ArticleDrug design, development and therapy2015
Pentoxifylline and electromagnetic field improved bone fracture healing in rats.
Article in Drug design, development and therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Phosphodiesterase inhibitors as emerging therapeutics for skeletal disorders: A comprehensive review of mechanisms and repurposing potential.Bone reports · 2026Review
- The role of electrical stimulation in bone regeneration: mechanistic insights and therapeutic advances.Bioelectronic medicine · 2025Review
- Non-contact electrical stimulation via a Vector-potential transformer promotes bone healing in drill-hole injury model.Journal of bone and mineral metabolism · 2025Article
- Thermodynamic Considerations on the Biophysical Interaction between Low-Energy Electromagnetic Fields and Biosystems.Membranes · 2024Article
- Gathering Evidence to Leverage Musculoskeletal Magnetic Stimulation Towards Clinical Applicability.Small science · 2024Article
- Signalling pathways underlying pulsed electromagnetic fields in bone repair.Frontiers in bioengineering and biotechnology · 2024Review
- Comparative effects of systemic administration of levofloxacin and cephalexin on fracture healing in rats.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2022Article
- Electrical Stimulation of Acute Fractures: A Narrative Review of Stimulation Protocols and Device Specifications.Frontiers in bioengineering and biotechnology · 2022Review
- Electronic Bone Growth Stimulators for Augmentation of Osteogenesis inFrontiers in bioengineering and biotechnology · 2022Review
- Long-term Interactions of Circulating Neutrophils with Titanium Implants, the Role of Platelets in Regulation of Leukocyte Function.International journal of molecular sciences · 2021Article
- Electrical stimulation-based bone fracture treatment, if it works so well why do not more surgeons use it?European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2020Review
- [Effect of low-frequency pulsed electromagnetic fields on activity of rat calvarial osteoblasts through IGF-1R/NO signaling pathway].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2019Article
- Emerging medical applications based on non-ionizing electromagnetic fields from 0 Hz to 10 THz.Medical devices (Auckland, N.Z.) · 2019Article
- Effects of pentoxifylline and alendronate on fracture healing in ovariectomy-induced osteoporosis in rats.Veterinary research forum : an international quarterly journal · 2019Article
- Extremely low frequency electromagnetic fields promote mesenchymal stem cell migration by increasing intracellular CaStem cell research & therapy · 2018Article
- The effects of pentoxifylline adminstration on fracture healing in a postmenopausal osteoporotic rat model.Laboratory animal research · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to evaluate the effects of a phosphodiesterase inhibitor pentoxifylline (PTX), electromagnetic fields (EMFs), and a mixture of both materials on bone fracture healing in a rat model. MATERIALS AND
methodsEighty male Wistar rats were randomly divided into four groups: Group A, femur fracture model with no treatment; Group B, femur fracture model treated with PTX 50 mg/kg/day intraperitoneal injection; Group C, femur fracture model treated with EMF 1.5±0.2 Mt/50 Hz/6 hours/day; and Group D, femur fracture model treated with PTX 50 mg/kg/day intraperitoneal injection and EMF 1.5±0.2 Mt/50 Hz/6 hours/day.
resultsBone fracture healing was significantly better in Group B and Group C compared to Group A (P<0.05), but Group D did not show better bone fracture healing than Group A (P>0.05).
conclusionIt can be concluded that both a specific EMF and PTX had a positive effect on bone fracture healing but when used in combination, may not be beneficial.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.