Evidence map›Paper›PMID 26386826›Full record

ArticleDrug and alcohol dependence2015

Mortality among heroin users and users of other internationally regulated drugs: A 27-year follow-up of users in the Epidemiologic Catchment Area Program household samples.

Catalina Lopez-Quintero, Kimberly B Roth, William W Eaton, Li-Tzy Wu, Linda B Cottler, Martha Bruce, James C Anthony

Open access · greenAbstract read
In one paragraph

Article in Drug and alcohol dependence, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 28 citations in OpenAlex.

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  7. Approaching Retention within the ABCD Study.Developmental cognitive neuroscience · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Catalina Lopez-QuinteroDepartment of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, West Fee Hall, 909 Fee Road, East Lansing, MI 48824-1030, United States. Electronic address: clopez@msu.edu.
Kimberly B RothDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Room 880B, 624 North Broadway, Baltimore, MD 21205, United States. Electronic address: kroth@jhsph.edu.
William W EatonDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Room 880B, 624 North Broadway, Baltimore, MD 21205, United States. Electronic address: weaton@jhsph.edu.
Li-Tzy WuDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Duke University Medical Center, Durham, NC 27710, United States. Electronic address: litzy.wu@duke.edu.
Linda B CottlerDepartment of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, 2004 Mowry Road. PO Box 100231, Gainesville, FL 32611, United States. Electronic address: lbcottler@ufl.edu.
Martha BruceDepartment of Psychiatry, Westchester Division, Weill Medical College of Cornell University, White Plains, NY 10605, United States. Electronic address: mbruce@med.cornell.edu.
James C AnthonyDepartment of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, West Fee Hall, 909 Fee Road, East Lansing, MI 48824-1030, United States. Electronic address: janthony@msu.edu.
Johns Hopkins University · USMichigan State University · USCornell University · USDuke University · USUniversity of Florida · US

Funding

Training Program in Drug Dependence EpidemiologyT32DA021129 · NIDA · MICHIGAN STATE UNIVERSITY · PI ANTHONY, JAMES CHRISTOPHER · 2006 to 2016
$2.7M
Evolution of Psychopathology in the PopulationR01DA026652 · NIDA · JOHNS HOPKINS UNIVERSITY · PI EATON, WILLIAM W · 2009 to 2013
$2.4M
Drug Dependence Epidemiology and EnviromicsK05DA015799 · NIDA · MICHIGAN STATE UNIVERSITY · PI ANTHONY, JAMES CHRISTOPHER · 2003 to 2015
$1.4M
NIDA NIH HHS K05 DA015799NIDA NIH HHS K05DA015799NIDA NIH HHS R01 DA026652NIDA NIH HHS R01DA026652NIDA NIH HHS T32 DA021129NIDA NIH HHS T32DA021129
6 · The paper itself

Abstract

backgroundIn contrast to research on more restricted samples of drug users, epidemiological studies open up a view of death rates and survivorship of those who have tried heroin a few times, with no acceleration toward sustained use patterns often seen in treatment and criminal justice samples. At their best, epidemiological estimates of heroin effects on risk of dying are not subject to serious selection biases faced with more restricted samples.

methodsData are from 7207 adult participants aged 18-48 years in United States Epidemiologic Catchment Area Program field surveys, launched in 1980-1984. US National Death Index (NDI) records through 2007 disclosed 723 deaths. NDI enabled estimation of heroin-associated risk of dying as well as survivorship.

resultsEstimated cumulative mortality for all 18-48 year old participants is 3.9 deaths per 1000 person-years (95% confidence interval, CI=3.7, 4.2), relative to 12.4 deaths per 1000 person-years for heroin users (95% CI=8.7, 17.9). Heroin use, even when non-sustained, predicted a 3-4 fold excess of risk of dying prematurely. Post-estimation record review showed trauma and infections as top-ranked causes of these deaths.

conclusionsDrawing strengths from epidemiological sampling, standardized baseline heroin history assessments, and very long-term NDI follow-up, this study of community-dwelling heroin users may help clinicians and public health officials who need facts about heroin when they seek to prevent and control heroin outbreaks. Heroin use, even when sporadic or non-sustained, is predictive of premature death in the US, with expected causes of death such as trauma and infections.

Indexed as

Mortality, PrematureAdolescentAdultDrug UsersFemaleFollow-Up StudiesHeroinHeroin DependenceHumansLogistic ModelsMaleMiddle AgedPublic HealthRiskSubstance-Related DisordersSurvival RateHeroinDeathDrugsDrug useHeroinMortalityOpioidsSurvivorship

Identifiers

PMID26386826
PMCPMC4787597
OpenAlexW1915449400

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.