ArticleClinical immunology (Orlando, Fla.)2015
Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus.
Abstract read
In one paragraph
Article in Clinical immunology (Orlando, Fla.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Association of leptin gene polymorphisms (rs791620 and rs7799039) with rheumatoid arthritis susceptibility and clinical manifestations: a case-control study.Clinical rheumatology · 2026Article
- Review
- Role of serum leptin levels and leptin receptor gene polymorphisms in systemic lupus erythematosus.Clinical rheumatology · 2020Article
- Association ofBioMed research international · 2020Article
- The Impact of Vitamin D on Cognitive Dysfunction in Mice with Systemic Lupus Erythematosus.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Symptoms of systemic lupus erythematosus are diagnosed in leptin transgenic pigs.PLoS biology · 2018Article
- Association of leptin and leptin receptor gene polymorphisms with systemic lupus erythematosus in a Chinese population.Journal of cellular and molecular medicine · 2017Article
- Leptin promotes systemic lupus erythematosus by increasing autoantibody production and inhibiting immune regulation.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
39 authors.
Jian ZhaoDepartment of Medicine, University of California Los Angeles, Los Angeles, CA, United States.
Hui WuDepartment of Medicine, University of California Los Angeles, Los Angeles, CA, United States.
Carl D LangefeldDepartment of Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, NC, United States.
Kenneth M KaufmanCincinnati Children's Hospital Medical Center, Cincinnati, OH, United States; US Department of Veterans Affairs Medical Center, Cincinnati, OH, United States.
Jennifer A KellyArthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.
Sang-Cheol BaeDepartment of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea.
Marta E. Alarcón-Riquelme for the BIOLUPUS and GENLES networks
Graciela S AlarcónDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Juan-Manuel AnayaCenter for Autoimmune Diseases Research, Universidad del Rosario, Bogotá, Colombia.
Lindsey A CriswellRosalind Russell/Ephraim P. Engleman Rheumatology Research Center, University of California San Francisco, San Francisco, CA, United States.
Barry I FreedmanDepartment of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United States.
Diane L KamenMedical University of South Carolina, Charleston, SC, United States.
Gary S GilkesonMedical University of South Carolina, Charleston, SC, United States.
Chaim O JacobDepartment of Medicine, University of Southern California, Los Angeles, CA, United States.
Judith A JamesArthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States; Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States; Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Joan T MerrillClinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.
Patrick M GaffneyArthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.
Kathy Moser SivilsArthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States; Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Timothy B NiewoldDepartment of Immunology, Mayo Clinic, Rochester, MN, United States.
Michelle A PetriDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Seung Taek SongDepartment of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea.
Hye-Jin JeongDepartment of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea.
Rosalind Ramsey-GoldmanNorthwestern University Feinberg School of Medicine, Chicago, IL, United States.
John D ReveilleRheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston, Houston, TX, United States.
R Hal ScofieldArthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States; Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States; US Department of Veterans Affairs Medical Center, Oklahoma City, OK, United States.
Anne M StevensDepartment of Pediatrics, University of Washington, Seattle, WA, United States; Center for Immunity and Immunotherapies, Seattle Children's Research Institute Seattle, WA, United States.
Susan A BoackleUniversity of Colorado School of Medicine, Aurora, CO, United States; US Department of Veterans Affairs Medical Center, Denver, CO, United States.
Luis M ViláDepartment of Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico.
Deh-Ming ChangNational Defense Medical Center, Taipei City, Taiwan.
Yeong Wook SongSeoul National University, Seoul, South Korea.
Timothy J VyseKing's College London, London, UK.
John B HarleyCincinnati Children's Hospital Medical Center, Cincinnati, OH, United States; US Department of Veterans Affairs Medical Center, Cincinnati, OH, United States.
Elizabeth E BrownDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, United States.
Jeffrey C EdbergDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Robert P KimberlyDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Bevra H HahnDepartment of Medicine, University of California Los Angeles, Los Angeles, CA, United States.
Jennifer M GrossmanDepartment of Medicine, University of California Los Angeles, Los Angeles, CA, United States.
Betty P TsaoDepartment of Medicine, University of California Los Angeles, Los Angeles, CA, United States. Electronic address: btsao@mednet.ucla.edu.
Antonio La CavaDepartment of Medicine, University of California Los Angeles, Los Angeles, CA, United States. Electronic address: alacava@mednet.ucla.edu.
