Evidence map›Paper›PMID 26385424›Full record

ReviewCurrent opinion in virology2015

Recent advances on viral manipulation of NF-κB signaling pathway.

Jun Zhao, Shanping He, Arlet Minassian, Junhua Li, Pinghui Feng

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 91 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jun ZhaoDepartment of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, United States.
Shanping HeDepartment of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, United States.
Arlet MinassianDepartment of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, United States.
Junhua LiDepartment of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, United States.
Pinghui FengDepartment of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, United States. Electronic address: pinghui.feng@med.usc.edu.
University of Southern California · US

Funding

Roles of the K3 and K5 in KSHV Persistence and PathogenesisP01CA180779 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JUNG, JAE U · 2013 to 2017
$7.3M
Proviral Roles of an Innate Immune PathwayR01DE021445 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FENG, PINGHUI · 2011 to 2017
$2.5M
Post-Translational Events Underlying the KSHV vGPCR PathogenesisR01CA134241 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI FENG, PINGHUI · 2009 to 2013
$1.6M
A recombinant virus approach for gamma herpesvirus oncogenesisR21AI105340 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FENG, PINGHUI · 2014 to 2015
$452k
NCI NIH HHS CA134241NCI NIH HHS P01 CA180779NCI NIH HHS R01 CA134241NIAID NIH HHS R21 AI105340NIDCR NIH HHS DE021445NIDCR NIH HHS R01 DE021445
6 · The paper itself

Abstract

NF-κB transcription factors regulate the expression of hundreds of genes primarily involved in immune responses. Signaling events leading to NF-κB activation constitute a major antiviral immune pathway. To replicate and persist within their hosts, viruses have evolved diverse strategies to evade and exploit cellular NF-κB immune signaling cascades for their benefit. We summarize recent studies concerning viral manipulation of the NF-κB signaling pathway downstream of pattern recognition receptors. Signal transduction mediated by pattern recognition receptors is a research frontier for both infectious disease and innate immunology.

Indexed as

Host-Pathogen InteractionsHumansImmunity, InnateNF-kappa BReceptors, Pattern RecognitionSignal TransductionViral Envelope ProteinsViral ProteinsVirusesNF-kappa BReceptors, Pattern RecognitionViral Envelope ProteinsViral Proteins

Identifiers

PMID26385424
PMCPMC4688235
OpenAlexW1652794785

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.