Evidence map›Paper›PMID 26385451›Full record

ReviewHeart (British Cardiac Society)2015

Post-resuscitation care following out-of-hospital and in-hospital cardiac arrest.

Saket Girotra, Paul S Chan, Steven M Bradley

Registry-linked trialAbstract readReview
In one paragraph

Review in Heart (British Cardiac Society), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03539497 (Prognostic Value of Plasma Mitochondrial DNA and Cytochrome C After Cardiac Arrest), which is not on this map. Cited by 57 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03539497 unknown statusnot on this mapstarted 2019, after this paper: background citation

Prognostic Value of Plasma Mitochondrial DNA and Cytochrome C After Cardiac Arrest

TypeobservationalSponsorUniversity Medical Centre LjubljanaRan2019 to 2024Enrolled87ConditionsCardiac ArrestArmsBiomarker
3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  12. Evolution of brain injury and neurological dysfunction after cardiac arrest in the rat - A multimodal and comprehensive model.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Saket GirotraDepartment of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Paul S ChanSaint Luke's Mid America Heart Institute and the University of Missouri-Kansas City, VA Eastern Colorado Health Care System, Denver, Colorado, USA.
Steven M BradleyUniversity of Colorado School of Medicine at the Anschutz Medical Campus, Aurora, Colorado, USA.

Funding

Hospital Enhancement of Resuscitation Outcomes for In-Hospital Cardiac Arrest (HER01HL123980 · NHLBI · SAINT LUKE'S HOSPITAL · PI CHAN, PAUL SHEUNG-YAN, NALLAMOTHU, BRAHMAJEE K · 2014 to 2018
$2.7M
Post-Resuscitation Care and Survival After In-hospital Cardiac ArrestK08HL122527 · NHLBI · UNIVERSITY OF IOWA · PI GIROTRA, SAKET · 2014 to 2018
$731k
The Appropriateness Criteria for Coronary Revascularization: Feasibility of MeasuK23HL102224 · NHLBI · SAINT LUKE'S HOSPITAL · PI CHAN, PAUL SHEUNG-YAN · 2010 to 2014
$610k
HSRD VA CDA 10-199NHLBI NIH HHS 1R01HL123980NHLBI NIH HHS K08 HL122527NHLBI NIH HHS K08HL122 527NHLBI NIH HHS K23 HL102224NHLBI NIH HHS K23HL102224NHLBI NIH HHS R01 HL123980
6 · The paper itself

Abstract

Cardiac arrest is a leading cause of death in developed countries. Although a majority of cardiac arrest patients die during the acute event, a substantial proportion of cardiac arrest deaths occur in patients following successful resuscitation and can be attributed to the development of post-cardiac arrest syndrome. There is growing recognition that integrated post-resuscitation care, which encompasses targeted temperature management (TTM), early coronary angiography and comprehensive critical care, can improve patient outcomes. TTM has been shown to improve survival and neurological outcome in patients who remain comatose especially following out-of-hospital cardiac arrest due to ventricular arrhythmias. Early coronary angiography and revascularisation if needed may also be beneficial during the post-resuscitation phase, based on data from observational studies. In addition, resuscitated patients usually require intensive care, which includes mechanical ventilator, haemodynamic support and close monitoring of blood gases, glucose, electrolytes, seizures and other disease-specific intervention. Efforts should be taken to avoid premature withdrawal of life-supporting treatment, especially in patients treated with TTM. Given that resources and personnel needed to provide high-quality post-resuscitation care may not exist at all hospitals, professional societies have recommended regionalisation of post-resuscitation care in specialised 'cardiac arrest centres' as a strategy to improve cardiac arrest outcomes. Finally, evidence for post-resuscitation care following in-hospital cardiac arrest is largely extrapolated from studies in patients with out-of-hospital cardiac arrest. Future studies need to examine the effectiveness of different post-resuscitation strategies, such as TTM, in patients with in-hospital cardiac arrest.

Indexed as

Cardiopulmonary ResuscitationCoronary AngiographyHospitalizationHypothermia, InducedPercutaneous Coronary InterventionCentralized Hospital ServicesCombined Modality TherapyDelivery of Health Care, IntegratedEarly DiagnosisHeart ArrestHumansModels, OrganizationalOut-of-Hospital Cardiac ArrestPredictive Value of TestsQuality of Health CareRisk Factors

Identifiers

PMID26385451
PMCPMC4780335

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.