ArticleG3 (Bethesda, Md.)2015
RNAseq Analysis Highlights Specific Transcriptome Signatures of Yeast and Mycelial Growth Phases in the Dutch Elm Disease Fungus Ophiostoma novo-ulmi.
Article in G3 (Bethesda, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 27 citations in OpenAlex.
- An Ammonium Transporter Gene Contributes to the Aggressiveness of the Dutch Elm Disease PathogenJournal of fungi (Basel, Switzerland) · 2026Article
- Coordinated gene family evolution shapes the genome of dimorphic Mucorales.Nature communications · 2026Article
- Rapid gain and loss of a chromosome drives key morphology and virulence phenotypes in the fungal pathogen Histoplasma.PLoS biology · 2026Article
- Genomic Exploration of Climate-driven Evolution and Evolutionary Convergence in Forest Pathogens.Genome biology and evolution · 2025Article
- What are the 100 most cited fungal genera?Studies in mycology · 2024Article
- Unraveling the transcriptional features and gene expression networks of pathogenic and saprotrophicMicrobiology spectrum · 2024Article
- Core endophytic mycobiome inFrontiers in plant science · 2023Article
- Independent Evolution Has Led to Distinct Genomic Signatures in Dutch Elm Disease-Causing Fungi and Other Vascular Wilts-Causing Fungal Pathogens.Journal of fungi (Basel, Switzerland) · 2022Article
- Comparative Analysis of Transcriptomes ofJournal of fungi (Basel, Switzerland) · 2022Article
- An Efficient Strategy for Obtaining Mutants by Targeted Gene Deletion inFrontiers in microbiology · 2021Article
- Comparative RNAseq Analysis of the Insect-Pathogenic FungusG3 (Bethesda, Md.) · 2020Article
- Hybridization and introgression drive genome evolution of Dutch elm disease pathogens.Nature ecology & evolution · 2020Article
- CRISPR/Cas9 Gene Editing: An Unexplored Frontier for Forest Pathology.Frontiers in plant science · 2020Review
- Morphological changes in response to environmental stresses in the fungal plant pathogen Zymoseptoria tritici.Scientific reports · 2019Article
- Sporotrichosis: From KOH to Molecular Biology.Journal of fungi (Basel, Switzerland) · 2018Review
- Fungal Dimorphism and Virulence: Molecular Mechanisms for Temperature Adaptation, Immune Evasion, and In Vivo Survival.Mediators of inflammation · 2017Review
- Genome-Wide Analysis of Secondary Metabolite Gene Clusters in OFrontiers in microbiology · 2017Article
- From yeast to hypha: defining transcriptomic signatures of the morphological switch in the dimorphic fungal pathogen Ophiostoma novo-ulmi.BMC genomics · 2016Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Fungal dimorphism is a complex trait and our understanding of the ability of fungi to display different growth morphologies is limited to a small number of model species. Here we study a highly aggressive dimorphic fungus, the ascomycete Ophiostoma novo-ulmi, which is a model in plant pathology and the causal agent of Dutch elm disease. The two growth phases that this fungus displays, i.e., a yeast phase and mycelial phase, are thought to be involved in key steps of disease development. We used RNAseq to investigate the genome-wide gene expression profiles that are associated with yeast and mycelial growth phases in vitro. Our results show a clear molecular distinction between yeast and mycelial phase gene expression profiles. Almost 12% of the gene content is differentially expressed between the two phases, which reveals specific functions related to each growth phase. We compared O. novo-ulmi transcriptome profiles with those of two model dimorphic fungi, Candida albicans and Histoplasma capsulatum. Few orthologs showed similar expression regulation between the two growth phases, which suggests that, globally, the genes associated with these two life forms are poorly conserved. This poor conservation underscores the importance of developing specific tools for emerging model species that are distantly related to the classical ones. Taken together, our results provide insights into transcriptome regulation and molecular specificity in O. novo-ulmi and offer a new perspective for understanding fungal dimorphism.
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