ArticleNature chemical biology2015
Two cytochromes P450 catalyze S-heterocyclizations in cabbage phytoalexin biosynthesis.
Article in Nature chemical biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 52 citations in OpenAlex.
- Metabolomic analysis of a core collection of Brassica rapa and Brassica oleracea unveils unexpected chemical diversity with potential applications in chemical ecology and breeding.BMC plant biology · 2026Article
- Mechanistic Perspective on C-N and C-S Bond Construction Catalyzed by Cytochrome P450 Enzymes.ACS bio & med chem Au · 2025Review
- Total Synthesis FacilitatesJournal of the American Chemical Society · 2024Article
- Article
- Comprehensive Analysis of Cytochrome P450 Monooxygenases Reveals Insight Into Their Role in Partial Resistance AgainstFrontiers in plant science · 2022Article
- BrCNGC gene family in field mustard: genome-wide identification, characterization, comparative synteny, evolution and expression profiling.Scientific reports · 2021Article
- One-pot enantioselective synthesis of (S)-spirobrassinin and non-natural (S)-methylspirobrassinin from amino acids using a turnip enzyme.Journal of natural medicines · 2021Article
- Engineering Plant Synthetic Pathways for the Biosynthesis of Novel Antifungals.ACS central science · 2020Article
- Atypical Myrosinase as a Mediator of Glucosinolate Functions in Plants.Frontiers in plant science · 2019Review
- DAIChE journal. American Institute of Chemical Engineers · 2018Article
- Oxidative Cyclization in Natural Product Biosynthesis.Chemical reviews · 2017Review
- Biosynthesis of cabbage phytoalexins from indole glucosinolate.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Bifunctional CYP81AA proteins catalyse identical hydroxylations but alternative regioselective phenol couplings in plant xanthone biosynthesis.Nature communications · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Phytoalexins are abundant in edible crucifers and have important biological activities, yet no dedicated gene for their biosynthesis is known. Here, we report two new cytochromes P450 from Brassica rapa (Chinese cabbage) that catalyze unprecedented S-heterocyclizations in cyclobrassinin and spirobrassinin biosynthesis. Our results provide genetic and biochemical insights into the biosynthesis of a prominent pair of dietary metabolites and have implications for pathway discovery across >20 recently sequenced crucifers.
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