ArticleFrontiers in plant science2015
Analysis of global gene expression profile of rice in response to methylglyoxal indicates its possible role as a stress signal molecule.
Article in Frontiers in plant science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 75 citations in OpenAlex.
- Article
- Effect of citrulline seed priming on growth, photosynthesis, redox equilibrium, secondary metabolic enzymes, metal sequestration and nutrient acquisition in sunflower (Helianthus annuus L.) under chromium toxicity.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Tracing the intraspecies expansion of glyoxalase genes and their expanding roles across the genus Oryza.Functional & integrative genomics · 2024Article
- Role of methylglyoxal and glyoxalase in the regulation of plant response to heavy metal stress.Plant cell reports · 2024Review
- Article
- Roles of Reactive Carbonyl Species (RCS) in Plant Response to Abiotic Stress.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Elevated methylglyoxal levels inhibit tomato fruit ripening by preventing ethylene biosynthesis.Plant physiology · 2023Article
- Glyoxalase I activity affects Arabidopsis sensitivity to ammonium nutrition.Plant cell reports · 2022Article
- De Novo Transcriptome ofPlants (Basel, Switzerland) · 2022Article
- Methylglyoxal-glyoxalase system as a possible selection module for raising marker-safe plants in rice.Physiology and molecular biology of plants : an international journal of functional plant biology · 2021Article
- Glutathione Metabolism in Plants under Stress: Beyond Reactive Oxygen Species Detoxification.Metabolites · 2021Review
- The metabolite methylglyoxal-mediated gene expression is associated with histone methylglyoxalation.Nucleic acids research · 2021Article
- Comparative transcriptome analysis of Rheum australe, an endangered medicinal herb, growing in its natural habitat and those grown in controlled growth chambers.Scientific reports · 2021Article
- Interplay among Oxidative Stress, Methylglyoxal Pathway and S-Glutathionylation.Antioxidants (Basel, Switzerland) · 2020Review
- Genetic analysis of rice seedling traits related to machine transplanting under different seeding densities.BMC genetics · 2020Article
- Functional characterization of the Glyoxalase-I (Plant signaling & behavior · 2020Article
- Quantification of Methylglyoxal Levels in Cowpea Leaves in Response to Cowpea Aphid Infestation.Bio-protocol · 2020Article
- Plant anti-aging: Delayed flower and leaf senescence inPlant signaling & behavior · 2020Article
- From methylglyoxal to pyruvate: a genome-wide study for the identification of glyoxalases and D-lactate dehydrogenases in Sorghum bicolor.BMC genomics · 2020Article
- Transcriptomic data-driven discovery of global regulatory features of rice seeds developing under heat stress.Computational and structural biotechnology journal · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Methylglyoxal (MG) is a toxic metabolite produced primarily as a byproduct of glycolysis. Being a potent glycating agent, it can readily bind macromolecules like DNA, RNA, or proteins, modulating their expression and activity. In plants, despite the known inhibitory effects of MG on growth and development, still limited information is available about the molecular mechanisms and response pathways elicited upon elevation in MG levels. To gain insight into the molecular basis of MG response, we have investigated changes in global gene expression profiles in rice upon exposure to exogenous MG using GeneChip microarrays. Initially, growth of rice seedlings was monitored in response to increasing MG concentrations which could retard plant growth in a dose-dependent manner. Upon exposure to 10 mM concentration of MG, a total of 1685 probe sets were up- or down-regulated by more than 1.5-fold in shoot tissues within 16 h. These were classified into 10 functional categories. The genes involved in signal transduction such as, protein kinases and transcription factors, were significantly over-represented in the perturbed transcriptome, of which several are known to be involved in abiotic and biotic stress response indicating a cross-talk between MG-responsive and stress-responsive signal transduction pathways. Through in silico studies, we could predict 7-8 bp long conserved motif as a possible MG-responsive element (MGRE) in the 1 kb upstream region of genes that were more than 10-fold up- or down-regulated in the analysis. Since several perturbations were found in signaling cascades in response to MG, we hereby suggest that it plays an important role in signal transduction probably acting as a stress signal molecule.
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