ArticleProceedings of the National Academy of Sciences of the United States of America2015
Birth of a new gene on the Y chromosome of Drosophila melanogaster.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Strong bias in long-read sequencing prevents assembly ofGenome research · 2026Article
- Male sterility in Drosophila mojavensis × D. arizonae hybrids is not caused by gene movements in the Y chromosome.Evolution; international journal of organic evolution · 2025Article
- Co-transcriptional splicing facilitates transcription of gigantic genes.PLoS genetics · 2024Article
- Cis-regulatory polymorphism at fiz ecdysone oxidase contributes to polygenic evolutionary response to malnutrition in Drosophila.PLoS genetics · 2024Article
- Sex-linked gene traffic underlies the acquisition of sexually dimorphic UV color vision inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Gene-poor Y-chromosomes substantially impact male trait heritabilities and may help shape sexually dimorphic evolution.Heredity · 2023Article
- Expressed genes and their new alleles identification during fibre elongation reveal the genetic factors underlying improvements of fibre length in cotton.Plant biotechnology journal · 2022Article
- Review
- Novel patterns of expression and recruitment of new genes on theProceedings. Biological sciences · 2022Article
- Article
- New Genes in theGenes · 2021Article
- Extreme Y chromosome polymorphism corresponds to five male reproductive morphs of a freshwater fish.Nature ecology & evolution · 2021Article
- piRNA-mediated gene regulation and adaptation to sex-specific transposon expression inGenes & development · 2021Article
- Evolution of genome structure in theGenome research · 2021Article
- Article
- Transcribed sex-specific markers on the Y chromosome of the oriental fruit fly, Bactrocera dorsalis.BMC genetics · 2020Article
- Sequence Transpositions Restore Genes on the Highly Degenerated W Chromosomes of Songbirds.Genes · 2020Article
- The Y Chromosome as a Battleground for Intragenomic Conflict.Trends in genetics : TIG · 2020Review
- The Role of Y Chromosome Genes in Male Fertility inGenetics · 2020Article
- Evolution of a New Function by Fusion between Phage DNA and a Bacterial Gene.Molecular biology and evolution · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
Abstract
Contrary to the pattern seen in mammalian sex chromosomes, where most Y-linked genes have X-linked homologs, the Drosophila X and Y chromosomes appear to be unrelated. Most of the Y-linked genes have autosomal paralogs, so autosome-to-Y transposition must be the main source of Drosophila Y-linked genes. Here we show how these genes were acquired. We found a previously unidentified gene (flagrante delicto Y, FDY) that originated from a recent duplication of the autosomal gene vig2 to the Y chromosome of Drosophila melanogaster. Four contiguous genes were duplicated along with vig2, but they became pseudogenes through the accumulation of deletions and transposable element insertions, whereas FDY remained functional, acquired testis-specific expression, and now accounts for ∼20% of the vig2-like mRNA in testis. FDY is absent in the closest relatives of D. melanogaster, and DNA sequence divergence indicates that the duplication to the Y chromosome occurred ∼2 million years ago. Thus, FDY provides a snapshot of the early stages of the establishment of a Y-linked gene and demonstrates how the Drosophila Y has been accumulating autosomal genes.
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