Evidence map›Paper›PMID 26389003›Full record

ArticleJournal of pharmacopuncture2015

Taurine Regulates Mitochondrial Function During 7,12-Dimethyl Benz[a]anthracene Induced Experimental Mammary Carcinogenesis.

Manickam Kalappan Vanitha, Kalpana Deepa Priya, Kuppusamy Baskaran, Kuppusamy Periyasamy, Dhravidamani Saravanan, Ramachandran Venkateswari, Balasundaram Revathi Mani, Aruldass Ilakkia, Sundaramoorthy Selvaraj, Rajendran Menaka and 4 more

Abstract read
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In one paragraph

Article in Journal of pharmacopuncture, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Clinical implications of taurine in breast cancer.Biochemistry and biophysics reports · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Manickam Kalappan VanithaDepartment of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India.
Kalpana Deepa PriyaDepartment of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India.
Kuppusamy BaskaranDepartment of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India.
Kuppusamy PeriyasamyDepartment of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India.
Dhravidamani SaravananDepartment of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India.
Ramachandran VenkateswariDepartment of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India.
Balasundaram Revathi ManiDepartment of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India.
Aruldass IlakkiaDepartment of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India.
Sundaramoorthy SelvarajDepartment of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India.
Rajendran MenakaDepartment of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India.
Mahendran GeethaDepartment of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India.
Nadarajah RashanthyDepartment of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India.
Pandi AnandakumarDepartment of Biomedical Sciences, College of Health Sciences, Arsi University, Asella, Ethiopia.
Dhanapal SakthisekaranDepartment of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe present study was undertaken to determine the modulatory effect of taurine on the liver mitochondrial enzyme system with reference to mitochondrial lipid peroxidation (LPO), antioxidants, major tricarboxylic acid cycle enzymes, and electron transport chain enzymes during 7,12-dimethyl benz[a]anthracene (DMBA) induced breast cancer in Sprague-Dawley rats.

methodsAnimals in which breast cancer had been induced by using DMBA (25 mg/kg body weight) showed an increase in mitochondrial LPO together with decreases in enzymic antioxidants (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione-S-transferase (GST)), non-enzymic antioxidants (reduced glutathione (GSH), vitamin C, and vitamin E), in citric acid cycle enzymes (isocitrate dehydrogenase (ICDH), alpha ketoglutarate dehydrogenase (alpha KDH), succinate dehydrogenase (SDH) and malate dehydrogenase (MDH)), and in electron transport chain (ETC) complexes.

resultsTaurine (100 mg/kg body weight) treatment decreased liver mitochondrial LPO and augmented the activities/levels of enzymic, and non-enzymic antioxidants, tricarboxylic acid cycle enzymes and ETC complexes.

conclusionThe results of our present study demonstrated the chemotherapeutic efficacy of taurine treatment for DMBA-induced breast carcinomas.

Indexed as

breast cancerelectron transport chain complexesmitochondrial antioxidantmitochondrial lipid peroxidationtaurinetricarboxylic acid cycle enzymes

Identifiers

PMID26389003
PMCPMC4573810

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.