Evidence map›Paper›PMID 26390057›Full record

ArticleNature genetics2015

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.

Norihiro Kato, Marie Loh, Fumihiko Takeuchi, Niek Verweij, Xu Wang, Weihua Zhang, Tanika N Kelly, Danish Saleheen, Benjamin Lehne, Irene Mateo Leach and 238 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 223 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
223citing papers in PubMed, 18 pooled it
34.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

223 citing papers in PubMed, 18 syntheses or guidelines pooled it, 372 citations in OpenAlex.

  1. Pooled it
  2. Accelerated epigenetic age in hypertension: a systematic review and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
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  12. The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019).Hypertension research : official journal of the Japanese Society of Hypertension · 2019
    Guideline
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  19. Trial
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163 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

248 authors at 20 institutions in 27 countries.

Norihiro Kato *Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Marie Loh *Institute of Health Sciences, University of Oulu, Oulu, Finland.
Fumihiko Takeuchi *Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Niek Verweij *Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Xu Wang *Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
Weihua Zhang *Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
Tanika N Kelly *Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
Danish Saleheen *Center for Non-Communicable Diseases, Karachi, Pakistan.
Benjamin Lehne *Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
Irene Mateo Leach *Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Alexander W DrongWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
James AbbottBioinformatics Support Service, Imperial College London, London, UK.
Simone WahlResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Sian-Tsung TanEaling Hospital National Health Service (NHS) Trust, Middlesex, UK.
William R ScottDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.
Gianluca CampanellaDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.
Marc Chadeau-HyamDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.
Uzma AfzalDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.
Tarunveer S AhluwaliaNovo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Marc Jan BonderDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Peng ChenSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
Abbas DehghanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Todd L EdwardsVanderbilt Epidemiology Center, Center for Human Genetics Research, Division of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
Tõnu EskoEstonian Genome Center, University of Tartu, Tartu, Estonia.
Min Jin GoCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Sarah E HarrisMedical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine and Medical Research Council (MRC) Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK.
Jaana HartialaDepartment of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Silva KaselaEstonian Genome Center, University of Tartu, Tartu, Estonia.
Anuradhani KasturiratneDepartment of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Chiea-Chuen KhorSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
Marcus E KleberMedical Clinic V, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany.
Huaixing LiKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Zuan Yu MokCancer Science Institute of Singapore, National University of Singapore, Singapore.
Masahiro NakatochiCenter for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan.
Nur Sabrina SapariCancer Science Institute of Singapore, National University of Singapore, Singapore.
Richa SaxenaCenter for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Alexandre F R StewartUniversity of Ottawa Heart Institute, Cardiovascular Research Methods Centre, Ottawa, Ontario, Canada.
Lisette StolkDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
Yasuharu TabaraCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Ai Ling TehSingapore Institute for Clinical Sciences (SICS), ASTAR, Singapore.
Ying WuDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.
Jer-Yuarn WuInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Yi ZhangState Key Laboratory of Medical Genetics, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Imke AitsInstitute of Epidemiology and Biobank popgen, Christian Albrechts University of Kiel, Kiel, Germany.
Alexessander Da Silva Couto AlvesDepartment of Epidemiology and Biostatistics, MRC Health Protection Agency (PHE) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Shikta DasDepartment of Epidemiology and Biostatistics, MRC Health Protection Agency (PHE) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Rajkumar DorajooGenome Institute of Singapore, ASTAR, Singapore.
Jemma C HopewellClinical Trials Support Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Yun Kyoung KimCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Robert W KoivulaDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden.
Jian'an LuanMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Quang N NguyenVietnam National Heart Institute, Bach Mai Hospital, Hanoi, Vietnam.
Mark A PereiraSchool of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
Iris PostmusDepartment of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
Molly Scannell Bryan *Department of Public Health Sciences, University of Chicago, Chicago, Illinois, USA.
Robert A ScottMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Rossella SoriceInstitute of Genetics and Biophysics A Buzzati-Traverso, CNR, Naples, Italy.
