ArticleApplied and environmental microbiology2015
Global transcriptome and mutagenic analyses of the acid tolerance response of Salmonella enterica serovar Typhimurium.
Article in Applied and environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
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- Genotypic and phenotypic analysis ofFrontiers in microbiology · 2024Article
- Exploring Peracetic Acid and Acidic pH Tolerance of Antibiotic-Resistant Non-TyphoidalMicroorganisms · 2023Article
- Activity of a Bacteriophage Cocktail to ControlPHAGE (New Rochelle, N.Y.) · 2023Article
- Effects of colonization-associated gene yqiC on global transcriptome, cellular respiration, and oxidative stress in Salmonella Typhimurium.Journal of biomedical science · 2022Article
- Stress Response Mechanisms ofFoods (Basel, Switzerland) · 2022Article
- Metal sequestration by S100 proteins in chemically diverse environments.Trends in microbiology · 2022Review
- Global transcriptomic analysis of ethanol tolerance response inCurrent research in food science · 2022Article
- Proteomic Analysis of the Antibacterial Effect of Improved Dian Dao San againstEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Downregulation of a novel flagellar synthesis regulator AsiR promotes intracellular replication and systemic pathogenicity ofVirulence · 2021Article
- Vibrio parahaemolyticus CadC regulates acid tolerance response to enhance bacterial motility and cytotoxicity.Journal of fish diseases · 2021Article
- Beyond Homeostasis: Potassium and Pathogenesis during Bacterial Infections.Infection and immunity · 2021Review
- Article
- Impact of the Resistance Responses to Stress Conditions Encountered in Food and Food Processing Environments on the Virulence and Growth Fitness of Non-TyphoidalFoods (Basel, Switzerland) · 2021Review
- A ROD9 island encoded gene in Salmonella Enteritidis plays an important role in acid tolerance response and helps in systemic infection in mice.Virulence · 2020Article
- Transcriptome changes and polymyxin resistance of acid-adapted Escherichia coli O157:H7 ATCC 43889.Gut pathogens · 2020Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salmonella enterica serovar Typhimurium (S. Typhimurium) is one of the leading causative agents of food-borne bacterial gastroenteritis. Swift invasion through the intestinal tract and successful establishment in systemic organs are associated with the adaptability of S. Typhimurium to different stress environments. Low-pH stress serves as one of the first lines of defense in mammalian hosts, which S. Typhimurium must efficiently overcome to establish an infection. Therefore, a better understanding of the molecular mechanisms underlying the adaptability of S. Typhimurium to acid stress is highly relevant. In this study, we have performed a transcriptome analysis of S. Typhimurium under the acid tolerance response (ATR) and found a large number of genes (∼47%) to be differentially expressed (more than 1.5-fold or less than -1.5-fold; P < 0.01). Functional annotation revealed differentially expressed genes to be associated with regulation, metabolism, transport and binding, pathogenesis, and motility. Additionally, our knockout analysis of a subset of differentially regulated genes facilitated the identification of proteins that contribute to S. Typhimurium ATR and virulence. Mutants lacking genes encoding the K(+) binding and transport protein KdpA, hypothetical protein YciG, the flagellar hook cap protein FlgD, and the nitrate reductase subunit NarZ were significantly deficient in their ATRs and displayed varied in vitro virulence characteristics. This study offers greater insight into the transcriptome changes of S. Typhimurium under the ATR and provides a framework for further research on the subject.
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