ArticleBMC complementary and alternative medicine2015
Nigella sativa fixed and essential oil modulates glutathione redox enzymes in potassium bromate induced oxidative stress.
Article in BMC complementary and alternative medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Effect ofTheScientificWorldJournal · 2020Pooled it
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- Antioxidant and Anti-Inflammatory Effects of Bioactive Compounds in Atherosclerosis.International journal of molecular sciences · 2025Review
- Nutrient utilization, growth performance, and antioxidative status of Barki lambs fed diets supplemented with black (Nigella sativa) and rocket (Eruca sativa) seeds.Tropical animal health and production · 2024Article
- Physicochemical, Rheological and Sensory Evaluation of Herbal Bread Containing Turmeric, Ginger, and Black Cumin Powder.Foods (Basel, Switzerland) · 2024Article
- Comprehensive and updated review on anti-oxidant effects ofIranian journal of basic medical sciences · 2024Review
- In vitro study of Nigella sativa and thymoquinone activity on endothelial activation and monocyte adhesion.Journal of applied biomedicine · 2023Article
- Review
- Protective Effects of Black Cumin (International journal of molecular sciences · 2021Review
- The effect of dietary supplementation with Nigella sativa (black seeds) mediates immunological function in male Wistar rats.Scientific reports · 2021Article
- Revisiting pharmacological potentials of Nigella sativa seed: A promising option for COVID-19 prevention and cure.Phytotherapy research : PTR · 2021Review
- Nigella Sativa's Anti-Inflammatory and Antioxidative Effects in Experimental Inflammation.Antioxidants (Basel, Switzerland) · 2020Article
- Review
- Article
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNigella sativa is an important component of several traditional herbal preparations in various countries. It finds its applications in improving overall health and boosting immunity. The current study evaluated the role of fixed and essential oil of Nigella sativa against potassium bromate induced oxidative stress with special reference to modulation of glutathione redox enzymes and myeloperoxidase.
methodsAnimals; 30 rats (Sprague Dawley) were divided in three groups and oxidative stress was induced using mild dose of potassium bromate. The groups were on their respective diets (iso-caloric diets for a period of 56 days) i.e. control and two experimental diets containing N. sativa fixed (4%) and essential (0.3%) oils. The activities of enzymes involved in glutathione redox system and myeloperoxidase (MPO) were analyzed.
resultsThe experimental diets modulated the activities of enzymes i.e. glutathione-S-transferase (GST), glutathione reductase (GR) and glutathione peroxidase (GPx) positively. Indices of antioxidant status like tocopherols and glutathione were in linear relationship with that of GPx, GR and GST (P<0.01). MPO activities were in negative correlation with GST (P<0.01) but positive correlation with some other parameters.
conclusionsOur results indicated that both Nigella sativa fixed and essential oil are effective in improving the antioxidant indices against potassium bromate induced oxidative stress.
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