Trial reportNeuroscience2017
Early deprivation, atypical brain development, and internalizing symptoms in late childhood.
Trial report in Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Neuroimaging predictors of onset and course of depression in childhood and adolescence: A systematic review of longitudinal studies.Developmental cognitive neuroscience · 2019Pooled it
- Child mental health after institutional care in Azerbaijan: prevalence and correlates.BMC public health · 2026Trial
- Enigma of autism regression mechanistic pathways, clinical phenotypes, and early intervention implications.World journal of clinical pediatrics · 2026Review
- Childhood white matter organization predicts adolescent internalizing problems among youth with and without ADHD.NeuroImage. Clinical · 2026Article
- Post-weaning maternal presence exerts a protective effect against social isolation-induced behavioural alterations in mice.Scientific reports · 2025Article
- Pathways to child mental health: A structural equation model of economic deprivation, parenting, and internalizing problems.SSM. Mental health · 2025Article
- Multivariate Links Between the Developmental Timing of Adversity Exposure and White Matter Tract Connectivity in Adulthood.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Trauma of separation: the social and emotional impact of institutionalization on children in a post-soviet country.BMC public health · 2023Article
- The Bucharest Early Intervention Project: Adolescent mental health and adaptation following early deprivation.Child development perspectives · 2022Article
- The heart of the matter: Developing the whole child through community resources and caregiver relationships.Development and psychopathology · 2021Article
- Animal Behaviour: Learning Social Distancing.Current biology : CB · 2020Article
- Juvenile Social Isolation Enhances the Activity of Inhibitory Neuronal Circuits in the Medial Prefrontal Cortex.Frontiers in cellular neuroscience · 2020Article
- Childhood maltreatment experiences are associated with altered diffusion in occipito-temporal white matter pathways.Brain and behavior · 2020Article
- Pubertal stress recalibration reverses the effects of early life stress in postinstitutionalized children.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The role of the visual association cortex in scaffolding prefrontal cortex development: A novel mechanism linking socioeconomic status and executive function.Developmental cognitive neuroscience · 2019Review
- The Neuroscience of Drug Reward and Addiction.Physiological reviews · 2019Review
- Mechanisms linking childhood adversity with psychopathology: Learning as an intervention target.Behaviour research and therapy · 2019Review
- Translating Developmental Neuroscience to Understand Risk for Psychiatric Disorders.The American journal of psychiatry · 2019Review
- Brain Structural Alterations in Left-Behind Children: A Magnetic Resonance Imaging Study.Frontiers in neural circuits · 2019Article
- Differential Associations of Distinct Forms of Childhood Adversity With Neurobehavioral Measures of Reward Processing: A Developmental Pathway to Depression.Child development · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Children exposed to extreme early-life neglect such as in institutional rearing are at heightened risk for developing depression and anxiety disorders, and internalizing problems more broadly. These outcomes are believed to be due to alterations in the development of neural circuitry that supports emotion regulation. The specific neurodevelopmental changes that contribute to these difficulties are largely unknown. This study examined whether microstructural alterations in white matter pathways predicted long-term risk for internalizing problems in institutionally reared children. Data from 69 children were drawn from the Bucharest Early Intervention Project, a randomized clinical trial of foster care for institutionally reared children. White matter was assessed using diffusion tensor imaging (DTI) when children were between 8 and 10years of age. Internalizing symptoms were assessed at the time of the MRI scan, and once children reached 12-14years of age. Results indicated that neglect-associated alterations in the external capsule and corpus callosum partially explained links between institutional rearing status and internalizing symptoms in middle childhood and early adolescence. Findings shed light on neural mechanisms contributing to increased risk for emotional difficulties among children reared in adverse conditions and have implications for prevention and intervention.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.