Evidence map›Paper›PMID 26383884›Full record

ArticlePediatric research2016

Prevalence of anemia and associations between neonatal iron status, hepcidin, and maternal iron status among neonates born to pregnant adolescents.

Sunmin Lee, Ronnie Guillet, Elizabeth M Cooper, Mark Westerman, Mark Orlando, Tera Kent, Eva Pressman, Kimberly O O'Brien

Open access · bronzeAbstract read
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In one paragraph

Article in Pediatric research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Common Hematological Reference Indices Among Healthy Reproductive Age Indian Women-Data Subset from Nationwide Study.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Identifying and treating iron deficiency anemia in pregnancy.Hematology. American Society of Hematology. Education Program · 2023
    Article
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  17. Review
  18. Article
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  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Sunmin LeeDivision of Nutritional Sciences, Cornell University, Ithaca, New York.
Ronnie GuilletDepartment of Pediatrics, Neonatology, University of Rochester School of Medicine and Dentistry, Rochester, New York.
Elizabeth M CooperDepartment of Obstetrics and Gynecology, University of Rochester School of Medicine and Dentistry, Rochester, New York.
Mark WestermanIntrinsic Life Sciences LLC, La Jolla, California.
Mark OrlandoDepartment of Otolaryngology, University of Rochester School of Medicine and Dentistry, Rochester, New York.
Tera KentDivision of Nutritional Sciences, Cornell University, Ithaca, New York.
Eva PressmanDepartment of Obstetrics and Gynecology, University of Rochester School of Medicine and Dentistry, Rochester, New York.
Kimberly O O'BrienDivision of Nutritional Sciences, Cornell University, Ithaca, New York.
University of Rochester · USCornell University · USIntrinsic LifeSciences (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLittle is known about anemia and iron status in US newborns because screening for anemia is typically not undertaken until 1 y of age. This study was undertaken to characterize and identify determinants of iron status in newborns born to pregnant adolescents.

methodsPregnant adolescents (≤ 18 y, n = 193) were followed from ≥ 12 wk gestation until delivery. Hemoglobin, ferritin, soluble transferrin receptor, serum iron, hepcidin, erythropoietin (EPO), IL-6, and C-reactive protein were assessed in maternal and cord blood.

resultsAt birth, 21% of the neonates were anemic (Hb < 13.0 g/dl) and 25% had low iron stores (ferritin < 76 µg/l). Cord serum ferritin concentrations were not significantly associated with gestational age (GA) at birth across the range of 37-42 wk. Neonates born to mothers with ferritin < 12 µg/l had significantly lower ferritin (P = 0.003) compared to their counterparts. Hepcidin and IL-6 were significantly (P < 0.05) higher in neonates born to mothers with longer durations of active labor.

conclusionGiven the importance of the iron stores at birth on maintenance of iron homeostasis over early infancy, additional screening of iron status at birth is warranted among those born to this high risk obstetric population.

Indexed as

AdolescentAnemiaBirth WeightBlack or African AmericanC-Reactive ProteinErythropoietinFemaleFerritinsFetal BloodGestational AgeHepcidinsHumansInfant, NewbornInfant, PrematureInfant, Small for Gestational AgeInterleukin-6C-Reactive ProteinEPO protein, humanErythropoietinFerritinsHepcidinsIL6 protein, humanInterleukin-6IronReceptors, Transferrin

Identifiers

PMID26383884
OpenAlexW2407056566

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.