Evidence map›Paper›PMID 26388521›Full record

ArticleBone2015

Non-contact strain measurement in the mouse forearm loading model using digital image correlation (DIC).

Mark T Begonia, Mark Dallas, Bruno Vizcarra, Ying Liu, Mark L Johnson, Ganesh Thiagarajan

Abstract read
In one paragraph

Article in Bone, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Biomechanical coupling facilitates spinal neural tube closure in mouse embryos.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mark T BegoniaUniversity of Missouri-Kansas City, Department of Civil and Mechanical Engineering, 350K Robert H. Flarsheim Hall, 5110 Rockhill Road, Kansas City, MO 64110, USA.
Mark DallasUniversity of Missouri-Kansas City, School of Dentistry, Department of Oral and Craniofacial Sciences, Room 3143, 650 E 25th Street, Kansas City, MO 64108, USA.
Bruno VizcarraUniversity of Missouri-Kansas City, Department of Civil and Mechanical Engineering, 350K Robert H. Flarsheim Hall, 5110 Rockhill Road, Kansas City, MO 64110, USA.
Ying LiuUniversity of Missouri-Kansas City, School of Dentistry, Department of Oral and Craniofacial Sciences, Room 3143, 650 E 25th Street, Kansas City, MO 64108, USA.
Mark L JohnsonUniversity of Missouri-Kansas City, School of Dentistry, Department of Oral and Craniofacial Sciences, Room 3143, 650 E 25th Street, Kansas City, MO 64108, USA.
Ganesh ThiagarajanUniversity of Missouri-Kansas City, Department of Civil and Mechanical Engineering, 350K Robert H. Flarsheim Hall, 5110 Rockhill Road, Kansas City, MO 64110, USA. Electronic address: ganesht@umkc.edu.

Funding

Transgenic and Mechanical Loading CoreP01AG039355 · NIA · UNIVERSITY OF MISSOURI KANSAS CITY · PI BONEWALD, LYNDA F · 2012 to 2024
$19.3M
THE ROLE OF LRP5 IN BONE RESPONSE TO MECHANICAL LOADINGR01AR053949 · NIAMS · UNIVERSITY OF MISSOURI KANSAS CITY · PI JOHNSON, MARK LOUIS · 2007 to 2011
$1.6M
NIAMS NIH HHS R01 AR053949NIA NIH HHS P01 AG039355
6 · The paper itself

Abstract

This study investigates the use of a non-contact method known as digital image correlation (DIC) to measure strains in the mouse forearm during axial compressive loading. A two camera system was adapted to analyze the medial and lateral forearm displacements simultaneously, and the derived DIC strain measurements were compared to strain gage readings from both the ulna and radius. Factors such as region-of-interest (ROI) location, lens magnification, noise, and out-of-plane motion were examined to determine their influence on the DIC strain measurements. We confirmed that our DIC system can differentiate ROI locations since it detected higher average strains in the ulna compared to the radius and detected compressive strains on medial bone surfaces vs. tensile strains on lateral bone surfaces. Interestingly, the DIC method also captured heterogeneity in surface strain fields which are not detectable by strain gage based methods. A separate analysis of the noise intrinsic to the DIC system also revealed that the noise constituted less than 4.5% of all DIC strain measurements. Furthermore, finite element (FE) simulations of the forearm showed that out-of-plane motion was not a significant factor that influenced DIC measurements. Finally, we observed that average DIC strain measurements can be up to 1.5-2 times greater than average strain gage readings on the medial bone surfaces. These findings suggest that strain experienced in the mouse forearm model by loading is better captured through DIC as opposed to strain gages, which as a result of being glued to the bone surface artificially stiffen the bone and lead to an underestimation of the strain response.

Indexed as

AnimalsBiomechanical PhenomenaBone and BonesExtremitiesFemaleImage Processing, Computer-AssistedMiceMice, Inbred C57BLStress, MechanicalTibiaUlnaWeight-BearingDigital image correlationForearmRadiusStrainUlna

Identifiers

PMID26388521
PMCPMC4640949

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.