ArticleGenetics2015
The Genomic Impacts of Drift and Selection for Hybrid Performance in Maize.
Article in Genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Twenty-one years of three-way hybrid breeding shaped diversity and complementarity of male and female gene pools in sugar beet.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Genomic constraint and hypervariability correlate with fitness effects in elite tetraploid potato breeding material.PLoS genetics · 2026Article
- Predicting maize hybrid performance with machine learning and a locus-specific weighted degree of dominance transformation.Frontiers in plant science · 2026Article
- Phenotypic plasticity in maize grain yield: Genetic and environmental insights of response to environmental gradients.The plant genome · 2025Article
- Evolution of population structure in a commercial European hybrid dent maize breeding program and consequences on genetic diversity.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Optimization of recurrent rapid cycle breeding in maize for sustained long-term genetic improvement via stochastic simulations.G3 (Bethesda, Md.) · 2025Article
- Portability of genomic predictions trained on sparse factorial designs across two maize silage breeding cycles.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Breeding for improved digestibility and processing of lignocellulosic biomass inFrontiers in plant science · 2024Review
- Improving hybrid rice breeding programs via stochastic simulations: number of parents, number of hybrids, tester update, and genomic prediction of hybrid performance.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- A genomic analysis of the University of Nebraska Replicated Recurrent Selection program.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Identifying QTLs involved in hybrid performance and heterotic group complementarity: new GWAS models applied to factorial and admixed diallel maize hybrid panels.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Maximization through optimization? On the relationship between hybrid performance and parental genetic distance.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Review
- Molecular characterization of doubled haploid lines derived from different cycles of the Iowa Stiff Stalk Synthetic (BSSS) maize population.Frontiers in plant science · 2023Article
- Genomic prediction for the Germplasm Enhancement of Maize project.The plant genome · 2022Article
- Genome properties of key oil palm (Elaeis guineensis Jacq.) breeding populations.Journal of applied genetics · 2022Article
- Genomic insights into historical improvement of heterotic groups during modern hybrid maize breeding.Nature plants · 2022Article
- Article
- Genomic variation within the maize stiff-stalk heterotic germplasm pool.The plant genome · 2021Article
- Characterization of heterosis and genomic prediction-based establishment of heterotic patterns for developing better hybrids in pigeonpea.The plant genome · 2021Article
- Dominance Effects and Functional Enrichments Improve Prediction of Agronomic Traits in Hybrid Maize.Genetics · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although maize is naturally an outcrossing organism, modern breeding utilizes highly inbred lines in controlled crosses to produce hybrids. The U.S. Department of Agriculture's reciprocal recurrent selection experiment between the Iowa Stiff Stalk Synthetic (BSSS) and the Iowa Corn Borer Synthetic No. 1 (BSCB1) populations represents one of the longest running experiments to understand the response to selection for hybrid performance. To investigate the genomic impact of this selection program, we genotyped the progenitor lines and >600 individuals across multiple cycles of selection using a genome-wide panel of ∼40,000 SNPs. We confirmed previous results showing a steady temporal decrease in genetic diversity within populations and a corresponding increase in differentiation between populations. Thanks to detailed historical information on experimental design, we were able to perform extensive simulations using founder haplotypes to replicate the experiment in the absence of selection. These simulations demonstrate that while most of the observed reduction in genetic diversity can be attributed to genetic drift, heterozygosity in each population has fallen more than expected. We then took advantage of our high-density genotype data to identify extensive regions of haplotype fixation and trace haplotype ancestry to single founder inbred lines. The vast majority of regions showing such evidence of selection differ between the two populations, providing evidence for the dominance model of heterosis. We discuss how this pattern is likely to occur during selection for hybrid performance and how it poses challenges for dissecting the impacts of modern breeding and selection on the maize genome.
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