ReviewHormones and behavior2016
Long-term alterations in neural and endocrine processes induced by motherhood in mammals.
Review in Hormones and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Toxic Effects of Glyphosate on the Nervous System: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Article
- Reproductive experience modifies the dopaminergic system of postpartum estrous rats: changes in the sensitivity to the behavioural effects of sch-23390 and in its receptors' binding.Psychopharmacology · 2026Article
- Microstructural alterations in brain tissue of ME/CFS and long COVID using diffusion tensor imaging and diffusion kurtosis imaging.Frontiers in medicine · 2026Article
- Multiparity alters expression of corticotropin releasing factor receptor 1 and co-expression with oxytocin neurons in mice.Hormones and behavior · 2025Article
- Litter sex composition influences plasma prolactin levels but not the melanin-concentrating hormone immunoreactive neurons in the medial preoptic area of late lactating Long-Evans rats.Journal of neuroendocrinology · 2025Article
- Immediate Skin-to-Skin Contact at Very Preterm Birth and Neurodevelopment the First Two Years: Secondary Outcomes from a Randomised Clinical Trial.Children (Basel, Switzerland) · 2025Article
- Altered thermal preference by preoptic estrogen receptor alpha neurons in postpartum females.Molecular metabolism · 2025Article
- Experience and trust: the benefits of mate familiarity are realized through sex-specific specialization of parental roles in Cassin's auklet.Royal Society open science · 2024Article
- Mother-Offspring Bonding after Calving in Water Buffalo and Other Ruminants: Sensory Pathways and Neuroendocrine Aspects.Animals : an open access journal from MDPI · 2024Review
- Re-wiring of the bonded brain: Gene expression among pair bonded female prairie voles changes as they transition to motherhood.Genes, brain, and behavior · 2024Article
- Environmental enrichment attenuates depressive-like behavior in maternal rats by inhibiting neuroinflammation and apoptosis and promoting neuroplasticity.Neurobiology of stress · 2024Article
- Roadmap for maternal behavior research in domestic dogs: lessons from decades of laboratory rodent work.Frontiers in veterinary science · 2024Review
- Oxytocin receptors in the nucleus accumbens shell are necessary for the onset of maternal behavior.Frontiers in neuroscience · 2024Article
- Parental experience is linked with lower vasopressin receptor 1a binding and decreased postpartum androgens in titi monkeys.Journal of neuroendocrinology · 2023Article
- The Role of Oxytocin in Domestic Animal's Maternal Care: Parturition, Bonding, and Lactation.Animals : an open access journal from MDPI · 2023Review
- Hearing Vocalizations during First Social Experience with Pups Increase Bdnf Transcription in Mouse Auditory Cortex.Neural plasticity · 2023Article
- What can challenging reproductive contexts tell us about the rat's maternal behavior?Frontiers in behavioral neuroscience · 2023Article
- Article
- Long-term association of pregnancy and maternal brain structure: the Rotterdam Study.European journal of epidemiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
This article is part of a Special Issue "Parental Care". The reproductive experience of pregnancy, lactation and motherhood can significantly remodel the female's biological state, affecting endocrine, neuroendocrine, neural, and immunological processes. The brain, pituitary gland, liver, thymus, and mammary tissue are among the structures that are modified by reproductive experience. The present review that focuses on rodent research, but also includes pertinent studies in sheep and other species, identifies specific changes in these processes brought about by the biological states of pregnancy, parturition, and lactation and how the components of reproductive experience contribute to the remodeling of the maternal brain and organ systems. Findings indicate that prior parity alters key circulating hormone levels and neural receptor gene expression. Moreover, reproductive experience results in modifications in neural processes and glial support. The possible role of pregnancy-induced neurogenesis is considered in the context of neuroplasticity and behavior, and the effects of reproductive experience on maternal memory, i.e. the retention of maternal behavior, together with anxiety and learning are presented. Together, these sets of findings support the concept that the neural and biological state of the adult female is significantly and dramatically altered on a long-term basis by the experiences of parity and motherhood. Remodeling of the maternal brain and other biological systems is posited to help facilitate adaptations to environmental/ecological challenges as the female raises young and ages.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.