Evidence map›Paper›PMID 26385493›Full record

ArticleComparative immunology, microbiology and infectious diseases2015

Phenotypic and functional analysis of CD1a+ dendritic cells from cats chronically infected with feline immunodeficiency virus.

Lin Zhang, Stacie Reckling, Gregg A Dean

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Comparative immunology, microbiology and infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Lin ZhangDepartment of Microbiology, Immunology and Pathology, College of Veterinary Medicine, Colorado State University, Fort Collins, CO 80523, USA.
Stacie RecklingDepartment of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA.
Gregg A DeanDepartment of Microbiology, Immunology and Pathology, College of Veterinary Medicine, Colorado State University, Fort Collins, CO 80523, USA. Electronic address: gregg.dean@colostate.edu.
Colorado State University · USNorth Carolina State University · US

Funding

BASIS AND MODULATION OF THE INNATE IMMUNE DEFECT IN FIVR01AI047707 · NIAID · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI DEAN, GREGG A · 2001 to 2010
$2.5M
NIAID NIH HHS R01 AI047707PHS HHS R01-A1047707
6 · The paper itself

Abstract

Numerous studies suggest dendritic cell (DC) dysfunction is central to the dysregulated immune response during HIV infection; however, in vivo studies are lacking. In the present study we used feline immunodeficiency virus (FIV) infection of cats as a model for HIV-1 infection to assess the maturation and function of dendritic cells, in vivo and in vitro. We compared CD1a+ DC migration, surface phenotype, endocytosis, mixed leukocyte reaction (MLR) and regulatory T cell (Treg) phenotype induction by CD1a+ cells isolated from lymph nodes of FIV-infected and control cats. Results showed that resident CD1a+ DC in lymph nodes of chronically FIV-infected cats are phenotypically mature, can stimulate normal primary T cell proliferation, override Treg suppression and do not skew toward Treg induction. In contrast, FIV infection had deleterious effects on antigen presentation and migratory capacity of CD1a+ cells in tissues.

Indexed as

AnimalsAntigen PresentationAntigens, CD1CatsCell MovementChronic DiseaseDendritic CellsDisease Models, AnimalFeline Acquired Immunodeficiency SyndromeHIV InfectionsImmunodeficiency Virus, FelineLymph NodesLymphocyte ActivationLymphocyte Culture Test, MixedPhenotypeT-Lymphocytes, RegulatoryAntigens, CD1CD1a antigenCD1aDendritic cellsFeline immunodeficiency virusRegulatory T cells

Identifiers

PMID26385493
PMCPMC10252145
OpenAlexW2207792776

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.