ArticleJournal of shoulder and elbow surgery2016
Rotator cuff repair augmentation in a rat model that combines a multilayer xenograft tendon scaffold with bone marrow stromal cells.
Article in Journal of shoulder and elbow surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 58 citations in OpenAlex.
- [Key role of biomechanical properties and material selection in rotator cuff repair].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025Review
- Efficacy of hyaluronic acid and conditioned serum in acute rotator cuff tear repair: A rat model study.Acta orthopaedica et traumatologica turcica · 2025Article
- Regenerative properties of bone marrow mesenchymal stem cell derived exosomes in rotator cuff tears.Journal of translational medicine · 2025Review
- Scaffold-based tissue engineering strategies for soft-hard interface regeneration.Regenerative biomaterials · 2023Review
- Evaluation of patches for rotator cuff repair: A systematic review and meta-analysis based on animal studies.Bioactive materials · 2022Article
- Animal models for study on rotator cuff injury.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2021Article
- Basic Research on Tendon Repair: Strategies, Evaluation, and Development.Frontiers in medicine · 2021Review
- Mesenchymal stem cells and their application to rotator cuff pathology: A meta-analysis of pre-clinical studies.Osteoarthritis and cartilage open · 2020Article
- Evaluation of hollow mesh augmentation on the biomechanical properties of the flexor tendon repaired with modified Kessler technique.Journal of orthopaedic translation · 2020Article
- Tendon and Ligament Healing and Current Approaches to Tendon and Ligament Regeneration.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Review
- Cell Therapy-a Basic Science Primer for the Sports Medicine Clinician.Current reviews in musculoskeletal medicine · 2019Review
- In situ tissue engineering of the tendon-to-bone interface by endogenous stem/progenitor cells.Biofabrication · 2019Article
- Biomaterials for the Treatment of Tendon Injury.Tissue engineering and regenerative medicine · 2019Review
- Lateral slit delivery of bone marrow stromal cells enhances regeneration in the decellularized allograft flexor tendon.Journal of orthopaedic translation · 2019Article
- Use of stem cells and growth factors in rotator cuff tendon repair.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2019Review
- Biologics and stem cell-based therapies for rotator cuff repair.Annals of the New York Academy of Sciences · 2019Review
- Enhancement of rotator cuff tendon-bone healing using bone marrow-stimulating technique along with hyaluronic acid.Journal of orthopaedic translation · 2019Article
- CTGF induces tenogenic differentiation and proliferation of adipose-derived stromal cells.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Article
- Current trends in tendinopathy: consensus of the ESSKA basic science committee. Part II: treatment options.Journal of experimental orthopaedics · 2018Review
- New transgenic NIS reporter rats for longitudinal tracking of fibrogenesis by high-resolution imaging.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
hypothesisA composite of multilayer tendon slices (COMTS) seeded with bone marrow stromal cells (BMSCs) may impart mechanical and biologic augmentation effects on supraspinatus tendon repair under tension, thereby improving the healing process after surgery in rats.
methodsAdult female Lewis rats (n = 39) underwent transection of the supraspinatus tendon and a 2-mm tendon resection at the distal end, followed by immediate repair to its bony insertion site under tension. Animals received 1 of 3 treatments at the repair site: (1) no augmentation, (2) COMTS augmentation alone, or (3) BMSC-seeded COMTS augmentation. BMSCs were labeled with a fluorescent cell marker. Animals were euthanized 6 weeks after surgery, and the extent of healing of the repaired supraspinatus tendon was evaluated with biomechanical testing and histologic analysis.
resultsHistologic analysis showed gap formation between the repaired tendon and bone in all specimens, regardless of treatment. Robust fibrous tissue was observed in rats with BMSC-seeded COMTS augmentation; however, fibrous tissue was scarce within the gap in rats with no augmentation or COMTS-only augmentation. Labeled transplanted BMSCs were observed throughout the repair site. Biomechanical analysis showed that the repairs augmented with BMSC-seeded COMTS had significantly greater ultimate load to failure and stiffness compared with other treatments. However, baseline (time 0) data showed that COMTS-only augmentation did not increase mechanical strength of the repair site.
conclusionAlthough the COMTS scaffold did not increase the initial repair strength, the BMSC-seeded scaffold increased healing strength and stiffness 6 weeks after rotator cuff repair in a rat model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.