Evidence map›Paper›PMID 26389939›Full record

ArticleViruses2015

High Rate of Simian Immunodeficiency Virus (SIV) Infections in Wild Chimpanzees in Northeastern Gabon.

Vanina Boué, Sabrina Locatelli, Floriane Boucher, Ahidjo Ayouba, Christelle Butel, Amandine Esteban, Alain-Prince Okouga, Alphonse Ndoungouet, Peggy Motsch, Guillaume Le Flohic and 5 more

Abstract read
In one paragraph

Article in Viruses, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
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  5. The HLA A03 Supertype and SeveralJournal of virology · 2020
    Article
  6. Article
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Vanina BouéUMI 233 "TransVIHMI", IRD / UM-INSERM U1175/ UM1, 34394 Montpellier, France. svetnina@yahoo.fr.
Sabrina LocatelliUMI 233 "TransVIHMI", IRD / UM-INSERM U1175/ UM1, 34394 Montpellier, France. sabrina.locatelli@ird.fr.
Floriane BoucherUMI 233 "TransVIHMI", IRD / UM-INSERM U1175/ UM1, 34394 Montpellier, France. floriane.boucher@wanadoo.fr.
Ahidjo AyoubaUMI 233 "TransVIHMI", IRD / UM-INSERM U1175/ UM1, 34394 Montpellier, France. ahidjo.ayouba@ird.fr.
Christelle ButelUMI 233 "TransVIHMI", IRD / UM-INSERM U1175/ UM1, 34394 Montpellier, France. christelle.butel@ird.fr.
Amandine EstebanUMI 233 "TransVIHMI", IRD / UM-INSERM U1175/ UM1, 34394 Montpellier, France. amandine.esteban@ird.fr.
Alain-Prince OkougaCentre International de Recherches Médicales, BP 769 Franceville, Gabon. aokouga@yahoo.com.
Alphonse NdoungouetCentre International de Recherches Médicales, BP 769 Franceville, Gabon. alphonsendoungouet@gmail.com.
Peggy MotschCentre International de Recherches Médicales, BP 769 Franceville, Gabon. p.motsch@yahoo.fr.
Guillaume Le FlohicCentre International de Recherches Médicales, BP 769 Franceville, Gabon. leflohg@yahoo.fr.
Paul NgariCentre International de Recherches Médicales, BP 769 Franceville, Gabon. paul_ngari@yahoo.fr.
Franck PrugnolleCentre International de Recherches Médicales, BP 769 Franceville, Gabon. franck.prugnolle@ird.fr.
Benjamin OllomoCentre International de Recherches Médicales, BP 769 Franceville, Gabon. bollomo@yahoo.fr.
François RouetCentre International de Recherches Médicales, BP 769 Franceville, Gabon. franrouet@yahoo.fr.
Florian LiégeoisUMI 233 "TransVIHMI", IRD / UM-INSERM U1175/ UM1, 34394 Montpellier, France. florian.liegeois@ird.fr.

Funding

Natural SIV Reservoirs and Human Zoonotic RiskR01AI050529 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HAHN, BEATRICE H · 2001 to 2022
$6.1M
NIAID NIH HHS R01 AI050529NIAID NIH HHS R01 AI 50529
6 · The paper itself

Abstract

The emergence of HIV-1 groups M, N, O, and P is the result of four independent cross-species transmissions between chimpanzees (cpz) and gorillas (gor) from central/south Cameroon and humans respectively. Although the first two SIVcpz were identified in wild-born captive chimpanzees in Gabon in 1989, no study has been conducted so far in wild chimpanzees in Gabon. To document the SIVcpz infection rate, genetic diversity, and routes of virus transmission, we analyzed 1458 faecal samples collected in 16 different locations across the country, and we conducted follow-up missions in two of them. We found 380 SIV antibody positive samples in 6 different locations in the north and northeast. We determined the number of individuals collected by microsatellite analysis and obtained an adjusted SIV prevalence of 39.45%. We performed parental analysis to investigate viral spread between and within communities and found that SIVs were epidemiologically linked and were transmitted by both horizontal and vertical routes. We amplified pol and gp41 fragments and obtained 57 new SIVcpzPtt strains from three sites. All strains, but one, clustered together within a specific phylogeographic clade. Given that these SIV positive samples have been collected nearby villages and that humans continue to encroach in ape's territories, the emergence of a new HIV in this area needs to be considered.

Indexed as

Pan troglodytesAnimalsAntibodies, ViralDisease Transmission, InfectiousFecesGabonGene Products, envGene Products, polMicrosatellite RepeatsMolecular EpidemiologyMolecular Sequence DataPrevalenceRNA, ViralSequence Analysis, DNASimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusAntibodies, ViralGene Products, envGene Products, polRNA, ViralAfricaAIDSantibodyChimpanzeemicrosatelliteprevalenceprimateretrovirusSIVtransmission

Identifiers

PMID26389939
PMCPMC4584299

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.