SynthesisNutrients2015
The Relationship between Serum Zinc Level and Preeclampsia: A Meta-Analysis.
Synthesis in Nutrients, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 4 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Association between biomarkers of zinc and copper status and heart failure: a meta-analysis.ESC heart failure · 2024Pooled it
- Maternal serum zinc level is associated with risk of preeclampsia: A systematic review and meta-analysis.Frontiers in public health · 2022Pooled it
- Cord blood zinc status effects on pregnancy outcomes and its relation with maternal serum zinc levels: a systematic review and meta-analysis.World journal of pediatrics : WJP · 2020Pooled it
- Association between Maternal Zinc Status, Dietary Zinc Intake and Pregnancy Complications: A Systematic Review.Nutrients · 2016Pooled it
- Serum Magnesium and Zinc Levels in Pregnant Women with Preeclampsia Compared to Healthy Controls: Case-Control Study.Biological trace element research · 2026Article
- Calcium and zinc status and risk of preeclampsia in pregnant women with varying seafood intake in Ambon City: a case-control study.BMC research notes · 2026Observational
- The immune checkpoint pathophysiology of depression and chronic fatigue syndrome due to preeclampsia: focus on sCD80 and sCTLA-4.Acta neuropsychiatrica · 2025Article
- Associations of Maternal Prenatal Zinc Consumption with Infant Brain Tissue Organization and Neurodevelopmental Outcomes.Nutrients · 2025Article
- Characterization of Mild Delayed Gestational Hypertension in Rats Following Ozone Exposure.Cardiovascular toxicology · 2024Article
- An exploratory study on the association of multiple metals in serum with preeclampsia.Frontiers in public health · 2024Article
- An evidence review and nutritional conceptual framework for pre-eclampsia prevention.The British journal of nutrition · 2023Review
- The association between dietary mineral intake and the risk of preeclampsia in Chinese pregnant women: a matched case-control study.Scientific reports · 2023Article
- Analysis of serum calcium, sodium, potassium, zinc, and iron in patients with pre-eclampsia in Bangladesh: A case-control study.Health science reports · 2023Article
- Targeting the Platelet-Activating Factor Receptor (PAF-R): Antithrombotic and Anti-Atherosclerotic Nutrients.Nutrients · 2022Review
- Maternal nutritional risk factors for pre-eclampsia incidence: findings from a narrative scoping review.Reproductive health · 2022Article
- Article
- Evidence-Based Recommendations for an Optimal Prenatal Supplement for Women in the U.S., Part Two: Minerals.Nutrients · 2021Review
- Zinc and Magnesium Levels of Pregnant Women with Restless Leg Syndrome and Their Relationship with Anxiety: A Case-Control Study.Biological trace element research · 2021Article
- Preeclampsia: From Cellular Wellness to Inappropriate Cell Death, and the Roles of Nutrition.Frontiers in cell and developmental biology · 2021Review
- Zinc.Advances in food and nutrition research · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The association between serum zinc level and preeclampsia (PE) remains controversial. A systematic literature search was performed in PubMed, Web of Science and Embase for relevant available articles. The articles were limited to those in English from January 1990 to April 2015. Observational studies evaluating the association between serum zinc level and PE were included. The I² was used to assess heterogeneity and the random effect model (REM) was adopted as the pooling method. The pooled standard mean difference (SMD) with 95% confidence interval (CI) was used to estimate the association between serum zinc level and PE. Seventeen observational studies were included. Compared with healthy pregnancy controls, PE patients have lower serum zinc level in 14 studies about total PE (SMD (95% CI): -0.587 (-0.963, -0.212), Z = 3.06, p for Z = 0.002; I² = 88.4%, p for I² < 0.0001). In subgroup analysis, a lower serum zinc level in PE patients compared with healthy pregnancy controls was observed in studies conducted in Asia, studies with zinc level measured in serum, and studies involving fasting participants. The SMD did not differ significantly between studies with healthy pregnancy controls matched by individual age (yes or no), and by individual gestational age (yes or no), respectively. Results from this meta-analysis indicate that serum zinc level in PE patients is significantly lower than that in healthy pregnancy controls. A moderate amount of zinc supplementation during pregnancy is advocated to reduce the incidence of PE.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.