Evidence map›Paper›PMID 26385055›Full record

ArticleNeuroscience research2016

DISC1 signaling in cocaine addiction: Towards molecular mechanisms of co-morbidity.

Amy Gancarz, Yan Jouroukhin, Atsushi Saito, Alexey Shevelkin, Lauren E Mueller, Atsushi Kamiya, David M Dietz, Mikhail V Pletnikov

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Amy GancarzThe State University of New York at Buffalo, Buffalo, NY, USA.
Yan JouroukhinDepartment of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, USA.
Atsushi SaitoDepartment of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, USA.
Alexey ShevelkinDepartment of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, USA.
Lauren E MuellerThe State University of New York at Buffalo, Buffalo, NY, USA.
Atsushi KamiyaDepartment of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, USA.
David M DietzThe State University of New York at Buffalo, Buffalo, NY, USA. Electronic address: ddietz@buffalo.edu.
Mikhail V PletnikovDepartment of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, USA; Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, USA; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA. Electronic address: mpletni1@jhu.edu.
Johns Hopkins Medicine · USUniversity at Buffalo, State University of New York · USJohns Hopkins University · US

Funding

RESEARCH TRAINING ON ALCOHOL ETIOLOGY AND TREATMENTT32AA007583 · NIAAA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Gregory G Homish, Jennifer P Read · 2000 to 2026
$8.5M
Mutant DISC 1 and Abnormal Neurodevelopment in Mental IllnessR01MH083728 · NIMH · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI PLETNIKOV, MIKHAIL V · 2009 to 2020
$4.9M
Cocaine-induced neuroplasticity: a new role for TGF beta signalingR01DA037257 · NIDA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI DIETZ, DAVID M · 2014 to 2018
$2.1M
DISC1 Pathway in Dendritogenesis: Implications for Dopamine Circuit and CognitionR01MH091230 · NIMH · JOHNS HOPKINS UNIVERSITY · PI KAMIYA, ATSUSHI · 2010 to 2014
$1.6M
Exploring depressive behavior using a natural product for novel drug targetsR21AT008547 · NCCIH · JOHNS HOPKINS UNIVERSITY · PI KAMIYA, ATSUSHI · 2014 to 2015
$439k
NCCIH NIH HHS R21 AT008547NIAAA NIH HHS T32 AA007583NIDA NIH HHS R01 DA037257NIMH NIH HHS R01 MH083728NIMH NIH HHS R01 MH091230
6 · The paper itself

Abstract

Substance abuse and other psychiatric diseases may share molecular pathology. In order to test this hypothesis, we examined the role of Disrupted In Schizophrenia 1 (DISC1), a psychiatric risk factor, in cocaine self-administration (SA). Cocaine SA significantly increased expression of DISC1 in the nucleus accumbens (NAc); while knockdown of DISC1 in NAc significantly increased cocaine SA and decreased phosphorylation of GSK-3β at Ser9 compared to scrambled shRNA. Our study provides the first mechanistic evidence of a critical role of DISC1 in drug-induced behavioral neuroadaptations and sheds more light at the shared molecular pathology of drug abuse and other major psychiatric disorders.

Indexed as

AnimalsBehavior, AddictiveCocaineCocaine-Related DisordersGlycogen Synthase Kinase 3 betaMaleNerve Tissue ProteinsNucleus AccumbensPhosphorylationRats, Sprague-DawleySelf AdministrationSignal TransductionCocaineDisc1 protein, ratGlycogen Synthase Kinase 3 betaNerve Tissue ProteinsCocaineCo-morbidityDISC1Drug abusePsychiatric disorders

Identifiers

PMID26385055
PMCPMC4792800
OpenAlexW2254627863

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.