ReviewFrontiers in psychology2015
Impulsive delayed reward discounting as a genetically-influenced target for drug abuse prevention: a critical evaluation.
Review in Frontiers in psychology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 5 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Effects of different exercise types on craving in substance use disorder patients with drug dependence -network meta-analysis and dose-response relationships based on frequentist and Bayesian models.Addiction science & clinical practice · 2025Pooled it
- A systematic review and meta-analysis of test-retest reliability and stability of delay and probability discounting.Journal of the experimental analysis of behavior · 2024Pooled it
- A systematic review and meta-analysis of delay discounting and cannabis use.Experimental and clinical psychopharmacology · 2021Pooled it
- Behavioral trainings and manipulations to reduce delay discounting: A systematic review.Psychonomic bulletin & review · 2019Pooled it
- Experimental reductions of delay discounting and impulsive choice: A systematic review and meta-analysis.Journal of experimental psychology. General · 2018Pooled it
- Genetically influenced externalizing and internalizing risk pathways as novel prevention targets.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2022Trial
- Trial
- Associations Between Steep Delay Discounting and Punishment Learning.Computational psychiatry (Cambridge, Mass.) · 2026Article
- Genetic Propensity for Delay Discounting and Educational Attainment in Adults Are Associated With Delay Discounting in Preadolescents: Findings From the Adolescent Brain Cognitive Development Study.Genes, brain, and behavior · 2025Article
- Previous experience of action-effect predictability and delay affect perceived agency and decision-making independently.Experimental brain research · 2024Article
- Increased white blood cell in young adults with family histories of alcohol and other substance use disorders.Addiction biology · 2024Article
- Spontaneous neural activity in the three principal networks underlying delay discounting: a resting-state fMRI study.Frontiers in psychiatry · 2024Article
- Psychedelic therapy in the treatment of addiction: the past, present and future.Frontiers in psychiatry · 2023Review
- The problems with delay discounting: a critical review of current practices and clinical applications.Psychological medicine · 2021Review
- Reducing impulsive choice VII: effects of duration of delay-exposure training.Animal cognition · 2021Article
- Heroin delay discounting and impulsivity: Modulation by DRD1 genetic variation.Addiction biology · 2020Article
- Reducing impulsive choice: VI. Delay-exposure training reduces aversion to delay-signaling stimuli.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2020Article
- Excessive discounting of delayed reinforcers as a trans-disease process: Update on the state of the science.Current opinion in psychology · 2019Review
- Demand characteristics in episodic future thinking II: The role of cues and cue content in changing delay discounting.Experimental and clinical psychopharmacology · 2019Article
- Repeated administration of synthetic cathinone 3,4-methylenedioxypyrovalerone persistently increases impulsive choice in rats.Behavioural pharmacology · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
This review evaluates the viability of delayed reward discounting (DRD), an index of how much an individual devalues a future reward based on its delay in time, for genetically-informed drug abuse prevention. A review of the literature suggests that impulsive DRD is robustly associated with drug addiction and meets most of the criteria for being an endophenotype, albeit with mixed findings for specific molecular genetic influences. Several modes of experimental manipulation have been demonstrated to reduce DRD acutely. These include behavioral strategies, such as mindfulness, reward bundling, and episodic future thinking; pharmacological interventions, including noradrenergic agonists, adrenergic agonists, and multiple monoamine agonists; and neuromodulatory interventions, such as transcranial magnetic stimulation and transcranial direct current stimulation. However, the generalization of these interventions to positive clinical outcomes remains unclear and no studies to date have examined interventions on DRD in the context of prevention. Collectively, these findings suggest it would be premature to target DRD for genetically-informed prevention. Indeed, given the evidence of environmental contributions to impulsive DRD, whether genetically-informed secondary prevention would ever be warranted is debatable. Progress in identifying polymorphisms associated with DRD profiles could further clarify the underlying biological systems for pharmacological and neuromodulatory interventions, and, as a qualitatively different risk factor from existing prevention programs, impulsive DRD is worthy of investigation at a more general level as a novel and promising drug abuse prevention target.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.