Evidence map›Paper›PMID 26385402›Full record

Trial reportFertility and sterility2015

Cross-sectional study of factors influencing sex hormone-binding globulin concentrations in normally cycling premenopausal women.

Talia N Crawford, Andrea Y Arikawa, Mindy S Kurzer, Kathryn H Schmitz, William R Phipps

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Fertility and sterility, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00393172 (Women in Steady Exercise Research), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00393172 phase2 / phase3completednot on this map

Women in Steady Exercise Research (WISER)

TypeinterventionalSponsorUniversity of MinnesotaRan2006 to 2010Enrolled400ConditionsBreast Cancer, ObesityArmsexercise
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Talia N CrawfordDepartment of Obstetrics, Gynecology, and Women's Health, University of Minnesota, Minneapolis, Minnesota.
Andrea Y ArikawaDepartment of Food Science and Nutrition, University of Minnesota, St. Paul, Minnesota.
Mindy S KurzerDepartment of Food Science and Nutrition, University of Minnesota, St. Paul, Minnesota.
Kathryn H SchmitzDepartment of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania.
William R PhippsDepartment of Obstetrics, Gynecology, and Women's Health, University of Minnesota, Minneapolis, Minnesota. Electronic address: wphippsmd@rrc.com.
University of Minnesota · USUniversity of Pennsylvania · US

Funding

YOUTH DRUG ABUSE, ADHD, AND RELATED DISRUPTIVE DISORDERSM01RR000400 · NCRR · UNIVERSITY OF MINNESOTA TWIN CITIES · PI KOTLYAR, MICHAEL · 1985 to 2009
$33.7M
WOmen-Oxidative Stress, Estrogens, and Exercise (WOOSEE)U54CA116849 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI JEFFERY, ROBERT W · 2005 to 2010
$10.8M
NCI NIH HHS 1U54CA116849-010003NCRR NIH HHS M01 RR000400NCRR NIH HHS M01-RR00400
6 · The paper itself

Abstract

objectiveTo assess the relationship between SHBG and 18 other hormonal and metabolic parameters in well characterized, normally cycling premenopausal women.

designCross-sectional study.

settingUniversity general clinical research center. SUBJECT(S): A total of 319 young healthy women with ovulatory menstrual cycles. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Midfollicular serum SHBG concentrations. RESULT(S): In our final linear regression model, SHBG was negatively associated with bioavailable T and positively associated with adiponectin, associations that were independent from other parameters. SHBG was also positively associated with estrone sulfate, but only when taking into account confounding variables. Unexpectedly, there was no straightforward relationship between SHBG and insulin resistance according to homeostasis-model assessment. CONCLUSION(S): Our results highlight the link between androgen action, as reflected by bioavailable T, and circulating SHBG concentrations in all premenopausal women and speak to the importance of the relationship between SHBG and adiponectin, which is at least in part independent from androgen action. CLINICAL TRIAL REGISTRATION NUMBER: NCT00393172.

Indexed as

AdiponectinAdultBiomarkersCross-Sectional StudiesEstroneFemaleFollicular PhaseHumansLinear ModelsMultivariate AnalysisPremenopauseSex Hormone-Binding GlobulinTestosteroneYoung AdultAdiponectinADIPOQ protein, humanBiomarkersEstroneestrone sulfateSex Hormone-Binding GlobulinTestosteroneadiponectininsulin resistancepremenopauseSex hormone–binding globulintestosterone

Identifiers

PMID26385402
PMCPMC4663171
OpenAlexW1642503781

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.