ArticleG3 (Bethesda, Md.)2015
Long-Lasting Gene Conversion Shapes the Convergent Evolution of the Critical Methanogenesis Genes.
Article in G3 (Bethesda, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Crystal structure of methanogen MtxX (Methanogen Marker Protein MMP4) fromFEMS microbes · 2026Article
- The origin and evolution of methanogenesis andPNAS nexus · 2023Article
- Methanogenic archaea use a bacteria-like methyltransferase system to demethoxylate aromatic compounds.The ISME journal · 2021Article
- A methylotrophic origin of methanogenesis and early divergence of anaerobic multicarbon alkane metabolism.Science advances · 2021Article
- Archaeal Connectase is a specific and efficient protein ligase related to proteasome β subunits.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Post-Translational Modifications Aid Archaeal Survival.Biomolecules · 2020Review
- Phylogenomic analysis demonstrates a pattern of rare and long-lasting concerted evolution in prokaryotes.Communications biology · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Methanogenesis and its key small-molecule methyltransferase Mtr complex are poorly understood despite their pivotal role in Earth's global carbon cycle. Mtr complex is encoded by a conserved mtrEDCBAFGH operon in most methanogens. Here we report that two discrete lineages, Methanococcales and Methanomicrobiales, have a noncanonical mtr operon carrying two copies of mtrA resulting from an ancient duplication. Compared to mtrA-1, mtrA-2 acquires a distinct transmembrane domain through domain shuffling and gene fusion. However, the nontransmembrane domains (MtrA domain) of mtrA-1 and mtrA-2 are homogenized by gene conversion events lasting throughout the long history of these extant methanogens (over 2410 million years). Furthermore, we identified a possible recruitment of ancient nonmethanogenic methyltransferase genes to establish the methanogenesis pathway. These results not only provide novel evolutionary insight into the methanogenesis pathway and methyltransferase superfamily but also suggest an unanticipated long-lasting effect of gene conversion on gene evolution in a convergent pattern.
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Registered trials
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