Evidence map›Paper›PMID 26384588›Full record

ReviewBipolar disorders2015

A report on older-age bipolar disorder from the International Society for Bipolar Disorders Task Force.

Martha Sajatovic, Sergio A Strejilevich, Ariel G Gildengers, Annemiek Dols, Rayan K Al Jurdi, Brent P Forester, Lars Vedel Kessing, John Beyer, Facundo Manes, Soham Rej and 5 more

Abstract readReview
In one paragraph

Review in Bipolar disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. Assessing bipolar disorder in the older adult: the GERI-BD toolbox.International journal of geriatric psychiatry · 2018
    Trial
  4. Review
  5. Article
  6. Review
  7. Article
  8. Observational
  9. Article
  10. Brain White Matter Microstructure in Middle and Older Aged Adults With Bipolar Disorder: A 2-Site Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026
    Article
  11. The spectrum of bipolar disorder in older adults.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. The role of predominant polarity in older age bipolar disorder.International journal of bipolar disorders · 2025
    Article
  17. Review
  18. Article
  19. Article
  20. Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Martha SajatovicDepartment of Psychiatry, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, OH, USA.
Sergio A StrejilevichBipolar Disorder Program, Neurosciences Institute, Favaloro University, Buenos Aires, Argentina.
Ariel G GildengersDepartment of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA.
Annemiek DolsDepartment of Old Age Psychiatry, GGZ inGeest, EMGO Institute of Care and Health Research, VU University Medical Center, Amsterdam, the Netherlands.
Rayan K Al JurdiMichael E. DeBakey VA Medical Center, Houston, TX, USA.
Brent P ForesterDivision of Geriatric Psychiatry, McLean Hospital, Harvard Medical School, Boston, MA, USA.
Lars Vedel KessingPsychiatric Centre Copenhagen, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
John BeyerDuke University Medical Center, Durham, NC, USA.
Facundo ManesInstitute of Cognitive Neurology (INECO), Favaloro University, Buenos Aires, Argentina.
Soham RejDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada.
Adriane R RosaFederal University of Rio Grande do Sul, Porto Alegre, Brazil.
Sigfried Ntm SchouwsDepartment of Old Age Psychiatry, GGZ inGeest, EMGO Institute of Care and Health Research, VU University Medical Center, Amsterdam, the Netherlands.
Shang-Ying TsaiDepartment of Psychiatry, Taipei Medical University Hospital, Taipei, Taiwan.
Robert C YoungWeill Cornell Medical College and New York Presbyterian Hospital, White Plains, NY, USA.
Kenneth I ShulmanDepartment of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.

Funding

Treatment of Bipolar Disorder in Old AgeK02MH067028 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI YOUNG, ROBERT C. · 2003 to 2013
$1.2M
NIMH NIH HHS K02 MH067028NIMH NIH HHS KOZ MH0670
6 · The paper itself

Abstract

objectivesIn the coming generation, older adults with bipolar disorder (BD) will increase in absolute numbers as well as proportion of the general population. This is the first report of the International Society for Bipolar Disorder (ISBD) Task Force on Older-Age Bipolar Disorder (OABD).

methodsThis task force report addresses the unique aspects of OABD including epidemiology and clinical features, neuropathology and biomarkers, physical health, cognition, and care approaches.

resultsThe report describes an expert consensus summary on OABD that is intended to advance the care of patients, and shed light on issues of relevance to BD research across the lifespan. Although there is still a dearth of research and health efforts focused on older adults with BD, emerging data have brought some answers, innovative questions, and novel perspectives related to the notion of late onset, medical comorbidity, and the vexing issue of cognitive impairment and decline.

conclusionsImproving our understanding of the biological, clinical, and social underpinnings relevant to OABD is an indispensable step in building a complete map of BD across the lifespan.

Indexed as

Bipolar DisorderCognitionAgedAge of OnsetComorbidityFemaleGeriatric AssessmentHumansMalePsychotropic DrugsPsychotropic Drugsbipolar disordercognitionelderlygeriatricmanic depressive disordermood stabilizers

Identifiers

PMID26384588
PMCPMC4623878

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.