Evidence map›Paper›PMID 26388727›Full record

ArticleFrontiers in molecular neuroscience2015

Cell biological mechanisms of activity-dependent synapse to nucleus translocation of CRTC1 in neurons.

Toh Hean Ch'ng, Martina DeSalvo, Peter Lin, Ajay Vashisht, James A Wohlschlegel, Kelsey C Martin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Article
  3. S-Nitrosylation of CRTC1 in Alzheimer's disease impairs CREB-dependent gene expression induced by neuronal activity.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Experience-Regulated Neuronal Signaling in Maternal Behavior.Frontiers in molecular neuroscience · 2022
    Review
  8. Article
  9. CaeLife · 2021
    Article
  10. Article
  11. Article
  12. Article
  13. Article
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  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Toh Hean Ch'ngLee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore ; School of Biological Sciences, Nanyang Technological University Singapore, Singapore.
Martina DeSalvoDepartment of Biological Chemistry, University of California, Los Angeles Los Angeles, CA, USA.
Peter LinDepartment of Neurology and Neuroscience, Stanford University Palo Alto, CA, USA.
Ajay VashishtDepartment of Biological Chemistry, University of California, Los Angeles Los Angeles, CA, USA.
James A WohlschlegelDepartment of Biological Chemistry, University of California, Los Angeles Los Angeles, CA, USA.
Kelsey C MartinDepartment of Biological Chemistry, University of California, Los Angeles Los Angeles, CA, USA ; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles Los Angeles, CA, USA.
University of California, Los Angeles · USNanyang Technological University · SGNeurobehavioral Systems · USStanford University · US

Funding

Proteolytic Control of Iron Metabolism by the Ubiquitin Ligase FBXL5R01GM089778 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WOHLSCHLEGEL, JAMES AKIRA · 2010 to 2023
$4.0M
Synapse to Nuclear Signaling During Long-Lasting Neuronal PlasticityR01MH077022 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARTIN, KELSEY C · 2007 to 2017
$3.1M
NIGMS NIH HHS R01 GM089778NIMH NIH HHS R01 MH077022
6 · The paper itself

Abstract

Previous studies have revealed a critical role for CREB-regulated transcriptional coactivator (CRTC1) in regulating neuronal gene expression during learning and memory. CRTC1 localizes to synapses but undergoes activity-dependent nuclear translocation to regulate the transcription of CREB target genes. Here we investigate the long-distance retrograde transport of CRTC1 in hippocampal neurons. We show that local elevations in calcium, triggered by activation of glutamate receptors and L-type voltage-gated calcium channels, initiate active, dynein-mediated retrograde transport of CRTC1 along microtubules. We identify a nuclear localization signal within CRTC1, and characterize three conserved serine residues whose dephosphorylation is required for nuclear import. Domain analysis reveals that the amino-terminal third of CRTC1 contains all of the signals required for regulated nucleocytoplasmic trafficking. We fuse this region to Dendra2 to generate a reporter construct and perform live-cell imaging coupled with local uncaging of glutamate and photoconversion to characterize the dynamics of stimulus-induced retrograde transport and nuclear accumulation.

Indexed as

active transportCREBCRTC1learning and memorysynapse to nucleus signalingsynaptic plasticitytranscription-dependent plasticity

Identifiers

PMID26388727
PMCPMC4560099
OpenAlexW1942500941

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.