Vinicius TraganteDivision of Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Michela TragliaDivision of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.
Jon WhiteUniversity College London Genetics Institute, Department of Genetics, Environment and Evolution, University College London, London, UK.
Ken YamamotoDivision of Genomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Yonghong ZhangDepartment of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.
Linda S AdairDepartment of Nutrition, University of North Carolina, Chapel Hill, North Carolina, USA.
Alauddin AhmedUChicago Research Bangladesh, Uttara, Dhaka, Bangladesh.
Koichi AkiyamaDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Rasheed AsifCenter for Non-Communicable Diseases, Karachi, Pakistan.
Tin AungSingapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Inês BarrosoMetabolic Disease Group, Wellcome Trust Sanger Institute, Cambridge, UK.
Andrew BjonnesCenter for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Timothy R BraunDepartment of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Hui CaiVanderbilt Epidemiology Center, Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee, USA.
Li-Ching ChangInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Chien-Hsiun ChenInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Ching-Yu ChengSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
Yap-Seng ChongSingapore Institute for Clinical Sciences (SICS), ASTAR, Singapore.
Rory CollinsClinical Trials Support Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Regina CourtneyVanderbilt Epidemiology Center, Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee, USA.
Gail DaviesCentre for Cognitive Aging and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Graciela DelgadoMedical Clinic V, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany.
Loi D DoVietnam National Heart Institute, Bach Mai Hospital, Hanoi, Vietnam.
Pieter A DoevendansDivision of Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Ron T GansevoortDepartment of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Yu-Tang GaoDepartment of Epidemiology, Shanghai Cancer Institute, Shanghai, China.
Tanja B GrammerMedical Clinic V, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany.
Niels GrarupNovo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jagvir GrewalDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.
Dongfeng GuFu Wai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Gurpreet S WanderDayanand Medical College and Hospital Unit, Hero DMC Heart Institute, Ludhiana, India.
Anna-Liisa HartikainenDepartment of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland.
Stanley L HazenDepartment of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Jing HeDepartment of Biostatistics, Vanderbilt University, Nashville, Tennessee, USA.
Chew-Kiat HengDepartment of Paediatrics, Yong Loo Lin School of Medicine, Singapore.
James E HixsonHuman Genetics Center, University of Texas School of Public Health at Houston, Houston, Texas, USA.
Albert HofmanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Chris HsuUniversity of Southern California Keck School of Medicine, Los Angeles, California, USA.
Wei HuangDepartment of Genetics, Chinese National Human Genomic Center, Shanghai, China.
Lise L N HusemoenResearch Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark.
Joo-Yeon HwangCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Sahoko IchiharaGraduate School of Regional Innovation Studies, Mie University, Tsu, Japan.
Michiya IgaseDepartment of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
Masato IsonoDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Johanne M JustesenNovo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Tomohiro KatsuyaDepartment of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan.
Muhammad G KibriyaDepartment of Public Health Sciences, University of Chicago, Chicago, Illinois, USA.
Young Jin KimCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Miyako KishimotoNational Center for Global Health and Medicine, Toyama, Japan.
Woon-Puay KohSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
Katsuhiko KoharaDepartment of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
Meena KumariDepartment of Epidemiology and Public Health, University College London, London, UK.
Kenneth KwekK.K. Women's and Children's Hospital, Singapore.
Nanette R LeeUniversity of San Carlos Office of Population Studies Foundation, University of San Carlos, Cebu City, Philippines.
Jeannette LeeSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
Jiemin LiaoDepartment of Ophthalmology, National University of Singapore, Singapore.
Wolfgang LiebInstitute of Epidemiology and Biobank popgen, Christian Albrechts University of Kiel, Kiel, Germany.
David C M LiewaldCentre for Cognitive Aging and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Tatsuaki MatsubaraDepartment of Internal Medicine, Aichi-Gakuin University School of Dentistry, Nagoya, Japan.
Yumi MatsushitaNational Center for Global Health and Medicine, Toyama, Japan.
Thomas MeitingerInstitute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Evelin MihailovEstonian Genome Center, University of Tartu, Tartu, Estonia.
Lili MilaniEstonian Genome Center, University of Tartu, Tartu, Estonia.
Rebecca MillsEaling Hospital National Health Service (NHS) Trust, Middlesex, UK.
Nina MononenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Martina Müller-NurasyidInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Toru NabikaDepartment of Functional Pathology, Shimane University Faculty of Medicine, Izumo, Japan.
Eitaro NakashimaDivision of Endocrinology and Diabetes, Department of Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Hong Kiat NgCancer Science Institute of Singapore, National University of Singapore, Singapore.
