurements: A review of biomarkers and devices for the development of closed-loop deep brain stimulation systems.Reviews in analytical chemistry · 2020Article
- Closed-Loop Implantable Therapeutic Neuromodulation Systems Based on Neurochemical Monitoring.Frontiers in neuroscience · 2019Review
- A Bidirectional-Current CMOS Potentiostat for Fast-Scan Cyclic Voltammetry Detector Arrays.IEEE transactions on biomedical circuits and systems · 2018Article
- An investigation into closed-loop treatment of neurological disorders based on sensing mitochondrial dysfunction.Journal of neuroengineering and rehabilitation · 2018Review
- Fast-Scan Cyclic Voltammetry: Chemical Sensing in the Brain and Beyond.Analytical chemistry · 2018Review
- Hybrid CMOS-Graphene Sensor Array for Subsecond Dopamine Detection.IEEE transactions on biomedical circuits and systems · 2017Article
- Miniaturized FDDA and CMOS Based Potentiostat for Bio-Applications.Sensors (Basel, Switzerland) · 2017Article
- Neurochemostat: A Neural Interface SoC With Integrated Chemometrics for Closed-Loop Regulation of Brain Dopamine.IEEE transactions on biomedical circuits and systems · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
This paper presents a 3.3×3.2 mm(2) system-on-chip (SoC) fabricated in AMS 0.35 μm 2P/4M CMOS for closed-loop regulation of brain dopamine. The SoC uniquely integrates neurochemical sensing, on-the-fly chemometrics, and feedback-controlled electrical stimulation to realize a "neurochemostat" by maintaining brain levels of electrically evoked dopamine between two user-set thresholds. The SoC incorporates a 90 μW, custom-designed, digital signal processing (DSP) unit for real-time processing of neurochemical data obtained by 400 V/s fast-scan cyclic voltammetry (FSCV) with a carbon-fiber microelectrode (CFM). Specifically, the DSP unit executes a chemometrics algorithm based upon principal component regression (PCR) to resolve in real time electrically evoked brain dopamine levels from pH change and CFM background-current drift, two common interferents encountered using FSCV with a CFM in vivo. Further, the DSP unit directly links the chemically resolved dopamine levels to the activation of the electrical microstimulator in on-off-keying (OOK) fashion. Measured results from benchtop testing, flow injection analysis (FIA), and biological experiments with an anesthetized rat are presented.
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Registered trials
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