Trial reportEuropean radiology2016
Increased tumour ADC value during chemotherapy predicts improved survival in unresectable pancreatic cancer.
Trial report in European radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Summary from the 2025 International Society for Magnetic Resonance in Medicine workshop on body MRI: Unsolved problems and unmet needs.Magnetic resonance in medicine · 2026Review
- Synthetic data generation method improves risk prediction model for early tumor recurrence after surgery in patients with pancreatic cancer.Scientific reports · 2025Article
- Toward diffusion MRI in the diagnosis and treatment of pancreatic cancer.Medical oncology (Northwood, London, England) · 2025Review
- Direct correlation of MR-DWI and histopathology of Wilms' tumours through a patient-specific 3D-printed cutting guide.European radiology · 2025Article
- Precision of liver and pancreas apparent diffusion coefficients using motion-compensated gradient waveforms in DWI.Magnetic resonance imaging · 2024Article
- Value of diffusion kurtosis MR imaging and conventional diffusion weighed imaging for evaluating response to first-line chemotherapy in unresectable pancreatic cancer.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Article
- Interval changes of histogram-derived diffusion indices predict treatment response to induction chemotherapy in head and neck cancer: a feasibility study.Quantitative imaging in medicine and surgery · 2022Article
- Role of apparent diffusion coefficient measurement in differentiating histological subtypes of brain metastasis of lung cancer.Revista da Associacao Medica Brasileira (1992) · 2022Article
- Article
- Apparent diffusion coefficients (ADC) in response assessment of transarterial radioembolization (TARE) for liver metastases of neuroendocrine tumors (NET): a feasibility study.Acta radiologica (Stockholm, Sweden : 1987) · 2022Article
- Characterization and correction of cardiovascular motion artifacts in diffusion-weighted imaging of the pancreas.Magnetic resonance in medicine · 2021Article
- Diffusion-Weighted and Dynamic Contrast-Enhanced MRI Derived Imaging Metrics for Stereotactic Body Radiotherapy of Pancreatic Ductal Adenocarcinoma: Preliminary Findings.Tomography (Ann Arbor, Mich.) · 2020Article
- Dinaciclib prolongs survival in theAmerican journal of translational research · 2020Article
- Dendritic cell immunotherapy induces anti-tumor effect in a transgenic mouse model of pancreatic ductal adenocarcinoma.American journal of cancer research · 2019Article
- Radiomics Facilitates Candidate Selection for Irradiation Stents Among Patients With Unresectable Pancreatic Cancer.Frontiers in oncology · 2019Article
- Scan time reduction in diffusion-weighted imaging of the pancreas using a simultaneous multislice technique with different acceleration factors: How fast can we go?European radiology · 2018Article
- Curative effect of minimally invasive surgery on palmar and foot hyperhidrosis and its influence on serum-related cytokines and immunoglobulins.Experimental and therapeutic medicine · 2018Article
- Correlation of ADC With Pathological Treatment Response for Radiation Therapy of Pancreatic Cancer.Translational oncology · 2018Article
- Apparent Diffusion Coefficient (ADC) predicts therapy response in pancreatic ductal adenocarcinoma.Scientific reports · 2017Article
- Prognostic value of pretreatment diffusion-weighted magnetic resonance imaging for outcome prediction of colorectal cancer liver metastases undergoing 90Y-microsphere radioembolization.Journal of cancer research and clinical oncology · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate whether changes to the apparent diffusion coefficient (ADC) of primary tumour in the early period after starting chemotherapy can predict progression-free survival (PFS) or overall survival (OS) in patients with unresectable pancreatic adenocarcinoma.
methodsSubjects comprised 43 patients with histologically confirmed unresectable pancreatic cancer treated with first-line chemotherapy. Minimum ADC values in primary tumour were measured using the selected area ADC (sADC), which excluded cystic and necrotic areas and vessels, and the whole tumour ADC (wADC), which included whole tumour components. Relative changes in ADC were calculated from baseline to 4 weeks after initiation of chemotherapy. Relationships between ADC and both PFS and OS were modelled by Cox proportional hazards regression.
resultsMedian PFS and OS were 6.1 and 11.0 months, respectively. In multivariate analysis, sADC change was the strongest predictor of PFS (hazard ratio (HR), 4.5; 95 % confidence interval (CI), 1.7-11.9; p = 0.002). Multivariate Cox regression analysis for OS revealed sADC change and CRP as independent predictive markers, with sADC change as the strongest predictive biomarker (HR, 6.7; 95 % CI, 2.7-16.6; p = 0.001).
conclusionRelative changes in sADC could provide a useful imaging biomarker to predict PFS and OS with chemotherapy for unresectable pancreatic adenocarcinoma. KEY POINTS: • Relative change in ADC value can predict survival in unresectable pancreatic cancer. • ADC change could determine a chemosensitivity of pancreatic cancer. • ADC values should be measured by excluding cystic, necrotic areas and vessels.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.