Evidence map›Paper›PMID 26390357›Full record

ArticleMagnetic resonance in medicine2015

Quantifying temperature-dependent T1 changes in cortical bone using ultrashort echo-time MRI.

Misung Han, Viola Rieke, Serena J Scott, Eugene Ozhinsky, Vasant A Salgaonkar, Peter D Jones, Peder E Z Larson, Chris J Diederich, Roland Krug

Open access · greenAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Misung HanDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.ORCID http://orcid.org/0000-0003-0918-8831
Viola RiekeDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
Serena J ScottDepartment of Radiation Oncology, University of California, San Francisco, San Francisco, California, USA.
Eugene OzhinskyDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
Vasant A SalgaonkarDepartment of Radiation Oncology, University of California, San Francisco, San Francisco, California, USA.
Peter D JonesDepartment of Radiation Oncology, University of California, San Francisco, San Francisco, California, USA.
Peder E Z LarsonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
Chris J DiederichDepartment of Radiation Oncology, University of California, San Francisco, San Francisco, California, USA.
Roland KrugDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
University of California, San Francisco · USQB3 · US

Funding

Ultrasound Ablation on Bone Cancer Under CT FluoroscopyR44CA112852 · NCI · ACOUSTIC MEDSYSTEMS, INC. · PI BURDETTE, EVERETTE C · 2010 to 2012
$3.1M
UCSF Core Center for Musculoskeletal Biology and MedicineP30AR066262 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MAJUMDAR, SHARMILA · 2014 to 2018
$3.0M
In Vivo Assessment of Trabecular Microstructure at the Proximal FemurR01AR057336 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRUG, ROLAND · 2009 to 2012
$1.1M
MRI-Guided Cardiac Focused Ultrasound AblationR00HL097030 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RIEKE, VIOLA · 2012 to 2015
$724k
NCI NIH HHS R44 CA112852NHLBI NIH HHS R00 HL097030NHLBI NIH HHS R00HL097030NIAMS NIH HHS P30 AR066262NIAMS NIH HHS R01 AR057336NIAMS NIH HHS R01AR057336
6 · The paper itself

Abstract

purposeTo demonstrate the feasibility of using ultrashort echo-time MRI to quantify T1 changes in cortical bone due to heating.

methodsVariable flip-angle T1 mapping combined with 3D ultrashort echo-time imaging was used to measure T1 in cortical bone. A calibration experiment was performed to detect T1 changes with temperature in ex vivo cortical bone samples from a bovine femur. Ultrasound heating experiments were performed using an interstitial applicator in ex vivo bovine femur specimens, and heat-induced T1 changes were quantified.

resultsThe calibration experiment demonstrated that T1 increases with temperature in cortical bone. We observed a linear relationship between temperature and T1 with a linear coefficient between 0.67 and 0.84 ms/°C over a range of 25-70°C. The ultrasound heating experiments showed increased T1 changes in the heated regions, and the relationship between the temperature changes and T1 changes was similar to that of the calibration.

conclusionWe demonstrated a temperature dependence of T1 in ex vivo cortical bone using a variable flip-angle ultrashort echo-time T1 mapping method.

Indexed as

AnimalsBody TemperatureCattleFeasibility StudiesFemurHeatingHigh-Energy Shock WavesImage Interpretation, Computer-AssistedImaging, Three-DimensionalIn Vitro TechniquesMagnetic Resonance ImagingReproducibility of ResultsSensitivity and SpecificityThermographycortical boneMR temperature mappingT1 mappingUTE imaging

Identifiers

PMID26390357
PMCPMC4715675
OpenAlexW1928764980

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.