Evidence map›Paper›PMID 26387122›Full record

SynthesisKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2016

Short-term outcomes of platelet-rich plasma injection for treatment of osteoarthritis of the knee.

Wichan Kanchanatawan, Alisara Arirachakaran, Kornkit Chaijenkij, Niti Prasathaporn, Manusak Boonard, Peerapong Piyapittayanun, Jatupon Kongtharvonskul

Registry-linked trialAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07662512 (Is Intra-articular Injection of High-concentration Ozone), which is not on this map. Cited by 43 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 6 pooled it
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07662512 nacompletednot on this mapstarted 2023, after this paper: background citation

Is Intra-articular Injection of High-concentration Ozone (O2-O3) More Effective in Treating Knee Osteoarthritis?: A Multicenter Clinical Trial

TypeinterventionalSponsorSakarya UniversityRan2023 to 2024Enrolled159ConditionsKnee Osteoarthristis, GonarthrosisArmsozone injection
3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 6 syntheses or guidelines pooled it, 123 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Trial
  10. Choice of intra-articular injection in treatment of knee osteoarthritis: platelet-rich plasma, hyaluronic acid or ozone options.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2017
    Trial
  11. Article
  12. Spin and reporting bias in the use of platelet-rich plasma for the treatment of knee osteoarthritis.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Wichan KanchanatawanOrthopedics Department, Lerdsin General Hospital, Bangkok, Thailand.
Alisara ArirachakaranOrthopedics Department, Police General Hospital, Bangkok, Thailand.
Kornkit ChaijenkijOrthopedics Department, College of Sports Science and Technology, Mahidol University, Bangkok, Thailand.
Niti PrasathapornOrthopedics Department, Queen Savang Vadhana Memorial Hospital, Bangkok, Thailand.
Manusak BoonardOrthopedics Department, Srinakarin Hospital, Khonkaen, Thailand.
Peerapong PiyapittayanunOrthopedics Department, Police General Hospital, Bangkok, Thailand.
Jatupon KongtharvonskulSection for Clinical Epidemiology and Biostatistics, Faculty of Medicine, Ramathibodi Hospital, Rama VI Road, Rachatevi, Bangkok, 10400, Thailand. Jatupon_kong@hotmail.com.ORCID http://orcid.org/0000-0001-5871-0898
Police General Hospital · THLerdsin Hospital · THMahidol University · THQueen Saovabha Memorial Institute · THRamathibodi Hospital · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare the clinical outcomes of osteoarthritis indices (WOMAC and Lequesne scores) and adverse events in the treatment of osteoarthritis (OA) of the knee with platelet-rich plasma (PRP) versus hyaluronic acid (HA) or placebo.

methodsA systematic review and meta-regression were performed to compare outcomes between PRP injections versus HA or placebo. Relevant randomized control trials were identified from Medline and Scopus from date of inception to 13 August 2015.

resultsNine of 551 studies were eligible; 6, 5, 5, 5, 2, 2, 2 and 7 studies were included in pooling of WOMAC total, pain, stiffness and function scores, Lequesne score, IKDC score, EQ-VAS score and adverse events in OA knee patients, respectively. The PRP injections had -15.4 (95 % CI -28.6, -2.3, p = 0.021), lower mean WOMAC total scores, and 8.83 (95 % CI 5.88, 11.78, p < 0.001), 7.37 (95 % CI 4.33, 10.05, p = 0.021) higher mean IKDC and EQ-VAS scores when compared to HA injections. However, PRP injections had no significant differences in WOMAC pain, stiffness and function scores, as well as Lequesne score and adverse events when compared to HA or placebo.

conclusionIn short-term outcomes (≤1 year), PRP injection has improved functional outcomes (WOMAC total scores, IKDC score and EQ-VAS) when compared to HA and placebo, but has no statistically significant difference in adverse events when compared to HA and placebo. This study suggests that PRP injection is more efficacious than HA injection and placebo in reducing symptoms and improving function and quality of life. It has the potential to be the treatment of choice in patients with mild-to-moderate OA of the knee who have not responded to conventional treatment. LEVEL OF EVIDENCE: I.

Indexed as

Platelet-Rich PlasmaHumansHyaluronic AcidInjections, Intra-ArticularOsteoarthritis, KneeViscosupplementsHyaluronic AcidViscosupplementsHAHyaluronic acidMeta-analysisOsteoarthritisPlatelet-rich plasmaPRP

Identifiers

PMID26387122
OpenAlexW1728787893

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.