ArticleScientific reports2015
Dormant phages of Helicobacter pylori reveal distinct populations in Europe.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 52 citations in OpenAlex.
- Helicobacter pylori phages: resource landscape, translational challenges, and engineered antibacterial strategies.Archives of microbiology · 2026Review
- GrafGen: distance-based inference of population ancestry for Helicobacter pylori genomes.BMC bioinformatics · 2025Article
- Investigation of new Helicobacter pylori variants among cagA positive strains using MLST typing method in Iraq.Scientific reports · 2025Article
- Prophage dynamics in gastric and enterohepatic environments: unraveling ecological barriers and adaptive transitions.ISME communications · 2025Article
- Methylome evolution suggests lineage-dependent selection in the gastric pathogen Helicobacter pylori.Communications biology · 2023Article
- Liposomal Delivery of Newly Identified Prophage Lysins in aInternational journal of molecular sciences · 2022Article
- Characterization and Genomic Analysis of a New Phage InfectingInternational journal of molecular sciences · 2022Article
- Cryptic Prophages Contribution forMicroorganisms · 2022Article
- Review
- Genetic diversity and spatial distribution of Burkholderia mallei by core genome-based multilocus sequence typing analysis.PloS one · 2022Article
- Helicobacter pylori infection causes both protective and deleterious effects in human health and disease.Genes and immunity · 2021Review
- Draft Genome Sequences of 29 Helicobacter pylori Strains Isolated from Colombia.Microbiology resource announcements · 2021Article
- Bacteriophages ofFrontiers in microbiology · 2020Review
- Helicobacter pylori recrudescence and its influencing factors.Journal of cellular and molecular medicine · 2019Review
- Comparative study between Helicobacter pylori and host human genetics in the Dominican Republic.BMC evolutionary biology · 2019Article
- Analysis of genetic recombination and the pan-genome of a highly recombinogenic bacteriophage species.Microbial genomics · 2019Article
- Tipping the Scale Toward Gastric Disease: A Host-Pathogen Genomic Mismatch?Current genetic medicine reports · 2018Article
- Relating Phage Genomes toInternational journal of molecular sciences · 2018Review
- Genetic populations and virulence factors of Helicobacter pylori.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2018Review
- [Research progress on genotyping ofZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2018Review
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Authors and funding
8 authors at 8 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prophages of Helicobacter pylori, a bacterium known to co-evolve in the stomach of its human host, were recently identified. However, their role in the diversity of H. pylori strains is unknown. We demonstrate here and for the first time that the diversity of the prophage genes offers the ability to distinguish between European populations, and that H. pylori prophages and their host bacteria share a complex evolutionary history. By comparing the phylogenetic trees of two prophage genes (integrase and holin) and the multilocus sequence typing (MLST)-based data obtained for seven housekeeping genes, we observed that the majority of the strains belong to the same phylogeographic group in both trees. Furthermore, we found that the Bayesian analysis of the population structure of the prophage genes identified two H. pylori European populations, hpNEurope and hpSWEurope, while the MLST sequences identified one European population, hpEurope. The population structure analysis of H. pylori prophages was even more discriminative than the traditional MLST-based method for the European population. Prophages are new players to be considered not only to show the diversity of H. pylori strains but also to more sharply define human populations.
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Registered trials
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