Kjell NikusHeart Centre, Department of Cardiology, Tampere University Hospital and University of Tampere School of Medicine, Tampere, Finland.
Teresa NutileInstitute of Genetics and Biophysics A Buzzati-Traverso, CNR, Naples, Italy.
Takayoshi OhkuboDepartment of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan.
Keizo OhnakaDepartment of Geriatric Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Sarah ParishClinical Trials Support Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Lavinia PaternosterMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Hao PengDepartment of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.
Annette PetersInstitute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Son T PhamVietnam National Heart Institute, Bach Mai Hospital, Hanoi, Vietnam.
Mohitha J PinidiyapathirageDepartment of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Mahfuzar RahmanUChicago Research Bangladesh, Uttara, Dhaka, Bangladesh.
Hiromi RakugiDepartment of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Japan.
Olov RolandssonDepartment of Public Health and Clinical Medicine, Section for Family Medicine, Umeå Universitet, Umeå, Sweden.
Michelle Ann RozarioCancer Science Institute of Singapore, National University of Singapore, Singapore.
Daniela RuggieroInstitute of Genetics and Biophysics A Buzzati-Traverso, CNR, Naples, Italy.
Cinzia F SalaDivision of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.
Ralhan SarjuDayanand Medical College and Hospital Unit, Hero DMC Heart Institute, Ludhiana, India.
Kazuro ShimokawaDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Thomas SparsøNovo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Wilko SpieringDepartment of Vascular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
John M StarrCentre for Cognitive Aging and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
David J StottAcademic Section of Geriatric Medicine, Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, UK.
Daniel O StramUniversity of Southern California Keck School of Medicine, Los Angeles, California, USA.
Takao SugiyamaInstitute for Adult Diseases, Asahi Life Foundation, Tokyo, Japan.
Silke SzymczakInstitute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.
W H Wilson TangDepartment of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Lin TongDepartment of Public Health Sciences, University of Chicago, Chicago, Illinois, USA.
Stella TrompetDepartment of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
Väinö TurjanmaaDepartment of Clinical Physiology, Tampere University Hospital, Tampere, Finland.
Hirotsugu UeshimaDepartment of Health Science, Shiga University of Medical Science, Otsu, Japan.
André G UitterlindenDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Satoshi UmemuraDepartment of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Marja VaarasmakiDepartment of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland.
Rob M van DamSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
Wiek H van GilstDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Dirk J van VeldhuisenDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Jorma S ViikariDivision of Medicine, Turku University Hospital, Turku, Finland.
Melanie WaldenbergerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Yiqin WangKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Aili WangDepartment of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.
Rory WilsonResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Tien-Yin WongDepartment of Ophthalmology, National University of Singapore, Singapore.
Yong-Bing XiangDepartment of Epidemiology, Shanghai Cancer Institute, Shanghai, China.
Shuhei YamaguchiThird Department of Internal Medicine, Shimane University Faculty of Medicine, Izumo, Japan.
Xingwang YeKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Robin D YoungDepartment of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
Terri L YoungNeuroscience and Behavioural Disorders (NBD) Program, Duke-National University of Singapore Graduate Medical School, Singapore.
Jian-Min YuanCancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA.
Xueya ZhouBioinformatics Division, Tsinghua National Laboratory for Informatics Science and Technology (TNLIST), Ministry of Education Key Laboratory of Bioinformatics, Department of Automation, Tsinghua University, Beijing, China.
Folkert W AsselbergsDivision of Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Marina CiulloInstitute of Genetics and Biophysics A Buzzati-Traverso, CNR, Naples, Italy.
Robert ClarkeClinical Trials Support Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Panos DeloukasWilliam Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Andre FrankeInstitute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.
Paul W FranksDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden.
Steve FranksInstitute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London, UK.
Yechiel FriedlanderHebrew University, School of Public Health, Jerusalem, Israel.
Myron D GrossSchool of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Zhirong GuoDepartment of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China.
Torben HansenNovo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Marjo-Riitta JarvelinInstitute of Health Sciences, University of Oulu, Oulu, Finland.
Torben JørgensenResearch Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, Tampere, Finland.
Hiroshi KajioNational Center for Global Health and Medicine, Toyama, Japan.
Mika KivimakiDepartment of Epidemiology and Public Health, University College London, London, UK.
Jong-Young LeeMinistry of Health and Welfare, Seoul, Republic of Korea.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Allan LinnebergResearch Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark.
