Evidence map›Paper›PMID 26385375›Full record

ArticleJournal of biomedical informatics2015

Comparison of machine learning classifiers for influenza detection from emergency department free-text reports.

Arturo López Pineda, Ye Ye, Shyam Visweswaran, Gregory F Cooper, Michael M Wagner, Fuchiang Rich Tsui

Abstract readComparative Study
In one paragraph

Article in Journal of biomedical informatics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Article
  2. Review
  3. Artificial Intelligence in Emergency Medicine: A Primer for the Nonexpert.Journal of the American College of Emergency Physicians open · 2025
    Article
  4. Online Transfer Learning for RSV Case Detection.Proceedings. IEEE International Conference on Healthcare Informatics · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Modern Machine-Learning Predictive Models for Diagnosing Infectious Diseases.Computational and mathematical methods in medicine · 2022
    Review
  11. Detection and Prevention of Virus Infection.Advances in experimental medicine and biology · 2022
    Article
  12. Advances in the Rapid Diagnostic of Viral Respiratory Tract Infections.Frontiers in cellular and infection microbiology · 2022
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Arturo López PinedaDepartment of Biomedical Informatics, University of Pittsburgh School of Medicine, 5607 Baum Boulevard, Pittsburgh, PA, United States.
Ye YeDepartment of Biomedical Informatics, University of Pittsburgh School of Medicine, 5607 Baum Boulevard, Pittsburgh, PA, United States; Intelligent System Program, University of Pittsburgh Dietrich School of Arts and Sciences, 210 South Bouquet Street, Pittsburgh, PA, United States.
Shyam VisweswaranDepartment of Biomedical Informatics, University of Pittsburgh School of Medicine, 5607 Baum Boulevard, Pittsburgh, PA, United States; Intelligent System Program, University of Pittsburgh Dietrich School of Arts and Sciences, 210 South Bouquet Street, Pittsburgh, PA, United States.
Gregory F CooperDepartment of Biomedical Informatics, University of Pittsburgh School of Medicine, 5607 Baum Boulevard, Pittsburgh, PA, United States; Intelligent System Program, University of Pittsburgh Dietrich School of Arts and Sciences, 210 South Bouquet Street, Pittsburgh, PA, United States.
Michael M WagnerDepartment of Biomedical Informatics, University of Pittsburgh School of Medicine, 5607 Baum Boulevard, Pittsburgh, PA, United States; Intelligent System Program, University of Pittsburgh Dietrich School of Arts and Sciences, 210 South Bouquet Street, Pittsburgh, PA, United States.
Fuchiang Rich TsuiDepartment of Biomedical Informatics, University of Pittsburgh School of Medicine, 5607 Baum Boulevard, Pittsburgh, PA, United States; Intelligent System Program, University of Pittsburgh Dietrich School of Arts and Sciences, 210 South Bouquet Street, Pittsburgh, PA, United States. Electronic address: tsui2@pitt.edu.

Funding

Development and Evaluation of a Learning Electronic Medical Record SystemR01LM012095 · NLM · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VISWESWARAN, SHYAM · 2015 to 2018
$1.8M
Probabilistic Disease SurveillanceR01LM011370 · NLM · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WAGNER, MICHAEL MATTHEW · 2013 to 2015
$1.7M
Predicting Patient Outcomes from Clinical and Genome-Wide DataR01LM010020 · NLM · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COOPER, GREGORY F. · 2009 to 2010
$1.2M
NLM NIH HHS R01 LM010020NLM NIH HHS R01LM010020NLM NIH HHS R01 LM011370NLM NIH HHS R01LM011370NLM NIH HHS R01 LM012095NLM NIH HHS R01LM012095PHITPO CDC HHS P01 HK000086PHITPO CDC HHS P01HK000086PHITPO CDC HHS U38 HK000063PHITPO CDC HHS U38HK000063
6 · The paper itself

Abstract

Influenza is a yearly recurrent disease that has the potential to become a pandemic. An effective biosurveillance system is required for early detection of the disease. In our previous studies, we have shown that electronic Emergency Department (ED) free-text reports can be of value to improve influenza detection in real time. This paper studies seven machine learning (ML) classifiers for influenza detection, compares their diagnostic capabilities against an expert-built influenza Bayesian classifier, and evaluates different ways of handling missing clinical information from the free-text reports. We identified 31,268 ED reports from 4 hospitals between 2008 and 2011 to form two different datasets: training (468 cases, 29,004 controls), and test (176 cases and 1620 controls). We employed Topaz, a natural language processing (NLP) tool, to extract influenza-related findings and to encode them into one of three values: Acute, Non-acute, and Missing. Results show that all ML classifiers had areas under ROCs (AUC) ranging from 0.88 to 0.93, and performed significantly better than the expert-built Bayesian model. Missing clinical information marked as a value of missing (not missing at random) had a consistently improved performance among 3 (out of 4) ML classifiers when it was compared with the configuration of not assigning a value of missing (missing completely at random). The case/control ratios did not affect the classification performance given the large number of training cases. Our study demonstrates ED reports in conjunction with the use of ML and NLP with the handling of missing value information have a great potential for the detection of infectious diseases.

Indexed as

Emergency Service, HospitalMachine LearningHumansInfluenza, HumanBayesianCase detectionEmergency department reportsInfluenzaMachine learning

Identifiers

PMID26385375
PMCPMC4684714

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.