ArticleCancer cell international2015
Dysregulated miR-645 affects the proliferation and invasion of head and neck cancer cell.
Article in Cancer cell international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- An efficient and interactive feature selection approach based on copula entropy for high-dimensional genetic data.Scientific reports · 2025Article
- Circulating Extracellular-Vesicle-Incorporated MicroRNAs as Potential Biomarkers for Ischemic Stroke in Patients With Cancer.Journal of stroke · 2023Article
- CircFAM120B Blocks the Development of Colorectal Cancer by Activating TGF-Beta Receptor II Expression via Targeting miR-645.Frontiers in cell and developmental biology · 2021Article
- Down-Regulation ofFrontiers in oncology · 2020Article
- Article
- Differentially Expressed mRNA Targets of Differentially Expressed miRNAs Predict Changes in the TP53 Axis and Carcinogenesis-Related Pathways in Human Keratinocytes Chronically Exposed to Arsenic.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
- MicroRNA-645 is an oncogenic regulator in colon cancer.Oncogenesis · 2017Article
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Authors and funding
11 authors.
Funding
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Abstract
background and purposeDysregulated miRNAs play an important role in many malignant tumors. However, elucidating the roles of miRNAs in cancer biology, especially in epithelial cancers, remains an ongoing process. In this study, we identified the differentially expressed miR-645 in the progressing of head and neck squamous cell carcinoma (HNSCC) and investigated its biological function.
methodsThe association between clinicopathological parameters and the expression levels of the candidated miRNAs were analyzed by using the Kaplan-Meier survival analysis. The cell growth, invasion and migration potential, and clone formation were observed to detect the functions of the miRNAs in HNSCC cells.
resultsIn the 34 HNSCC tissues with lymph node metastasis, the expression level of miR-645 was 0.54 ± 0.12, and the expression level was 0.22 ± 0.05 in the 28 tissues with non lymph node metastasis (p = 0.017). In patients with HNSCC, higher level of miR-645 expression significantly correlates with worse overall survival (p = 0.04). Ectopic expression of miR-645 promoted cell invasion and migration.
conclusionsmiR-645 play a key role in cell invasion and metastasis and their expression correlates with overall survival in the patients with HNSCC.
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