ArticleRespiratory physiology & neurobiology2016
Quantifying the shape of maximal expiratory flow-volume curves in healthy humans and asthmatic patients.
Article in Respiratory physiology & neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Exercise-induced bronchodilation is not impacted by beta-adrenergic receptor blockade in males or females.European journal of applied physiology · 2026Trial
- Lung function decline after mountain ultra-marathon is accompanied by reduced inspiratory pressure but not by detectable changes in CC16.European journal of applied physiology · 2026Article
- Distal Airway Inflammation Is Linked to Small Airway Dysfunction in Asthma.Medical sciences (Basel, Switzerland) · 2026Observational
- Assessing the repeatability of expiratory flow limitation during incremental exercise in healthy adults.Physiological reports · 2024Article
- Effect of exercise-induced bronchoconstriction on the configuration of the maximal expiratory flow-volume curve in adults with asthma.Physiological reports · 2023Article
- Sex, gender and the pulmonary physiology of exercise.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Application of Machine Learning in Pulmonary Function Assessment Where Are We Now and Where Are We Going?Frontiers in physiology · 2021Article
- Analysis of maximal expiratory flow-volume curves in adult survivors of preterm birth.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Spirometric and exercise ventilatory predictors of expiratory flow-limitation in adults with normal and mildly-obstructed airways.Respiratory physiology & neurobiologyArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Differences in the absolute flow and volume of maximal expiratory flow-volume (MEFV) curves have been studied extensively in health and disease. However, the shapes of MEFV curves have received less attention. We questioned if the MEFV curve shape was associated with (i) expiratory flow limitation (EFL) in health and (ii) changes in bronchial caliber in asthmatics. Using the slope-ratio (SR) index, we quantified MEFV curve shape in 84 healthy subjects and 8 matched asthmatics. Healthy subjects performed a maximal exercise test to assess EFL. Those with EFL during had a greater SR (1.15 ± 0.20 vs. 0.85 ± 0.20, p<0.05) yet, there was no association between maximal oxygen consumption and SR (r=0.14, p>0.05). Asthmatics average SR was greater than the healthy subjects (1.35 ± 0.03 vs. 0.90 ± 0.11, p<0.05), but there were no differences when bronchial caliber was manipulated. In conclusion, a greater SR is related to EFL and this metric could aid in discriminating between groups known to differ in the absolute size of MEFV curves.
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Registered trials
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