ReviewFrontiers in cell and developmental biology2015
Developing a functional urinary bladder: a neuronal context.
Review in Frontiers in cell and developmental biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Transcriptome profiling suggests molecular sexual dimorphism in lumbosacral dorsal root ganglia and sex-specific mechanisms underlying visceral pain.Physiological genomics · 2026Article
- 3D Printing for Neural Repair: Bridging the Gap in Regenerative Medicine.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Genetic tools that target mechanoreceptors produce reliable labeling of bladder afferents and altered mechanosensation.American journal of physiology. Renal physiology · 2025Article
- HumaneLife · 2024Article
- Innervation pattern of the unclosed detrusor muscle in classic bladder exstrophy: a study of patients with urothelial overexpression of nerve growth factor.Pediatric surgery international · 2024Article
- Neurogenic Defects Occur inKidney international reports · 2023Article
- Pharmacogenetic inhibition of lumbosacral sensory neurons alleviates visceral hypersensitivity in a mouse model of chronic pelvic pain.PloS one · 2022Article
- Expanding theFrontiers in genetics · 2022Article
- Spatiotemporal mapping of sensory and motor innervation of the embryonic and postnatal mouse urinary bladder.Developmental biology · 2021Article
- Mapping the peripheral nervous system in the whole mouse via compressed sensing tractography.Journal of neural engineering · 2021Article
- Paracervical ganglion in the female pig during prenatal development: Morphology and immunohistochemical characteristics.Histology and histopathology · 2020Article
- Dissection of Pelvic Autonomic Ganglia and Associated Nerves in Male and Female Rats.Journal of visualized experiments : JoVE · 2020Article
- A homozygous missense variant in CHRM3 associated with familial urinary bladder disease.Clinical genetics · 2019Article
- Innervation of internal female genital organs in the pig during prenatal development.Journal of anatomy · 2019Article
- A temporal and spatial map of axons in developing mouse prostate.Histochemistry and cell biology · 2019Article
- Lrig2 and Hpse2, mutated in urofacial syndrome, pattern nerves in the urinary bladder.Kidney international · 2019Article
- Electroceutical Targeting of the Autonomic Nervous System.Physiology (Bethesda, Md.) · 2019Article
- Serotonin Receptor 5-HT3A Affects Development of Bladder Innervation and Urinary Bladder Function.Frontiers in neuroscience · 2017Article
- PACAP/Receptor System in Urinary Bladder Dysfunction and Pelvic Pain Following Urinary Bladder Inflammation or Stress.Frontiers in systems neuroscience · 2017Review
- Accelerated onset of the vesicovesical reflex in postnatal NGF-OE mice and the role of neuropeptides.Experimental neurology · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The development of organs occurs in parallel with the formation of their nerve supply. The innervation of pelvic organs (lower urinary tract, hindgut, and sexual organs) is complex and we know remarkably little about the mechanisms that form these neural pathways. The goal of this short review is to use the urinary bladder as an example to stimulate interest in this question. The bladder requires a healthy mature nervous system to store urine and release it at behaviorally appropriate times. Understanding the mechanisms underlying the construction of these neural circuits is not only relevant to defining the basis of developmental problems but may also suggest strategies to restore connectivity and function following injury or disease in adults. The bladder nerve supply comprises multiple classes of sensory, and parasympathetic or sympathetic autonomic effector (motor) neurons. First, we define the developmental endpoint by describing this circuitry in adult rodents. Next we discuss the innervation of the developing bladder, identifying challenges posed by this area of research. Last we provide examples of genetically modified mice with bladder dysfunction and suggest potential neural contributors to this state.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.