Funding
Transform Dissemination and Implementation Science in CTSA ProgramsUL1TR002319 · NCATS · UNIVERSITY OF WASHINGTON · PI John K. Amory · 2017 to 2026
$100.0MEngaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0MTracking and Evaluation CoreU54GM104938 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI PAUL G SPICER · 2013 to 2026
$68.2MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MNorthwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8MINSTITUTE FOR TRANSLATIONAL HEALTH SCIENCE (UL1): BPCAUL1RR025014 · NCRR · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2007 to 2011
$51.5MColorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0MLCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI MEINZEN-DERR, JAREEN, STRAWN, JEFFREY ROBERT · 2015 to 2024
$37.5MUAB Center for Clinical and Translational Science (CCTS)UL1TR001417 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2015 to 2018
$31.4MTRANSLATIONAL RESEARCH UNIVERSITY OF CHICAGO: CLINICAL TRIALSUL1RR024999 · NCRR · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2007 to 2011
$25.3MVALIDATING NOVEL GENES IMPLICATED IN LEUKOCYTE CHEMOTAXISP20RR020143 · NCRR · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI GAFFNEY, PATRICK M · 2004 to 2011
$21.0MRe-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2MArthritis Research UKNCATS NIH HHS TR000004NCATS NIH HHS TR000124NCATS NIH HHS TR001417NCATS NIH HHS TR001422NCATS NIH HHS UL1 TR000004NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR000430NCATS NIH HHS UL1 TR001082NCATS NIH HHS UL1 TR001417NCATS NIH HHS UL1 TR001422NCATS NIH HHS UL1 TR001425NCATS NIH HHS UL1 TR002319NCI NIH HHS CA141700NCI NIH HHS R01 CA141700NCRR NIH HHS P20 RR020143NCRR NIH HHS RR020143NCRR NIH HHS RR023417NCRR NIH HHS RR024999NCRR NIH HHS RR025014NCRR NIH HHS RR029882NCRR NIH HHS RR033176NCRR NIH HHS UL1 RR024999NCRR NIH HHS UL1 RR025014NCRR NIH HHS UL1 RR029882NCRR NIH HHS UL1 RR033176NIAID NIH HHS AI024717NIAID NIH HHS AI063274NIAID NIH HHS AI070304NIAID NIH HHS AI071651NIAID NIH HHS AI082714NIAID NIH HHS AI083194NIAID NIH HHS AI083790NIAID NIH HHS AI101934NIAID NIH HHS K08 AI083790NIAID NIH HHS K24 AI078004NIAID NIH HHS L30 AI071651NIAID NIH HHS P01 AI083194NIAID NIH HHS R01 AI024717NIAID NIH HHS R01 AI063274NIAID NIH HHS R21 AI070304NIAID NIH HHS R37 AI024717NIAID NIH HHS R56 AI063274NIAID NIH HHS U01 AI101934NIAID NIH HHS U19 AI082714NIAMS NIH HHS AR002138NIAMS NIH HHS AR033062NIAMS NIH HHS AR042460NIAMS NIH HHS AR043274NIAMS NIH HHS AR043814NIAMS NIH HHS AR048311NIAMS NIH HHS AR049084NIAMS NIH HHS AR051545NIAMS NIH HHS AR053308NIAMS NIH HHS AR053483NIAMS NIH HHS AR055385NIAMS NIH HHS AR057172NIAMS NIH HHS AR058621NIAMS NIH HHS AR062755NIAMS NIH HHS AR064820NIAMS NIH HHS AR065626NIAMS NIH HHS AR066464NIAMS NIH HHS AR43727NIAMS NIH HHS AR53239NIAMS NIH HHS K24 AR002138NIAMS NIH HHS N01 AR062277NIAMS NIH HHS P01 AR049084NIAMS NIH HHS P30 AR048311NIAMS NIH HHS P30 AR053483NIAMS NIH HHS P60 AR053308NIAMS NIH HHS P60 AR062755NIAMS NIH HHS R01 AR033062NIAMS NIH HHS R01 AR042460NIAMS NIH HHS R01 AR043274NIAMS NIH HHS R01 AR043727NIAMS NIH HHS R01 AR043814NIAMS NIH HHS R01 AR051545NIAMS NIH HHS R01 AR053239NIAMS NIH HHS R01 AR057172NIAMS NIH HHS R01 AR064820NIAMS NIH HHS R21 AR065626NIAMS NIH HHS RC1 AR058621NIGMS NIH HHS GM103510NIGMS NIH HHS GM104938NIGMS NIH HHS P30 GM103510NIGMS NIH HHS U54 GM104938Wellcome Trust
Abstract
Leptin is abnormally elevated in the plasma of patients with systemic lupus erythematosus (SLE), where it is thought to promote and/or sustain pro-inflammatory responses. Whether this association could reflect an increased genetic susceptibility to develop SLE is not known, and studies of genetic associations with leptin-related polymorphisms in SLE patients have been so far inconclusive. Here we genotyped DNA samples from 15,706 SLE patients and healthy matched controls from four different ancestral groups, to correlate polymorphisms of genes of the leptin pathway to risk for SLE. It was found that although several SNPs showed weak associations, those associations did not remain significant after correction for multiple testing. These data do not support associations between defined leptin-related polymorphisms and increased susceptibility to develop SLE.
Indexed as
Case-Control StudiesGenetic Predisposition to DiseaseGenotypeHumansLeptinLupus Erythematosus, SystemicPolymorphism, Single NucleotideLeptinGene polymorphismsLeptin pathwaySystemic lupus erythematosus
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