Evidence map›Paper›PMID 26386637›Full record

ArticleClinical biomechanics (Bristol, Avon)2015

Optimal internal fixation of anatomically shaped synthetic bone grafts for massive segmental defects of long bones.

George C Vorys, Hanying Bai, Chandhanarat Chandhanayingyong, Chang H Lee, Jocelyn T Compton, Jon-Michael Caldwell, Thomas R Gardner, Jeremy J Mao, Francis Y Lee

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical biomechanics (Bristol, Avon), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

George C VorysRobert E. Carroll, MD and Jane Chace Carroll Laboratories for Orthopedic Surgery, Department of Orthopedic Surgery, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Hanying BaiRobert E. Carroll, MD and Jane Chace Carroll Laboratories for Orthopedic Surgery, Department of Orthopedic Surgery, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Chandhanarat ChandhanayingyongRobert E. Carroll, MD and Jane Chace Carroll Laboratories for Orthopedic Surgery, Department of Orthopedic Surgery, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Chang H LeeCenter for Craniofacial Regeneration, School of Dental Medicine, Columbia University, New York, NY, USA.
Jocelyn T ComptonRobert E. Carroll, MD and Jane Chace Carroll Laboratories for Orthopedic Surgery, Department of Orthopedic Surgery, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Jon-Michael CaldwellRobert E. Carroll, MD and Jane Chace Carroll Laboratories for Orthopedic Surgery, Department of Orthopedic Surgery, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Thomas R GardnerRobert E. Carroll, MD and Jane Chace Carroll Laboratories for Orthopedic Surgery, Department of Orthopedic Surgery, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Jeremy J MaoCenter for Craniofacial Regeneration, School of Dental Medicine, Columbia University, New York, NY, USA.
Francis Y LeeRobert E. Carroll, MD and Jane Chace Carroll Laboratories for Orthopedic Surgery, Department of Orthopedic Surgery, College of Physicians and Surgeons, Columbia University, New York, NY, USA. Electronic address: fl127@columbia.edu.
Columbia University · US

Funding

Meniscus Regeneration by Endogenous Stem/Progenitor CellsR01AR065023 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FORTIER, LISA A, LEE, CHANG HUN · 2014 to 2018
$4.6M
Tracking stem cells in engineered tissue and organs in vivo and in real timeR01EB009663 · NIBIB · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAO, JEREMY J · 2009 to 2012
$2.2M
NIAMS NIH HHS AR065023NIAMS NIH HHS R01 AR065023NIBIB NIH HHS EB009663NIBIB NIH HHS R01 EB009663
6 · The paper itself

Abstract

backgroundLarge segmental bone defects following tumor resection, high-energy civilian trauma, and military blast injuries present significant clinical challenges. Tissue engineering strategies using scaffolds are being considered as a treatment, but there is little research into optimal fixation of such scaffolds.

methodsTwelve fresh-frozen paired cadaveric legs were utilized to simulate a critical sized intercalary defect in the tibia. Poly-ε-caprolactone and hydroxyapatite composite scaffolds 5 cm in length with a geometry representative of the mid-diaphysis of an adult human tibia were fabricated, inserted into a tibial mid-diaphyseal intercalary defect, and fixed with a 14-hole large fragment plate. Optimal screw fixation comparing non-locking and locking screws was tested in axial compression, bending, and torsion in a non-destructive manner. A cyclic torsional test to failure under torque control was then performed.

findingsBiomechanical testing showed no significant difference for bending or axial stiffness with non-locking vs. locking fixation. Torsional stiffness was significantly higher (P=0.002) with the scaffold present for both non-locking and locking compared to the scaffold absent. In testing to failure, angular rotation was greater for the non-locking compared to locking constructs at each torque level up to 40 N-m (P<0.05). The locking constructs survived a significantly higher number of loading cycles before reaching clinical failure at 30 degrees of angular rotation (P<0.02).

interpretationThe presence of the scaffold increased the torsional stiffness of the construct. Locking fixation resulted in a stronger construct with increased cycles to failure compared to non-locking fixation.

Indexed as

Bone PlatesBone ScrewsBone TransplantationAgedBiomechanical PhenomenaBone SubstitutesCadaverDurapatiteFemaleFracture Fixation, InternalHumansMalePolyestersStress, MechanicalTibiaTissue EngineeringBone SubstitutesDurapatitepolycaprolactonePolyestersMechanical testingRigid fixationScaffoldsSegmental bone defectsTissue engineering

Identifiers

PMID26386637
PMCPMC9004608
OpenAlexW1768308872

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.