Evidence map›Paper›PMID 26386110›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2015

Aging alters muscle reflex control of autonomic cardiovascular responses to rhythmic contractions in humans.

Simranjit K Sidhu, Joshua C Weavil, Massimo Venturelli, Matthew J Rossman, Benjamin S Gmelch, Amber D Bledsoe, Russell S Richardson, Markus Amann

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02209610 (Premature Fatigue in Veterans With Heart Failure), which is not on this map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02209610 early_phase1completednot on this map

Premature Fatigue in Veterans With Heart Failure: Neuronal Influences

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2015 to 2017Enrolled32ConditionsHeart FailureArmsElectrical and Magnetic Nerve Stimulators, Intrathecal Fentanyl
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 34 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Review
  6. Autonomic cardiovascular control during exercise.American journal of physiology. Heart and circulatory physiology · 2023
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Impact of age on the development of fatigue during large and small muscle mass exercise.American journal of physiology. Regulatory, integrative and comparative physiology · 2018
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Simranjit K SidhuDepartments of Internal Medicine and Discipline of Physiology, School of Medicine, The University of Adelaide, Australia; and simran.sidhu@adelaide.edu.au.
Joshua C WeavilExercise and Sport Science, University of Utah.
Massimo VenturelliDepartments of Internal Medicine and Department of Biomedical Sciences for Health, University of Milan, Italy.
Matthew J RossmanExercise and Sport Science, University of Utah.
Benjamin S GmelchDepartment of Anesthesiology, University of Utah, Salt Lake City, Utah;
Amber D BledsoeDepartment of Anesthesiology, University of Utah, Salt Lake City, Utah;
Russell S RichardsonDepartments of Internal Medicine and Exercise and Sport Science, University of Utah, Geriatric Research Education and Clinical Centers, Veterans Affairs Medical Center, and.
Markus AmannDepartments of Internal Medicine and Exercise and Sport Science, University of Utah, Geriatric Research Education and Clinical Centers, Veterans Affairs Medical Center, and Department of Anesthesiology, University of Utah, Salt Lake City, Utah;
University of Utah · USGeriatric Research Education and Clinical Center · USUniversity of Adelaide · AUUniversity of Milan · IT

Funding

Tissue Imaging, Biochemistry and MorphologyP01HL091830 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HOGAN, MICHAEL C · 2009 to 2013
$10.1M
Role of Sensory Neurons in Human Cardiovascular DiseaseR01HL116579 · NHLBI · UNIVERSITY OF UTAH · PI AMANN, MARKUS · 2013 to 2021
$3.4M
Work of Breathing and Oxidative Stress in COPD: Impact on Blood Flow and FatigueR00HL103786 · NHLBI · UNIVERSITY OF UTAH · PI AMANN, MARKUS · 2013 to 2015
$738k
Respiratory muscle work and oxidative stress in COPD: impact on leg blood flow anK99HL103786 · NHLBI · UNIVERSITY OF UTAH · PI AMANN, MARKUS · 2010 to 2011
$161k
Premature fatigue in veterans with heart failure: neuronal influencesI21RX001572 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI AMANN, MARKUS · 2015 to 2016
–
NHLBI NIH HHS HL-091830NHLBI NIH HHS HL-103786NHLBI NIH HHS HL-116579NHLBI NIH HHS R00 HL103786NHLBI NIH HHS R01 HL116579RRD VA I21 RX001572
6 · The paper itself

Abstract

We investigated the influence of aging on the group III/IV muscle afferents in the exercise pressor reflex-mediated cardiovascular response to rhythmic exercise. Nine old (OLD; 68 ± 2 yr) and nine young (YNG; 24 ± 2 yr) males performed single-leg knee extensor exercise (15 W, 30 W, 80% max) under control conditions and with lumbar intrathecal fentanyl impairing feedback from group III/IV leg muscle afferents. Mean arterial pressure (MAP), cardiac output, leg blood flow (QL), systemic (SVC) and leg vascular conductance (LVC) were continuously determined. With no hemodynamic effect at rest, fentanyl blockade during exercise attenuated both cardiac output and QL ∼17% in YNG, while the decrease in cardiac output in OLD (∼5%) was significantly smaller with no impact on QL (P = 0.8). Therefore, in the face of similar significant ∼7% reduction in MAP during exercise with fentanyl blockade in both groups, LVC significantly increased ∼11% in OLD, but decreased ∼8% in YNG. The opposing direction of change was reflected in SVC with a significant ∼5% increase in OLD and a ∼12% decrease in YNG. Thus while cardiac output seems to account for the majority of group III/IV-mediated MAP responses in YNG, the impact of neural feedback on the heart may decrease with age and alterations in SVC become more prominent in mediating the similar exercise pressor reflex in OLD. Interestingly, in terms of peripheral hemodynamics, while group III/IV-mediated feedback plays a clear role in increasing LVC during exercise in the YNG, these afferents seem to actually reduce LVC in OLD. These peripheral findings may help explain the limited exercise-induced peripheral vasodilation often associated with aging.

Indexed as

Cardiovascular Physiological PhenomenaAdultAgedAgingAnalgesics, OpioidArterial PressureAutonomic Nervous SystemCardiac OutputCardiovascular SystemFemoral ArteryFentanylHumansLegMaleMuscle ContractionMuscle, SkeletalAnalgesics, OpioidFentanylafferent feedbackdynamic exerciseexercise pressor reflex

Identifiers

PMID26386110
PMCPMC4666976
OpenAlexW2175276511

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.