ArticleNutrients2015
Cutaneous Manifestations of Non-Celiac Gluten Sensitivity: Clinical Histological and Immunopathological Features.
Article in Nutrients, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- Atopy and Other Sensitivities in Non-Celiac Wheat Sensitivity: Is There an Associated Hypersensitivity Background?Nutrients · 2026Article
- Gluten intake and its possible relationship with pain, skin symptoms, and mental health in the Spanish population: an observational study.Frontiers in nutrition · 2026Article
- Non-Coeliac Wheat Sensitivity: Symptoms in Search of a Mechanism, or a Distinct Well-Defined Clinical Entity? A Narrative Review.International journal of molecular sciences · 2025Review
- Investigating Non-celiac Wheat Sensitivity: A Comprehensive Review of Pathophysiology Underlying Clinical Implications.Clinical reviews in allergy & immunology · 2025Review
- Self-Reported Non-Celiac Wheat Sensitivity and Other Food Sensitivities in Patients with Primary Sjögren's Syndrome.Nutrients · 2025Article
- Gluten-related skin disorders: clinical presentation, diagnostic and treatments.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2025Review
- Improving the Diagnosis of Dermatitis Herpetiformis Using the Intraepithelial Lymphogram.Nutrients · 2024Article
- Review
- Skin gluten-related disorders: new and old cutaneous manifestations to be considered.Frontiers in medicine · 2023Review
- [Dermatitis herpetiformis and other forms of wheat sensitivity].Dermatologie (Heidelberg, Germany) · 2022Review
- Reply letter to "An update on direct immunofluorescence for diagnosing dermatitis herpetiformis". Could granular C3 deposits at the dermal epidermal junction be considered a marker of "cutaneous gluten sensitivity"?Postepy dermatologii i alergologii · 2021Article
- Non-celiac wheat sensitivity: rationality and irrationality of a gluten-free diet in individuals affected with non-celiac disease: a review.BMC gastroenterology · 2021Review
- Co-morbidities associated with non-coeliac gluten sensitivity.Gastroenterology and hepatology from bed to bench · 2021Article
- Beyond the HLA Genes in Gluten-Related Disorders.Frontiers in nutrition · 2020Review
- An update on direct immunofluorescence for diagnosing dermatitis herpetiformis.Postepy dermatologii i alergologii · 2019Review
- Gluten Vehicle and Placebo for Non-Celiac Gluten Sensitivity Assessment.Medicina (Kaunas, Lithuania) · 2019Review
- Nonceliac Wheat Sensitivity: An Immune-Mediated Condition with Systemic Manifestations.Gastroenterology clinics of North America · 2019Review
- Dermatitis Herpetiformis: Novel Perspectives.Frontiers in immunology · 2019Review
- Predictivity of Autoimmune Stigmata for Gluten Sensitivity in Subjects with Microscopic Enteritis: A Retrospective Study.Nutrients · 2018Article
- Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe dermatological manifestations associated with intestinal diseases are becoming more frequent, especially now when new clinical entities, such as Non-Celiac Gluten Sensitivity (NCGS), are identified. The existence of this new entity is still debated. However, many patients with diagnosed NCGS that present intestinal manifestations have skin lesions that need appropriate characterization.
methodsWe involved 17 patients affected by NCGS with non-specific cutaneous manifestations who got much better after a gluten free diet. For a histopathological and immunopathological evaluation, two skin samples from each patient and their clinical data were collected.
resultsThe median age of the 17 enrolled patients affected by NCGS was 36 years and 76% of them were females. On the extensor surfaces of upper and lower limbs in particular, they all presented very itchy dermatological manifestations morphologically similar to eczema, psoriasis or dermatitis herpetiformis. This similarity was also confirmed histologically, but the immunopathological analysis showed the prevalence of deposits of C3 along the dermo-epidermal junction with a microgranular/granular pattern (82%).
conclusionsThe exact characterization of new clinical entities such as Cutaneous Gluten Sensitivity and NCGS is an important objective both for diagnostic and therapeutic purposes, since these are patients who actually benefit from a GFD (Gluten Free Diet) and who do not adopt it only for fashion.
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