Tetsuro MikiDepartment of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
Oluf PedersenNovo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK.
Thorkild I A SørensenNovo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Ryoichi TakayanagiDepartment of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Kyushu, Japan.
Daniela TonioloDivision of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.
BIOS-consortium
CARDIo GRAMplusCD
LifeLines Cohort Study
InterAct Consortium
Habibul AhsanDepartment of Public Health Sciences, University of Chicago, Chicago, Illinois, USA.
Hooman AllayeeDepartment of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Yuan-Tsong ChenInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
John DaneshDepartment of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
Ian J DearyCentre for Cognitive Aging and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Oscar H FrancoDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Lude FrankeDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Bastiaan T HeijmanMolecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Joanna D HolbrookSingapore Institute for Clinical Sciences (SICS), ASTAR, Singapore.
Aaron IsaacsDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Bong-Jo KimCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Xu LinKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Jianjun LiuSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
Winfried MärzMedical Clinic V, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany.
Andres MetspaluEstonian Genome Center, University of Tartu, Tartu, Estonia.
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.
Dharambir K SangheraDepartment of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Xiao-Ou ShuVanderbilt Epidemiology Center, Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee, USA.
Joyce B J van MeursDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
Eranga VithanaDepartment of Ophthalmology, National University of Singapore, Singapore.
Ananda R WickremasingheDepartment of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Cisca WijmengaDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Bruce H W WolffenbuttelDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Mitsuhiro YokotaDepartment of Genome Science, Aichi-Gakuin University School of Dentistry, Nagoya, Japan.
Wei ZhengVanderbilt Epidemiology Center, Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee, USA.
Dingliang ZhuState Key Laboratory of Medical Genetics, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Paolo VineisDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.
Soterios A KyrtopoulosNational Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, Athens, Greece.
Jos C S KleinjansDepartment of Toxicogenomics, Maastricht University, Maastricht, the Netherlands.
Mark I McCarthyWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Richie SoongCancer Science Institute of Singapore, National University of Singapore, Singapore.
Christian GiegerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
James ScottNational Heart and Lung Institute, Imperial College London, London, UK.
Yik-Ying Teo *Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
Jiang He *Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
Paul Elliott *Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
E Shyong Tai *Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
Pim van der Harst *Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Jaspal S Kooner *Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK.
John C Chambers *Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
National University of Singapore · SGUniversity Medical Center Groningen · NLNational Health Service · GBUniversity of Copenhagen · DKAgency for Science, Technology and Research · SGTampere University · FIUniversity of Southern California · USUniversity of Cambridge · GBHarvard University · USHelmholtz Zentrum München · DENational Center for Global Health and Medicine · JPUniversity of North Carolina at Chapel Hill · USChicago Department of Public Health · USChinese Academy of Sciences · CNKyushu University · JPTulane University · USUniversity Medical Center Utrecht · NLCentre for Human Genetics · GBCleveland Clinic · USLeiden University Medical Center · NL

Funding

Training CoreP42ES010349 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI NAVAS-ACIEN, ANA · 2000 to 2020
$53.6M
Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian Michael Carroll · 1999 to 2026
$31.6M
Structural Determinants Of Ceruloplasmin Inflammatory ActivityP01HL076491 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI PLOW, EDWARD FRANKLIN · 2004 to 2019
$27.3M
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6 · The paper itself

Abstract

We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10(-11) to 5.0 × 10(-21)). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNA methylation may lie on the regulatory pathway linking sequence variation to blood pressure. The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function. The new and known genetic variants predict increased left ventricular mass, circulating levels of NT-proBNP, and cardiovascular and all-cause mortality (P = 0.04 to 8.6 × 10(-6)). Our results provide new evidence for the role of DNA methylation in blood pressure regulation.

Indexed as

DNA MethylationAdultAgedAged, 80 and overAsian PeopleBlood PressureCardiovascular DiseasesFemaleGenetic LociGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyGenotypeHumansMaleMiddle AgedNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)

Identifiers

PMID26390057
PMCPMC4719169
OpenAlexW2107139378

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.