ArticleSocial cognitive and affective neuroscience2016
Genetic and neural correlates of romantic relationship satisfaction.
Article in Social cognitive and affective neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Does losing money truly hurt? The shared neural bases of monetary loss and pain.Human brain mapping · 2022Pooled it
- Social exclusion reliably engages the default network: A meta-analysis of Cyberball.NeuroImage · 2021Pooled it
- Bifidobacterium longum 1714™ Strain Modulates Brain Activity of Healthy Volunteers During Social Stress.The American journal of gastroenterology · 2019Trial
- Genetic contributions to the stability and satisfaction in Sexual Relationships.Global medical genetics · 2025Review
- Neural Mechanisms Underlying the Impact of Psychological Resilience on Psychosocial Stress Responses.Depression and anxiety · 2024Article
- Genetic and epigenetic effects on couple adjustment in context of romantic relationship: A scoping systematic review.Frontiers in genetics · 2023Article
- A Genetic Variation in the Y Chromosome Among Modern Japanese Males Related to Several Physiological and Psychological Characteristics.Frontiers in behavioral neuroscience · 2021Article
- The MAOA Gene Influences the Neural Response to Psychosocial Stress in the Human Brain.Frontiers in behavioral neuroscience · 2020Article
- 5-HTTLPR moderates the association between interdependence and brain responses to mortality threats.Human brain mapping · 2017Article
- The oxytocinergic system modulates sadistic context-dependent empathy in humans.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Romantic relationship satisfaction (RRS) is important for mental/physical health but varies greatly across individuals. To date, we have known little about the biological (genetic and neural) correlates of RRS. We tested the hypothesis that the serotonin transporter promoter polymorphism (5-HTTLPR), the promoter region of the gene SLC6A4 that codes for the serotonin transporter protein, is associated with individuals' RRS. Moreover, we investigated neural activity that mediates 5-HTTLPR association with RRS by scanning short-short (s/s) and long-long (l/l) homozygotes of 5-HTTLPR, using functional MRI, during a Cyberball game that resulted in social exclusion. l/l compared with s/s allele carriers reported higher RRS but lower social interaction anxiety. l/l compared with s/s carriers showed stronger activity in the right ventral prefrontal cortex (RVPFC) and stronger functional connectivity between the dorsal and rostral ACC when being excluded from the Cyberball game. Moreover, the 5-HTTLPR association with RRS was mediated by the RVPFC activity and the 5-HTTLPR association with social interaction anxiety was mediated by both the dorsal-rostral ACC connectivity and RVPFC activity. Our findings suggest that 5-HTTLPR is associated with satisfaction of one's own romantic relationships and this association is mediated by the neural activity in the brain region related to emotion regulation.
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