ArticleJournal of the American Chemical Society2015
Stimuli-Responsive Polymer Film that Autonomously Translates a Molecular Detection Event into a Macroscopic Change in Its Optical Properties via a Continuous, Thiol-Mediated Self-Propagating Reaction.
Article in Journal of the American Chemical Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Naked-Eye Thiol Analyte Detection via Self-Propagating, Amplified Reaction Cycle.Journal of the American Chemical Society · 2023Article
- Small-molecule fluorescent probes based on covalent assembly strategy for chemoselective bioimaging.RSC advances · 2022Review
- Recent Progress on Molecular Photoacoustic Imaging with Carbon-Based Nanocomposites.Materials (Basel, Switzerland) · 2021Review
- Base-triggered self-amplifying degradable polyurethanes with the ability to translate local stimulation to continuous long-range degradation.Chemical science · 2020Article
- Recent Progress on Near-Infrared Photoacoustic Imaging: Imaging Modality and Organic Semiconducting Agents.Polymers · 2019Review
- Self-Propagating Amplification Reactions for Molecular Detection and Signal Amplification: Advantages, Pitfalls, and Challenges.Journal of physical organic chemistry · 2018Article
- Chemical Design of Functional Polymer Structures for Biosensors: From Nanoscale to Macroscale.Polymers · 2018Review
- Probing the causes of thermal hysteresis using tunablePolymer chemistry · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
This Communication describes a chemically responsive polymer film that is capable of detecting low levels of a specific applied molecular signal (thiol) and subsequently initiating a self-propagating reaction within the material that converts the nonfluorescent film into a globally fluorescent material. We illustrate that the intensity of the resulting fluorescent material is independent of the quantity of the applied thiol, whereas the rate to reach the maximum level of signal is directly proportional to the quantity of the signal. In contrast, a control film, which lacks functionality for mediating the self-propagating reaction, provides a maximum change in fluorescence that is directly proportional to the quantity of the applied thiol. This level of nonamplified signal is 78% lower in intensity (when initiated with 100 μM of applied thiol) than is achieved when the material contains functionality that supports the self-powered, self-propagating amplification reaction.
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Registered trials
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