ArticleJournal of molecular biology and molecular imaging
Transfer RNA as a source of small functional RNA.
Article in Journal of molecular biology and molecular imaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 55 citations in OpenAlex.
- Identification of tRNA-Derived Fragments in Legumes.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Mapping Current Studies of tRNA Fragments onto Disease Landscape.Biomolecules · 2025Review
- Influence of Maternal BLV Infection on miRNA and tRF Expression in Calves.Pathogens (Basel, Switzerland) · 2023Article
- tRNA-derived fragment tRF-1020 ameliorates diabetes-induced retinal microvascular complications.Journal of cellular and molecular medicine · 2022Article
- Long non-coding RNAs as the critical regulators of epithelial mesenchymal transition in colorectal tumor cells: an overview.Cancer cell international · 2022Review
- The production and secretion of tRNA-derived RNA fragments in the corn smut fungusFrontiers in fungal biology · 2022Article
- Differentially expressed tRNA-derived fragments in bovine fetuses with assisted reproduction induced congenital overgrowth syndrome.Frontiers in genetics · 2022Article
- LncRNAs are Involved in the Process of Atherosclerosis at Diverse Levels.Arquivos brasileiros de cardiologia · 2022Review
- The epitranscriptome of small non-coding RNAs.Non-coding RNA research · 2021Review
- MicroRNAs and Stem-like Properties: The Complex Regulation Underlying Stemness Maintenance and Cancer Development.Biomolecules · 2021Review
- Extensive profiling of the expressions of tRNAs and tRNA-derived fragments (tRFs) reveals the complexities of tRNA and tRF populations in plants.Science China. Life sciences · 2021Article
- Systemic alterations play a dominant role in epigenetic predisposition to breast cancer in offspring of obese fathers and is transmitted to a second generation.Scientific reports · 2021Article
- Integrated genomic analysis reveals regulatory pathways and dynamic landscapes of the tRNA transcriptome.Scientific reports · 2021Article
- Of rodents and ruminants: a comparison of small noncoding RNA requirements in mouse and bovine reproduction.Journal of animal science · 2021Article
- Small RNA sequencing reveals a novel tsRNA-06018 playing an important role during adipogenic differentiation of hMSCs.Journal of cellular and molecular medicine · 2020Article
- A novel tsRNA-16902 regulating the adipogenic differentiation of human bone marrow mesenchymal stem cells.Stem cell research & therapy · 2020Article
- Inferring targeting modes of Argonaute-loaded tRNA fragments.RNA biology · 2020Article
- Oxidative stress enhances the expression of 2',3'-cyclic phosphate-containing RNAs.RNA biology · 2020Article
- Human sperm displays rapid responses to diet.PLoS biology · 2019Article
- Genome-wide identification of short 2',3'-cyclic phosphate-containing RNAs and their regulation in aging.PLoS genetics · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Since their discovery in the 1950s, transfer RNAs (tRNAs) have been best known as adapter molecules that play a central role in translating genetic information. However, recent biochemical and bioinformatic evidence has led to a previously unexpected conceptual consensus that tRNAs are not always end products; they further serve as a source of small functional RNAs. In many organisms, specific tRNA fragments are produced from mature tRNAs or their precursor transcripts not as random degradation products, but as functional molecules involved in many biological processes beyond translation. In this review, we summarize recent studies of tRNA fragments that have provided new insights into tRNA biology by examining the molecular functions of tRNA fragments and proteins with which they interact.
Indexed as
Identifiers
26389128PMC4572697W2461322896What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.